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Q1QV15

- SYL_CHRSD

UniProt

Q1QV15 - SYL_CHRSD

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Protein
Leucine--tRNA ligase
Gene
leuS, Csal_2344
Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei618 – 6181ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Csal_2344
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Leucine--tRNA ligaseUniRule annotation
PRO_1000009324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_2344.

Structurei

3D structure databases

ProteinModelPortaliQ1QV15.
SMRiQ1QV15. Positions 228-411.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi615 – 6195"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QV15-1 [UniParc]FASTAAdd to Basket

« Hide

MDAQYTPHAI ESAAQTFWDK NQCFKAVEDA TREKFYCLSM FPYPSGKLHM    50
GHVRNYTIGD VVSRFQRMQG KNVLQPMGWD AFGMPAENAA IKNRVPPGAW 100
TYDNIDAMRR QLKALGFAYD WNREFATCDV DYYRWEQWFF TKLVEKGLVY 150
KKMSTVNWDP VDQTVLANEQ VIEGRGWRSG ALVERKEIPL WFLKITDYAD 200
ELLADLDKVD WPEQVKTMQR NWIGKSTGVE LSFAVADSSE QLEVYTTRPD 250
TLYGVTYVAV AAGHPLARQA AQDNPALGDF LEECQQGGNS EAELATMEKK 300
GMDTGHKAIH PLTGREVPIF VANFVLMEYG TGAVMAVPAH DQRDWEFATK 350
YGIPIEPVIA DAEGNTPDLS QGAHTEHGKL INSGEFDGLE FDAAFDAIAA 400
RLEANGQGTV KTNFRLRDWG VARQRYWGAP IPVKYGPEGQ TVPLTDDELP 450
VALPMEVEVD ASGSPLKKMP AFYDLGEGWT RETDTFDTFM ESSWYYARFA 500
SADNMEAMLD ERADYWLPVD LYIGGIEHAI LHLLYARFFH KLMRDFGLVA 550
SDEPFQRLLT QGMVIAETFY RANDDGSKDW FNPADVDVQR DDKGRPVSAI 600
LREDGQPVEM GGIEKMSKSK NNGVDPQAMI DRFGADTVRL FMMFAAPPEQ 650
SLEWSDSGVE GAHRFLKRLW KLVADHLDAG TPAALDADAL NDDQKTLRRK 700
THETIAKASD DIGRRTTFNT AIAAVMELVN AIGRFEDTSP QGLAVTREAL 750
EACVLVLAPI VPHACHALWD ALGHDTPVID AAWPQADEAA MVKDSVELAV 800
QVNGKLRARL DVPAAADKAA IEAQALEAEN VRRHTEGKTI RKVIVVPGKL 850
VNIVAN 856
Length:856
Mass (Da):95,491
Last modified:May 16, 2006 - v1
Checksum:i37952B02BD302926
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE59693.1.
RefSeqiWP_011507639.1. NC_007963.1.
YP_574392.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE59693; ABE59693; Csal_2344.
GeneIDi4026303.
KEGGicsa:Csal_2344.
PATRICi21448538. VBIChrSal113723_2362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE59693.1 .
RefSeqi WP_011507639.1. NC_007963.1.
YP_574392.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1QV15.
SMRi Q1QV15. Positions 228-411.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290398.Csal_2344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE59693 ; ABE59693 ; Csal_2344 .
GeneIDi 4026303.
KEGGi csa:Csal_2344.
PATRICi 21448538. VBIChrSal113723_2362.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiSYL_CHRSD
AccessioniPrimary (citable) accession number: Q1QV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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