Reviewed, UniProtKB/Swiss-Prot Q1QU82 (ALR_CHRSD)

Names and origin

Protein names

Recommended name:
    Alanine racemase
    EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Csal_2629

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Alanine racemase HAMAP MF_01201		PRO_1000065978
Sites
	Active site	35	1	Proton acceptor; specific for D-alanine By similarity
	Active site	256	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	35	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QU82-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 7B5D6BC750957BDD	FASTA	364	39,714
	10 20 30 40 50 60 MSRPLIADID LDALRRNYCL ARDQAPHSRA IAVVKADAYG HGAVACADAL RDLAPAFAVA 70 80 90 100 110 120 CLEEALTLRE AGITQPIVLL EGFFDAAELS LIDAHRLWTA VHSDWQIDAL LAYRPRQPIP 130 140 150 160 170 180 TWLKLDSGMH RLGFAPEAFE ARWQRLAAAT EHVTDLHLMT HFATADALDA AYFRRQMACI 190 200 210 220 230 240 ASLRQRLEAP VCLANSPATL AWPEAHGDWN RPGVMLYGSD PLEGANDASR ALEPVMTLRS 250 260 270 280 290 300 EIIAVRELAE GEAVGYGGRW RASRPSRIGV VAGGYGDGYD RHARDGTPVL VEGQRVPLAG 310 320 330 340 350 360 KVSMDMLTVD LTELPEAGIG SPVVLWGEGL PIDEVARHCD TISYTLMTGV LPRVPRRYRN AETG

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE59976.1.
RefSeq	YP_574675.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4028157.
GenomeReviews	Gene locus Csal_2629 in contig CP000285_GR.
KEGG	csa:Csal_2629.
NMPDR	fig|290398.4.peg.2420.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QU82.
OMA	Q1QU82. TGLKPAM.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_2629-MON.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_CHRSD

Accession

Primary (citable) accession number: Q1QU82

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)