Q1QRW8 (COAA_NITHX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	Nham_0128

Organism

Nitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

323097 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Pantothenate kinase HAMAP MF_00215		PRO_1000043235
Regions
	Nucleotide binding	96 – 103	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1QRW8 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 7728A77E2D9C7DD0	FASTA	318	36,280
	10 20 30 40 50 60 MDLRAEQQQY NPYRIFSRSE WAKLRDDMPM TLAADEIAAL RSMHDRLDLT EVEEIYLPLS 70 80 90 100 110 120 RLLSIYVASM QRLFVAQRRF LGIQDRKVPY IIGVAGSVAV GKSTTARVLQ ALLARWSPGP 130 140 150 160 170 180 KVDLITTDGF LFPNAVLERH GLMQKKGFPE SYKLPMLLAF LSDIKAGRAP VRAPVYSHLT 190 200 210 220 230 240 YDIVPKSWIE VSQPDILIVE GVNVLQTGRL PRDGRAVPVV SDFFDFSVYL DAEEPVLRDW 250 260 270 280 290 300 YVKRFLALRD TAFHDPRSYF HRYALLSDDE ATATAIAIWE RTNRANLEDN ILPTRPRATL 310 ILKKGADHVV EQVALRRL

References

[1]

"Complete sequence of chromosome of Nitrobacter hamburgensis X14." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X14 / DSM 10229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000319 Genomic DNA. Translation: ABE61029.1.
RefSeq	YP_575489.1. NC_007964.1.
3D structure databases
ProteinModelPortal	Q1QRW8.
SMR	Q1QRW8. Positions 7-317.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QRW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4029570.
GenomeReviews	Gene locus Nham_0128 in contig CP000319_GR.
KEGG	nha:Nham_0128.
NMPDR	fig|323097.3.peg.503.
PATRIC	22687577. VBINitHam61822_0831.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q1QRW8.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	NHAM323097:NHAM_0128-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_NITHX

Accession

Primary (citable) accession number: Q1QRW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program