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Q1QSR0

- MASZ_CHRSD

UniProt

Q1QSR0 - MASZ_CHRSD

Protein

Malate synthase G

Gene

glcB

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Binding sitei276 – 2761Acetyl-CoAUniRule annotation
    Binding sitei313 – 3131Acetyl-CoAUniRule annotation
    Active sitei340 – 3401Proton acceptorUniRule annotation
    Binding sitei340 – 3401GlyoxylateUniRule annotation
    Metal bindingi442 – 4421MagnesiumUniRule annotation
    Binding sitei442 – 4421GlyoxylateUniRule annotation
    Metal bindingi470 – 4701MagnesiumUniRule annotation
    Binding sitei551 – 5511Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Active sitei650 – 6501Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-HAMAP
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Name:glcBUniRule annotation
    Ordered Locus Names:Csal_3154
    OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
    Taxonomic identifieri290398 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
    ProteomesiUP000000239: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 742742Malate synthase GPRO_1000056901Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei636 – 6361Cysteine sulfenic acid (-SOH)UniRule annotation
    Modified residuei707 – 7071Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290398.Csal_3154.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QSR0.
    SMRiQ1QSR0. Positions 1-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
    Regioni467 – 4704Glyoxylate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000220740.
    KOiK01638.
    OMAiPANTLKM.
    OrthoDBiEOG6HJ286.

    Family and domain databases

    Gene3Di2.170.170.11. 2 hits.
    HAMAPiMF_00641. Malate_synth_G.
    InterProiIPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1QSR0-1 [UniParc]FASTAAdd to Basket

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    MTDRTTRHRL QVASQLDRFI NDEALPGTGV DPEAFWAGFD ALVHELVPTN    50
    RDLLAERERL QDELDAWHKA NPGPVRDMAA YRAFLKDIGY LVEAPAKVQA 100
    TTANVDDEIA VQAGPQLVVP VSNARYALNA ANARWGSLYD ALYGTDVIPE 150
    TDGAEKSQGY NPKRGEKVIA YARGVLDQAA PLAEGTHAEA SAYALRDGKL 200
    VVTLQGGGET GLADPAQLVG YRGEAQAPTA VLLANHGLHL EVQFDATHPI 250
    GKTDPAHVKD VLVEAAVSTI MDCEDSVAAV DADDKTLVYR NWLGLMKGDL 300
    EERFDKGGKT VTRALNPDRD YTVPGGGELR LPGRSLLFVR NVGHLMTTPA 350
    VLDGDGNEIP EGMLDGVVTS LLAIHDLKKG DGAAPSATAP EAKRNSRTGS 400
    VYIVKPKMHG PREVAFANSL FMRIEDMLGL PRDTLKMGIM DEERRTSINL 450
    DACIHEAASR VAFINTGFLD RTGDEMHTAM EAGPMLRKGE MKGTKWIAAY 500
    EKNNVQTGLA CGLRGRAQIG KGMWAMPELM AAMLEQKIGH PQAGATTAWV 550
    PSPTAAVLHA LHYHQVDVAT IQRELEAKPG GDFLDDLLTV PVVESAASGA 600
    NKSPSWSDDE IQQELDNNCQ GILGYVVRWV EHGVGCSKVP DIHDVGLMED 650
    RATLRISSQH IANWLHHGIV SEARVRETLE RMAKVVDDQN AHDPDYTPMT 700
    SHLAESCAFQ AASDLIFKGR EQPAGYTEPL LHHWRAVHKA KS 742
    Length:742
    Mass (Da):80,564
    Last modified:May 16, 2006 - v1
    Checksum:i52D50E6BAB982917
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE60498.1.
    RefSeqiYP_575197.1. NC_007963.1.

    Genome annotation databases

    EnsemblBacteriaiABE60498; ABE60498; Csal_3154.
    GeneIDi4028621.
    KEGGicsa:Csal_3154.
    PATRICi21450192. VBIChrSal113723_3174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE60498.1 .
    RefSeqi YP_575197.1. NC_007963.1.

    3D structure databases

    ProteinModelPortali Q1QSR0.
    SMRi Q1QSR0. Positions 1-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290398.Csal_3154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE60498 ; ABE60498 ; Csal_3154 .
    GeneIDi 4028621.
    KEGGi csa:Csal_3154.
    PATRICi 21450192. VBIChrSal113723_3174.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000220740.
    KOi K01638.
    OMAi PANTLKM.
    OrthoDBi EOG6HJ286.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .

    Family and domain databases

    Gene3Di 2.170.170.11. 2 hits.
    HAMAPi MF_00641. Malate_synth_G.
    InterProi IPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

    Entry informationi

    Entry nameiMASZ_CHRSD
    AccessioniPrimary (citable) accession number: Q1QSR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3