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Q1QVG9 (DDL_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Csal_2188
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341082

Regions

Domain114 – 309196ATP-grasp
Nucleotide binding140 – 19556ATP By similarity

Sites

Metal binding2631Magnesium or manganese 1 By similarity
Metal binding2761Magnesium or manganese 1 By similarity
Metal binding2761Magnesium or manganese 2 By similarity
Metal binding2781Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QVG9 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 9E7535E400633071

FASTA31433,673
        10         20         30         40         50         60 
MSDTVTDGDA SRRRHGRVVV VYGGRSAERE VSLLSGGAVL ASLVRSGVDA HGFDFAGGGL 

        70         80         90        100        110        120 
SGLEALAPDR VFIAMHGRDG EDGSLQGALE LLGIPYTGSG VLASALGMDK ERTKQLWRAH 

       130        140        150        160        170        180 
GLPTPESVML EGEPDWDAVI EALGLPLIVK PVHEGSTIGI SIVETRDALI AAHAEASRFD 

       190        200        210        220        230        240 
SAIMAERFVQ GEEYTVSLLG DEVLPAIRVE VPSGFYDYEA KYHSDTTRYL LPCGLEQEEE 

       250        260        270        280        290        300 
RMLGDVCRRA FEAIGGRGWG RVDVMRDAQG RFWLLEVNTV PGMTDHSLVP QAAAHAGLDF 

       310 
DALVLRILDT TTGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000285 Genomic DNA. Translation: ABE59539.1.
RefSeqYP_574238.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QVG9.
SMRQ1QVG9. Positions 16-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290398.Csal_2188.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE59539; ABE59539; Csal_2188.
GeneID4026682.
KEGGcsa:Csal_2188.
PATRIC21448228. VBIChrSal113723_2208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CHRSD
AccessionPrimary (citable) accession number: Q1QVG9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways