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Q1QRZ8

- SYL_NITHX

UniProt

Q1QRZ8 - SYL_NITHX

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei633 – 6331ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-99-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Nham_0098
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878878Leucine--tRNA ligasePRO_1000009379Add
    BLAST

    Proteomic databases

    PRIDEiQ1QRZ8.

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_0098.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QRZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi630 – 6345"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QRZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSDRYNARD AEPRWQAAWD QQAIFATKND DPREKYYVLE MFPYPSGRIH    50
    IGHVRNYTLG DVIARYMRAK GYNVLHPMGW DAFGLPAENA AIERKVAPKA 100
    WTYDNIKAMK KQLRSIGLSL DWAREFATCD PSYYKHQQKM FLDFLRAGLA 150
    EREKRKINWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITKYS 200
    QELLEALDTL DRWPDKVRLM QRNWIGRSEG LLLRFALDPA TTPNGEGELK 250
    IFTTRPDTLF GAKFMAIAPD HPLAQAAAKD NPALAEFIAE CKRRGTAQAE 300
    IDTAEKMGFD TGIRAIHPFD PDWTLPVYVA NFILMEYGTG AIFGCPAHDQ 350
    RDLDFVNKYG LGNTPVVCPE GQDPKTLVIT DTAYDGDGRM INSRFLDGMT 400
    AEAAKKEVAK RLESEMRGNM PVGERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CPKCDVVPVP ENDLPVTLPE DVTFDKPGNA LDHHPTWKHV TCPQCGARAT 500
    RETDTMDTFV DSSWYFARFT DPWNETAPTT PEIANRMMPV DQYIGGVEHA 550
    ILHLLYSRFF TRAMKATGHL SMDEPFKGMF TQGMVVHETY RKADGGWASP 600
    DEVGIEAVGN GRRATLISTG EPVEIGAVEK MSKSKRNTVD PDDIIGSYGA 650
    DTARWFMLSD SPPDRDVIWS EEGVQGASRF MQRLWRLVNE SAEAGKAAPR 700
    DKPATFGTDA LALRKAAHGA LDKVSTGIER LHFNVCLANI REFANTLAET 750
    LARFGTRTSD LAPDIAWSLR EAATILVQLF SPMMPHLSEE CWHALGHTGL 800
    VSEARWPQIE RDLLVEDTVT LPVQVNGKKR GEVTVASSAP NPEIETAVLA 850
    LDAVRQALGG KPARKIIIVP QRIVNVVG 878
    Length:878
    Mass (Da):98,481
    Last modified:May 16, 2006 - v1
    Checksum:iE201CAD309F8241A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE60999.1.
    RefSeqiWP_011508706.1. NC_007964.1.
    YP_575459.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE60999; ABE60999; Nham_0098.
    GeneIDi4029599.
    KEGGinha:Nham_0098.
    PATRICi22687513. VBINitHam61822_0799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE60999.1 .
    RefSeqi WP_011508706.1. NC_007964.1.
    YP_575459.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QRZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_0098.

    Proteomic databases

    PRIDEi Q1QRZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE60999 ; ABE60999 ; Nham_0098 .
    GeneIDi 4029599.
    KEGGi nha:Nham_0098.
    PATRICi 22687513. VBINitHam61822_0799.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NHAM323097:GHP7-99-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiSYL_NITHX
    AccessioniPrimary (citable) accession number: Q1QRZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3