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Q1QV15 (SYL_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Csal_2344
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 856856Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009324

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif615 – 6195"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6181ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QV15 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 37952B02BD302926

FASTA85695,491
        10         20         30         40         50         60 
MDAQYTPHAI ESAAQTFWDK NQCFKAVEDA TREKFYCLSM FPYPSGKLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VVSRFQRMQG KNVLQPMGWD AFGMPAENAA IKNRVPPGAW TYDNIDAMRR QLKALGFAYD 

       130        140        150        160        170        180 
WNREFATCDV DYYRWEQWFF TKLVEKGLVY KKMSTVNWDP VDQTVLANEQ VIEGRGWRSG 

       190        200        210        220        230        240 
ALVERKEIPL WFLKITDYAD ELLADLDKVD WPEQVKTMQR NWIGKSTGVE LSFAVADSSE 

       250        260        270        280        290        300 
QLEVYTTRPD TLYGVTYVAV AAGHPLARQA AQDNPALGDF LEECQQGGNS EAELATMEKK 

       310        320        330        340        350        360 
GMDTGHKAIH PLTGREVPIF VANFVLMEYG TGAVMAVPAH DQRDWEFATK YGIPIEPVIA 

       370        380        390        400        410        420 
DAEGNTPDLS QGAHTEHGKL INSGEFDGLE FDAAFDAIAA RLEANGQGTV KTNFRLRDWG 

       430        440        450        460        470        480 
VARQRYWGAP IPVKYGPEGQ TVPLTDDELP VALPMEVEVD ASGSPLKKMP AFYDLGEGWT 

       490        500        510        520        530        540 
RETDTFDTFM ESSWYYARFA SADNMEAMLD ERADYWLPVD LYIGGIEHAI LHLLYARFFH 

       550        560        570        580        590        600 
KLMRDFGLVA SDEPFQRLLT QGMVIAETFY RANDDGSKDW FNPADVDVQR DDKGRPVSAI 

       610        620        630        640        650        660 
LREDGQPVEM GGIEKMSKSK NNGVDPQAMI DRFGADTVRL FMMFAAPPEQ SLEWSDSGVE 

       670        680        690        700        710        720 
GAHRFLKRLW KLVADHLDAG TPAALDADAL NDDQKTLRRK THETIAKASD DIGRRTTFNT 

       730        740        750        760        770        780 
AIAAVMELVN AIGRFEDTSP QGLAVTREAL EACVLVLAPI VPHACHALWD ALGHDTPVID 

       790        800        810        820        830        840 
AAWPQADEAA MVKDSVELAV QVNGKLRARL DVPAAADKAA IEAQALEAEN VRRHTEGKTI 

       850 
RKVIVVPGKL VNIVAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000285 Genomic DNA. Translation: ABE59693.1.
RefSeqYP_574392.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QV15.
SMRQ1QV15. Positions 228-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290398.Csal_2344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE59693; ABE59693; Csal_2344.
GeneID4026303.
KEGGcsa:Csal_2344.
PATRIC21448538. VBIChrSal113723_2362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_CHRSD
AccessionPrimary (citable) accession number: Q1QV15
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries