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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Nham_1618
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi323097.Nham_1618.

Structurei

3D structure databases

ProteinModelPortaliQ1QMW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QMW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAREEPATT FARRHIGPSS RDIAAMLETV GAKSLAALMN EALPPSIRQA
60 70 80 90 100
APLDLGQGLS EGLSETEALA HMQSLAAQNQ AFTSLIGQGY SGTILPAVIQ
110 120 130 140 150
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD
160 170 180 190 200
EATAVAEAMA LAERASSVKT KAFFVDHEVH PQTLAVLRTR AEPLGWTLVT
210 220 230 240 250
GDPLRDLDKA DVFGAVLQYP GTSGVVRDLR PAISTLKAKG GLAVVAADLL
260 270 280 290 300
ALTLLASPGV LGADIAVGSA QRFGVPMGYG GPHAAYMAVR DTLKRLLPGR
310 320 330 340 350
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVISSMYAV
360 370 380 390 400
YHGPEGLAQI ARTVHRRTAT LAAGLTRLGF APLNDAAFDT LTVSVGDRQN
410 420 430 440 450
EIAGRALSQG INLRINADHT LGIALDELTT PEIVEAVWRT FGAAFSYADV
460 470 480 490 500
EAHAPDLLPA DLGRRTAYLT HPVFHAHRSE TELLRYMRKL SDRDLALDRA
510 520 530 540 550
MIPLGSCTMK LNATTEMIPL TWPAFAGLHP FAPCEQAEGY YALFEEFEQW
560 570 580 590 600
LIDITGYDAI SLQPNSGAQG EYAGLLAIRG YHAARGDSHR TVCLIPSSAH
610 620 630 640 650
GTNPASANMA GMEVVVVACD ARGDVDVDDL RAKAAQHADR LAAIMITYPS
660 670 680 690 700
THGVFEERIR EICDIVHSHG GQVYLDGANM NAQVGLSRPG DYGADVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGMGPIG VKAHLASFLP GHPATDGATP PAVGAVSAAP
760 770 780 790 800
FGSASILTIS YIYVLMMGGE GLTRATEVAI LNANYVAQRL DPHFPVLYRN
810 820 830 840 850
VKGRVAHECI IDPRALKAET GVTVDDIAKR LIDYGFHAPT MSFPVPGTLM
860 870 880 890 900
IEPTESESKA ELDRFCDAMI AIRREIAEIE AGRWSVEASP LRHAPHTVHD
910 920 930 940 950
IADDTWSRPY SRAQGCFPAG TSRLDKYWCP VGRVDNAYGD RNLVCSCPPM

EDYAQAAE
Length:958
Mass (Da):102,759
Last modified:May 16, 2006 - v1
Checksum:iAAD18BBFE8AD77A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62437.1.
RefSeqiWP_011510122.1. NC_007964.1.
YP_576897.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62437; ABE62437; Nham_1618.
GeneIDi4033310.
KEGGinha:Nham_1618.
PATRICi22690885. VBINitHam61822_2465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62437.1.
RefSeqiWP_011510122.1. NC_007964.1.
YP_576897.1. NC_007964.1.

3D structure databases

ProteinModelPortaliQ1QMW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323097.Nham_1618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE62437; ABE62437; Nham_1618.
GeneIDi4033310.
KEGGinha:Nham_1618.
PATRICi22690885. VBINitHam61822_2465.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1643-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiGCSP_NITHX
AccessioniPrimary (citable) accession number: Q1QMW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: March 4, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.