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Q1QRR2 (UPPP_NITHX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Nham_0184
OrganismNitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]
Taxonomic identifier323097 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290736

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1QRR2 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: E8917A41F95038CA

FASTA26829,337
        10         20         30         40         50         60 
MFSDAIRAVI LGIVEGVTEF LPVSSTGHLL LAERFFDLGS GNFWNTFTVL IQLGAILAIV 

        70         80         90        100        110        120 
VIYFEKLWRI ALGMFSNDAD RRFVIGVLAA FLPAVVVGLI AGKYIKELLF NPWVVCFSLI 

       130        140        150        160        170        180 
VGGAVLMWVD QLDHKPHEHD ATAFPLPMYI WIGIAQCLAM IPGVSRSGAT IVSAMLLGAD 

       190        200        210        220        230        240 
KRAAAEFSFF LAIPTMIGAF AYDFYKNRAD MTTDHLGIVA IGFVVSFVTA IVVVKAFLSY 

       250        260 
VTRNGFTFFA WWRVIVGTLG LIALALGR 

« Hide

References

[1]"Complete sequence of chromosome of Nitrobacter hamburgensis X14."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X14 / DSM 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000319 Genomic DNA. Translation: ABE61085.1.
RefSeqYP_575545.1. NC_007964.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323097.Nham_0184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE61085; ABE61085; Nham_0184.
GeneID4030778.
KEGGnha:Nham_0184.
PATRIC22687707. VBINitHam61822_0894.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycNHAM323097:GHP7-187-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NITHX
AccessionPrimary (citable) accession number: Q1QRR2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families