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Q1QS64

- IF2_NITHX

UniProt

Q1QS64 - IF2_NITHX

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Protein
Translation initiation factor IF-2
Gene
infB, Nham_0031
Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi374 – 3818GTP By similarity
Nucleotide bindingi421 – 4255GTP By similarity
Nucleotide bindingi475 – 4784GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-31-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:Nham_0031
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 868868Translation initiation factor IF-2UniRule annotation
    PRO_1000008288Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_0031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QS64.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini365 – 535171tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni374 – 3818G1 By similarity
    Regioni399 – 4035G2 By similarity
    Regioni421 – 4244G3 By similarity
    Regioni475 – 4784G4 By similarity
    Regioni511 – 5133G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiHKITDVI.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QS64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDTKNPGDK TLSVGPSKTL TLKPRVEQGT VRQSFSHGRT KQVVVEKRGK    50
    RRIGGDAPAA EPVAASEPTV ARAPRIPVRP APPAASRANS GVVLRTLTED 100
    ERTARASALA EAKIRAEEER RIAEAEAARR NSKEGIEQAE REAAEARRKA 150
    EEERHRQEEE AKRKAELEAK RRFGESETKA APAKTTTTTT RAAPPARPAA 200
    VAADGSDEEE APRLVRRPGG GPARPVVAPK PAAKPAPAKQ RGRLTLVTAL 250
    SADDVRERSI ASFRRRTQRL KGHASNEPKE KLIREVIVPE AITIQELANR 300
    MAERAVDVIR MLMKQGAMHK ITDVIDADTA QLIAEELGHT VKRVAASDVE 350
    EGLFDADDDS TVVEPRSPVV TVMGHVDHGK TSLLDAVRHA NVVSGEAGGI 400
    TQHIGAYQVT SPDGKKITFI DTPGHAAFTA MRARGAKVTD IVVLVVAADD 450
    GVMPQTVEAI NHAKAAKVPM IIAINKIDKP DAKPERVRTE LLQHEVQVES 500
    MGGQVIDVEV SAKNKTNLDK LLEMISLQAD LLDLKTNASR PAEGTVIEAK 550
    LDRGRGPVAT VLVQRGTLRV GDIIVAGAEM GRVRALISDQ GETVDEAGPS 600
    VPVEVLGFNG PPEAGDRLAV VENEARARQV TSYRAHQKRE NAAASSSGMR 650
    GSLEQMMSQL KTAGRKDFPL VIKADVQGSL EAILGSLEKL GTEEVAARIL 700
    HAGVGGISES DVTLAEGFNA AIIGFSVRAN KEAAAAAKRN GIEIRYYNII 750
    YDLVDDVKKA MSGLLAPTLR ETMLGNAEIL EVFNISKVGK VAGCRVTDGN 800
    VERGANVRLI RENVVVHEGK LSTLKRFKDE VKEVQSGQEC GMAFESYHDM 850
    RVGDVIECYR VETIQRSL 868
    Length:868
    Mass (Da):93,501
    Last modified:May 16, 2006 - v1
    Checksum:i8CCA8FA9CA43480D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE60933.1.
    RefSeqiWP_011508640.1. NC_007964.1.
    YP_575393.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE60933; ABE60933; Nham_0031.
    GeneIDi4029798.
    KEGGinha:Nham_0031.
    PATRICi22687361. VBINitHam61822_0724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE60933.1 .
    RefSeqi WP_011508640.1. NC_007964.1.
    YP_575393.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QS64.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_0031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE60933 ; ABE60933 ; Nham_0031 .
    GeneIDi 4029798.
    KEGGi nha:Nham_0031.
    PATRICi 22687361. VBINitHam61822_0724.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi HKITDVI.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci NHAM323097:GHP7-31-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiIF2_NITHX
    AccessioniPrimary (citable) accession number: Q1QS64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: September 3, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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