Q1QTK0 (AROE_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Csal_2862

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021272
Regions
	Nucleotide binding	128 – 132	5	NADP By similarity
Sites
	Active site	67	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1QTK0 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 1732DC63048AEB7B	FASTA	271	28,705
	10 20 30 40 50 60 MSDDRYCVFG NPVAHSRSPR IHALFAEQCG QAMTYEAIEA PREDFAGAWH AFVAAGGCGA 70 80 90 100 110 120 NVTVPFKEDA FRLADVLSQR ARRAGAVNTL VRGRDGRTYA DTTDGVGLVR DLEAHGVTLE 130 140 150 160 170 180 GARILILGAG GAVRGVLDPL LAKAPSCLHI ANRTASKAVR LAEEASPEGR VTGGGYSELD 190 200 210 220 230 240 GAFDVVINGT SASLGGELPP LPDTLLAADG VAYDMMYAAE PTVFLQWAAA HGGRGIDGLG 250 260 270 MLIEQAAESF FLWRQVRPDT APVRETLRRE L

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000285 Genomic DNA. Translation: ABE60208.1.
RefSeq	YP_574907.1. NC_007963.1.
3D structure databases
ProteinModelPortal	Q1QTK0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QTK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4028664.
GenomeReviews	Gene locus Csal_2862 in contig CP000285_GR.
KEGG	csa:Csal_2862.
NMPDR	fig|290398.4.peg.2556.
PATRIC	21449592. VBIChrSal113723_2882.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_2862-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CHRSD

Accession

Primary (citable) accession number: Q1QTK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program