ID   HGD_NITHX               Reviewed;         448 AA.
AC   Q1QPR8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   05-MAY-2009, entry version 20.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=Nham_0921;
OS   Nitrobacter hamburgensis (strain X14 / DSM 10229).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Nitrobacter.
OX   NCBI_TaxID=323097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Ward B.,
RA   Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L.,
RA   Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.;
RT   "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000319; ABE61779.1; -; Genomic_DNA.
DR   RefSeq; YP_576239.1; -.
DR   GeneID; 4031915; -.
DR   GenomeReviews; CP000319_GR; Nham_0921.
DR   KEGG; nha:Nham_0921; -.
DR   NMPDR; fig|323097.3.peg.895; -.
DR   HOGENOM; Q1QPR8; -.
DR   OMA; Q1QPR8; HRNCMSE.
DR   BioCyc; NHAM323097:NHAM_0921-MON; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    448       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019531.
FT   METAL       346    346       Iron (By similarity).
FT   METAL       352    352       Iron (By similarity).
FT   METAL       382    382       Iron (By similarity).
SQ   SEQUENCE   448 AA;  49674 MW;  1E4007C93C156DCA CRC64;
     MNTSFDPVAA NSNSANVTPG YMSGFGNSFE TEALPGALPI GRNSPQRCAY GLYAEQLSGS
     PFTAPRGANE RSWLYRIRPS VRHSGHFVKI DAKLWRTAPC LEHDMPLAQL RWDPTPIPED
     ELTFVQSVRT MTTAGDAHTQ TGMAAHIYLI TRSMVDQHFY NADGEMLFVP QGGSLRFVTE
     FGVIDTEPGE IAVIPRGVKF RVEIPSGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF
     LTPVAAYEDD DKPTELFVKW GGALWSTALP HSPIDVVAWH GNYAPYKYDL RTFSPIGAIG
     FDHPDPSIFT VLTSPSEIAG TANIDFVIFP ERWVVAENTF RPPWYHMNVM SEFMGLIYGV
     YDAKPQGFVP GGISLHNCML PHGPDREAFD HASNTELKPV KLTGTLAFMF ETRFPQRVTE
     YAATSDALQD DYADCWQGLE RRFDPTRP
//