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Protein

Threonylcarbamoyl-AMP synthase

Gene

tsaC

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO3-/CO2 and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.UniRule annotation

Catalytic activityi

L-threonine + ATP + HCO3- = L-threonylcarbamoyladenylate + diphosphate + H2O.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processtRNA processing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAL290398:G1GJB-2926-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Threonylcarbamoyl-AMP synthaseUniRule annotation (EC:2.7.7.87UniRule annotation)
Short name:
TC-AMP synthaseUniRule annotation
Alternative name(s):
L-threonylcarbamoyladenylate synthaseUniRule annotation
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaCUniRule annotation
tRNA threonylcarbamoyladenosine biosynthesis protein TsaCUniRule annotation
Gene namesi
Name:tsaCUniRule annotation
Synonyms:rimN
Ordered Locus Names:Csal_2864
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003529041 – 185Threonylcarbamoyl-AMP synthaseAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_2864

Structurei

3D structure databases

ProteinModelPortaliQ1QTJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 185YrdC-likeUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the SUA5 family. TsaC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EK0 Bacteria
COG0009 LUCA
HOGENOMiHOG000076163
KOiK07566
OMAiFGLGCNP
OrthoDBiPOG091H00HZ

Family and domain databases

HAMAPiMF_01852 TsaC, 1 hit
InterProiView protein in InterPro
IPR017945 DHBP_synth_RibB-like_a/b_dom
IPR023535 TC-AMP_synthase
IPR006070 YrdC-like_dom
PANTHERiPTHR17490:SF8 PTHR17490:SF8, 1 hit
PfamiView protein in Pfam
PF01300 Sua5_yciO_yrdC, 1 hit
SUPFAMiSSF55821 SSF55821, 1 hit
PROSITEiView protein in PROSITE
PS51163 YRDC, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QTJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQETADRIAD AVAALRRGAL LAYPTEAVWG LGCDPDDDAA LARLIALKQR
60 70 80 90 100
DPAKGLILIA GDMDQLEPWL AGLDALQRAR LAESWPGPNT WLVPDNGRAR
110 120 130 140 150
PLLRGEHTSL AVRVSDHPLV RQLCAAFGGP LVSSSANRAG EPPAMSAADV
160 170 180
RAAFGEAVTL LDGALGGYAR PSTIRDLQSG ETLRR
Length:185
Mass (Da):19,594
Last modified:May 16, 2006 - v1
Checksum:i696616E13879871D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA Translation: ABE60210.1
RefSeqiWP_011508156.1, NC_007963.1

Genome annotation databases

EnsemblBacteriaiABE60210; ABE60210; Csal_2864
KEGGicsa:Csal_2864

Similar proteinsi

Entry informationi

Entry nameiTSAC_CHRSD
AccessioniPrimary (citable) accession number: Q1QTJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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