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Q1QSV5 (Q1QSV5_CHRSD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase HAMAP-Rule MF_00260
Short name=PBG HAMAP-Rule MF_00260
EC=2.5.1.61 HAMAP-Rule MF_00260
Alternative name(s):
Hydroxymethylbilane synthase HAMAP-Rule MF_00260
Pre-uroporphyrinogen synthase HAMAP-Rule MF_00260
Gene names
Name:hemC HAMAP-Rule MF_00260
Ordered Locus Names:Csal_3109 EMBL ABE60453.1
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP] EMBL ABE60453.1
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter ›

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity. HAMAP-Rule MF_00260 SAAS SAAS000860

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP-Rule MF_00260 SAAS SAAS000860

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP-Rule MF_00260 SAAS SAAS000860

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity. HAMAP-Rule MF_00260

Sequence similarities

Belongs to the HMBS family. HAMAP-Rule MF_00260

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2401S-(dipyrrolylmethanemethyl)cysteine By similarity HAMAP-Rule MF_00260

Sequences

Sequence LengthMass (Da)Tools
Q1QSV5 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 23CE102FCF6E47E8

FASTA31133,413
        10         20         30         40         50         60 
MQTLRIATRQ SRLALWQAEH VKARLLALHP GLEVELVAMT TRGDKILDSP LAKVGGKGLF 

        70         80         90        100        110        120 
VKELEEALLD GRADIAVHSM KDVPMHFPEG LGLSVILESG APTDAFVSND YASLDALPEG 

       130        140        150        160        170        180 
VRVGTSSLRR GLQVKEARPD LEVLNLRGNV QTRLGKLDGG EFEAIILATS GLQRLELGHR 

       190        200        210        220        230        240 
ITQELPPEVS LPACGQGALG IECRHDDESL LELLAPLDHP QTATRVRAER AMNTRLDGGC 

       250        260        270        280        290        300 
QVPIGGYAVL EDGDRTLWLR ALVGDPDGSR VLRAEGRGSA DEPEALGVRI AESLLDQGAG 

       310 
DILAQVYDQG E

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE60453.1.
RefSeqYP_575152.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QSV5.
SMRQ1QSV5. Positions 4-307.
ModBaseSearch...

Protein-protein interaction databases

STRING290398.Csal_3109.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE60453; ABE60453; Csal_3109.
GeneID4028750.
KEGGcsa:Csal_3109.
PATRIC21450098. VBIChrSal113723_3127.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0181.
HOGENOMHOG000228588.
KOK01749.
OMACLAERAF.

Family and domain databases

Gene3D3.30.160.40. 1 hit.
HAMAPMF_00260. Porphobil_deam.
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERPTHR11557. PTHR11557. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. Porphobil_deam. 1 hit.
TIGRFAMsTIGR00212. hemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1QSV5_CHRSD
AccessionPrimary (citable) accession number: Q1QSV5
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info