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Q1QRZ8

- SYL_NITHX

UniProt

Q1QRZ8 - SYL_NITHX

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Protein
Leucine--tRNA ligase
Gene
leuS, Nham_0098
Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-99-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Nham_0098
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligaseUniRule annotation
PRO_1000009379Add
BLAST

Proteomic databases

PRIDEiQ1QRZ8.

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_0098.

Structurei

3D structure databases

ProteinModelPortaliQ1QRZ8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QRZ8-1 [UniParc]FASTAAdd to Basket

« Hide

MTSDRYNARD AEPRWQAAWD QQAIFATKND DPREKYYVLE MFPYPSGRIH    50
IGHVRNYTLG DVIARYMRAK GYNVLHPMGW DAFGLPAENA AIERKVAPKA 100
WTYDNIKAMK KQLRSIGLSL DWAREFATCD PSYYKHQQKM FLDFLRAGLA 150
EREKRKINWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITKYS 200
QELLEALDTL DRWPDKVRLM QRNWIGRSEG LLLRFALDPA TTPNGEGELK 250
IFTTRPDTLF GAKFMAIAPD HPLAQAAAKD NPALAEFIAE CKRRGTAQAE 300
IDTAEKMGFD TGIRAIHPFD PDWTLPVYVA NFILMEYGTG AIFGCPAHDQ 350
RDLDFVNKYG LGNTPVVCPE GQDPKTLVIT DTAYDGDGRM INSRFLDGMT 400
AEAAKKEVAK RLESEMRGNM PVGERKVNFR LRDWGISRQR YWGCPIPVIH 450
CPKCDVVPVP ENDLPVTLPE DVTFDKPGNA LDHHPTWKHV TCPQCGARAT 500
RETDTMDTFV DSSWYFARFT DPWNETAPTT PEIANRMMPV DQYIGGVEHA 550
ILHLLYSRFF TRAMKATGHL SMDEPFKGMF TQGMVVHETY RKADGGWASP 600
DEVGIEAVGN GRRATLISTG EPVEIGAVEK MSKSKRNTVD PDDIIGSYGA 650
DTARWFMLSD SPPDRDVIWS EEGVQGASRF MQRLWRLVNE SAEAGKAAPR 700
DKPATFGTDA LALRKAAHGA LDKVSTGIER LHFNVCLANI REFANTLAET 750
LARFGTRTSD LAPDIAWSLR EAATILVQLF SPMMPHLSEE CWHALGHTGL 800
VSEARWPQIE RDLLVEDTVT LPVQVNGKKR GEVTVASSAP NPEIETAVLA 850
LDAVRQALGG KPARKIIIVP QRIVNVVG 878
Length:878
Mass (Da):98,481
Last modified:May 16, 2006 - v1
Checksum:iE201CAD309F8241A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE60999.1.
RefSeqiWP_011508706.1. NC_007964.1.
YP_575459.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE60999; ABE60999; Nham_0098.
GeneIDi4029599.
KEGGinha:Nham_0098.
PATRICi22687513. VBINitHam61822_0799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE60999.1 .
RefSeqi WP_011508706.1. NC_007964.1.
YP_575459.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QRZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_0098.

Proteomic databases

PRIDEi Q1QRZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE60999 ; ABE60999 ; Nham_0098 .
GeneIDi 4029599.
KEGGi nha:Nham_0098.
PATRICi 22687513. VBINitHam61822_0799.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NHAM323097:GHP7-99-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiSYL_NITHX
AccessioniPrimary (citable) accession number: Q1QRZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi