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Q1QU73 (ISPD_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
MEP cytidylyltransferase
Short name=MCT
Gene names
Name:ispD
Ordered Locus Names:Csal_2638
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2492492-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
PRO_1000094321

Sites

Site161Transition state stabilizer By similarity
Site231Transition state stabilizer By similarity
Site1551Positions MEP for the nucleophilic attack By similarity
Site2111Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QU73 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 86D1C76D76E4318A

FASTA24926,875
        10         20         30         40         50         60 
MSRLWLIVPA AGQGRRMGAE CPKQYLDIAG RPVLAHTLAR LHEAFPEAAL RLCLDPDDTR 

        70         80         90        100        110        120 
FSPEWVPFAD WQRVAGGRER VDSVENALAS LADVAADDDL VLVHDVARPC VAVEDLRRLR 

       130        140        150        160        170        180 
EALTTSPEGG LLAAPVADTM KRADARGHVV HTVSREGLWH AMTPQGAPYR VLCRAFAHAR 

       190        200        210        220        230        240 
GAGVVLTDEA SALEAWGLAP RLVPGRRDNL KITHPEDLAL ATRLLAGDPA SRRATGALSD 


DSLADEARS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE59985.1.
RefSeqYP_574684.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QU73.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1QU73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4028166.
GenomeReviewsGene locus Csal_2638 in contig CP000285_GR.
KEGGcsa:Csal_2638.
NMPDRfig|290398.4.peg.2539.
PATRIC21449132. VBIChrSal113723_2653.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1211.
HOGENOMHBG672839.
OMAFPQGAIL.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_2638-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD_CHRSD
AccessionPrimary (citable) accession number: Q1QU73
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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