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Q1QV15

- SYL_CHRSD

UniProt

Q1QV15 - SYL_CHRSD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei618 – 6181ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Csal_2344
    OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
    Taxonomic identifieri290398 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
    ProteomesiUP000000239: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Leucine--tRNA ligasePRO_1000009324Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290398.Csal_2344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QV15.
    SMRiQ1QV15. Positions 228-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi615 – 6195"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QV15-1 [UniParc]FASTAAdd to Basket

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    MDAQYTPHAI ESAAQTFWDK NQCFKAVEDA TREKFYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VVSRFQRMQG KNVLQPMGWD AFGMPAENAA IKNRVPPGAW 100
    TYDNIDAMRR QLKALGFAYD WNREFATCDV DYYRWEQWFF TKLVEKGLVY 150
    KKMSTVNWDP VDQTVLANEQ VIEGRGWRSG ALVERKEIPL WFLKITDYAD 200
    ELLADLDKVD WPEQVKTMQR NWIGKSTGVE LSFAVADSSE QLEVYTTRPD 250
    TLYGVTYVAV AAGHPLARQA AQDNPALGDF LEECQQGGNS EAELATMEKK 300
    GMDTGHKAIH PLTGREVPIF VANFVLMEYG TGAVMAVPAH DQRDWEFATK 350
    YGIPIEPVIA DAEGNTPDLS QGAHTEHGKL INSGEFDGLE FDAAFDAIAA 400
    RLEANGQGTV KTNFRLRDWG VARQRYWGAP IPVKYGPEGQ TVPLTDDELP 450
    VALPMEVEVD ASGSPLKKMP AFYDLGEGWT RETDTFDTFM ESSWYYARFA 500
    SADNMEAMLD ERADYWLPVD LYIGGIEHAI LHLLYARFFH KLMRDFGLVA 550
    SDEPFQRLLT QGMVIAETFY RANDDGSKDW FNPADVDVQR DDKGRPVSAI 600
    LREDGQPVEM GGIEKMSKSK NNGVDPQAMI DRFGADTVRL FMMFAAPPEQ 650
    SLEWSDSGVE GAHRFLKRLW KLVADHLDAG TPAALDADAL NDDQKTLRRK 700
    THETIAKASD DIGRRTTFNT AIAAVMELVN AIGRFEDTSP QGLAVTREAL 750
    EACVLVLAPI VPHACHALWD ALGHDTPVID AAWPQADEAA MVKDSVELAV 800
    QVNGKLRARL DVPAAADKAA IEAQALEAEN VRRHTEGKTI RKVIVVPGKL 850
    VNIVAN 856
    Length:856
    Mass (Da):95,491
    Last modified:May 16, 2006 - v1
    Checksum:i37952B02BD302926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE59693.1.
    RefSeqiWP_011507639.1. NC_007963.1.
    YP_574392.1. NC_007963.1.

    Genome annotation databases

    EnsemblBacteriaiABE59693; ABE59693; Csal_2344.
    GeneIDi4026303.
    KEGGicsa:Csal_2344.
    PATRICi21448538. VBIChrSal113723_2362.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE59693.1 .
    RefSeqi WP_011507639.1. NC_007963.1.
    YP_574392.1. NC_007963.1.

    3D structure databases

    ProteinModelPortali Q1QV15.
    SMRi Q1QV15. Positions 228-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290398.Csal_2344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE59693 ; ABE59693 ; Csal_2344 .
    GeneIDi 4026303.
    KEGGi csa:Csal_2344.
    PATRICi 21448538. VBIChrSal113723_2362.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

    Entry informationi

    Entry nameiSYL_CHRSD
    AccessioniPrimary (citable) accession number: Q1QV15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3