Reviewed, UniProtKB/Swiss-Prot Q1QTK0 (AROE_CHRSD)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Csal_2862

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Shikimate dehydrogenase		PRO_1000021272
Regions
	Nucleotide binding	128 – 132	5	NADP By similarity
Sites
	Active site	67	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1QTK0-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 1732DC63048AEB7B	FASTA	271	28,705
	10 20 30 40 50 60 MSDDRYCVFG NPVAHSRSPR IHALFAEQCG QAMTYEAIEA PREDFAGAWH AFVAAGGCGA 70 80 90 100 110 120 NVTVPFKEDA FRLADVLSQR ARRAGAVNTL VRGRDGRTYA DTTDGVGLVR DLEAHGVTLE 130 140 150 160 170 180 GARILILGAG GAVRGVLDPL LAKAPSCLHI ANRTASKAVR LAEEASPEGR VTGGGYSELD 190 200 210 220 230 240 GAFDVVINGT SASLGGELPP LPDTLLAADG VAYDMMYAAE PTVFLQWAAA HGGRGIDGLG 250 260 270 MLIEQAAESF FLWRQVRPDT APVRETLRRE L

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE60208.1.
RefSeq	YP_574907.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4028664.
GenomeReviews	Gene locus Csal_2862 in contig CP000285_GR.
KEGG	csa:Csal_2862.
NMPDR	fig|290398.4.peg.2556.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QTK0.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_2862-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CHRSD

Accession

Primary (citable) accession number: Q1QTK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)