Reviewed, UniProtKB/Swiss-Prot Q1QSI1 (KGUA_CHRSD)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Csal_3233

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Guanylate kinase HAMAP MF_00328		PRO_0000266306
Regions
	Domain	9 – 187	179	Guanylate kinase-like
	Nucleotide binding	16 – 23	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QSI1-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 93C12AEE5FC8B511	FASTA	215	23,861
	10 20 30 40 50 60 MPIQPPSKGT LYIVSAPSGA GKTSLVRALL ERVAGIQVSV SHTTRAMRPG EQNGINYHFV 70 80 90 100 110 120 DVATFERLIE SGDFIEHARV FDNYYGTSRA AVQALLDAGQ DVILEIDWQG ARQVREAFDE 130 140 150 160 170 180 AVSIFILPPS REALHARLAG RGTDDAATIA RRMRDAVDEM SHYDEYEHVI INDTFDHALD 190 200 210 ELSCLVHAQR TRMPRVQAEH APLLAALLSR VEDVE

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE60577.1.
RefSeq	YP_575276.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QSI1.
Genome annotation databases
GeneID	4028567.
GenomeReviews	Gene locus Csal_3233 in contig CP000285_GR.
KEGG	csa:Csal_3233.
NMPDR	fig|290398.4.peg.1959.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QSI1.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_3233-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CHRSD

Accession

Primary (citable) accession number: Q1QSI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)