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Q1QNS6 (Q1QNS6_NITHX) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoheptose isomerase HAMAP-Rule MF_00067

EC=5.3.1.28 HAMAP-Rule MF_00067
Alternative name(s):
Sedoheptulose 7-phosphate isomerase HAMAP-Rule MF_00067
Gene names
Name:gmhA HAMAP-Rule MF_00067
Ordered Locus Names:Nham_1296 EMBL ABE62121.1
OrganismNitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP] EMBL ABE62121.1
Taxonomic identifier323097 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. SAAS SAAS004515 HAMAP-Rule MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. SAAS SAAS004515 HAMAP-Rule MF_00067

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00067

Subcellular location

Cytoplasm By similarity SAAS SAAS004515 HAMAP-Rule MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP-Rule MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily. HAMAP-Rule MF_00067

Contains 1 SIS domain. HAMAP-Rule MF_00067

Contains SIS domain. SAAS SAAS004515

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain37 – 196160SIS By similarity HAMAP-Rule MF_00067
Region52 – 543Substrate binding By similarity HAMAP-Rule MF_00067
Region94 – 952Substrate binding By similarity HAMAP-Rule MF_00067
Region120 – 1223Substrate binding By similarity HAMAP-Rule MF_00067

Sites

Metal binding611Zinc By similarity HAMAP-Rule MF_00067
Metal binding651Zinc By similarity HAMAP-Rule MF_00067
Metal binding1721Zinc By similarity HAMAP-Rule MF_00067
Metal binding1801Zinc By similarity HAMAP-Rule MF_00067
Binding site651Substrate By similarity HAMAP-Rule MF_00067
Binding site1251Substrate By similarity HAMAP-Rule MF_00067
Binding site1721Substrate By similarity HAMAP-Rule MF_00067

Sequences

Sequence LengthMass (Da)Tools
Q1QNS6 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 60E4F9FAD5CB76A3

FASTA19720,486
        10         20         30         40         50         60 
MSQNQIATHF QQSLAALERA ANDAALLAVT SDIALAIVDA IRSGNKVLLI GNGGSAADAQ 

        70         80         90        100        110        120 
HIASEIVGRY RKERPGYAAV ALTTDTSALT AISNDYGFEQ IFARQVESLG RPGDVLLALS 

       130        140        150        160        170        180 
TSGQSPNILA ALAAARQRGL VIAGFTGLKG KSLHDVCDHL FVAPSDDTPV IQQIHMTAAH 

       190 
AICDSVERAL ADGVGDK 

« Hide

References

[1]"Complete sequence of chromosome of Nitrobacter hamburgensis X14."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X14 / DSM 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000319 Genomic DNA. Translation: ABE62121.1.
RefSeqYP_576581.1. NC_007964.1.

3D structure databases

ProteinModelPortalQ1QNS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323097.Nham_1296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE62121; ABE62121; Nham_1296.
GeneID4032137.
KEGGnha:Nham_1296.
PATRIC22690191. VBINitHam61822_2121.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0279.
HOGENOMHOG000237571.
KOK03271.
OMANDYGFER.
OrthoDBEOG6384PC.
ProtClustDBPRK13937.

Enzyme and pathway databases

BioCycNHAM323097:GHP7-1317-MONOMER.
UniPathwayUPA00041; UER00436.

Family and domain databases

HAMAPMF_00067. GmhA.
InterProIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamPF13580. SIS_2. 1 hit.
[Graphical view]
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1QNS6_NITHX
AccessionPrimary (citable) accession number: Q1QNS6
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)