ID   TRMB_CHRSD              Reviewed;         246 AA.
AC   Q1QSR9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase;
DE            EC=2.1.1.33;
DE   AltName: Full=tRNA(m7G46)-methyltransferase;
GN   Name=trmB; OrderedLocusNames=Csal_3145;
OS   Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB
OS   13768).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Chromohalobacter.
OX   NCBI_TaxID=290398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N.,
RA   O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R.,
RA   Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D.,
RA   Canovas D., Richardson P.;
RT   "Complete sequence of Chromohalobacter salexigens DSM 3043.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at
CC       position 46 (m7G46) in tRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-
CC       homocysteine + tRNA containing N(7)-methylguanine.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. TrmB
CC       family.
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DR   EMBL; CP000285; ABE60489.1; -; Genomic_DNA.
DR   RefSeq; YP_575188.1; -.
DR   GeneID; 4028612; -.
DR   GenomeReviews; CP000285_GR; Csal_3145.
DR   KEGG; csa:Csal_3145; -.
DR   NMPDR; fig|290398.4.peg.3137; -.
DR   HOGENOM; Q1QSR9; -.
DR   OMA; Q1QSR9; TKFENRG.
DR   BioCyc; CSAL290398:CSAL_3145-MON; -.
DR   GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006400; P:tRNA modification; IEA:HAMAP.
DR   HAMAP; MF_01057; -; 1.
DR   InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase.
DR   PANTHER; PTHR23417:SF1; Methyltransf_4; 1.
DR   Pfam; PF02390; Methyltransf_4; 1.
DR   TIGRFAMs; TIGR00091; CHP91; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN         1    246       tRNA (guanine-N(7)-)-methyltransferase.
FT                                /FTId=PRO_0000288137.
FT   REGION      224    227       Substrate binding (Potential).
FT   BINDING      74     74       S-adenosyl-L-methionine (By similarity).
FT   BINDING      99     99       S-adenosyl-L-methionine (By similarity).
FT   BINDING     126    126       S-adenosyl-L-methionine (By similarity).
FT   BINDING     149    149       S-adenosyl-L-methionine (By similarity).
FT   BINDING     153    153       Substrate (By similarity).
FT   BINDING     185    185       Substrate (Potential).
SQ   SEQUENCE   246 AA;  27368 MW;  A691A52734B6E9B4 CRC64;
     MSDSSSSSEN APATPESPGR PPRGIKSYVL RAGRMTAAQS RGLEEVWPRL GLSVAEGRQS
     LEALFGRRAP CVVEVGFGMG QSLVEQAAAN PETDFIGIEV HAPGVGKLLD EADKRGLTNL
     RVYRDDALEV LDKCLPESSL TGLQLFFPDP WPKKKHHKRR IVQPAFVELV RTRLAPHGYL
     HMATDWEAYA EHMVEVMEEA PGYRNTAPPE SAPYVPRPEF RPLTKFESRG ERLGHGVWDL
     IYARVE
//