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Q1QMW0 (GCSP_NITHX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Nham_1618
OrganismNitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]
Taxonomic identifier323097 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045593

Amino acid modifications

Modified residue7031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QMW0 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: AAD18BBFE8AD77A1

FASTA958102,759
        10         20         30         40         50         60 
MTAREEPATT FARRHIGPSS RDIAAMLETV GAKSLAALMN EALPPSIRQA APLDLGQGLS 

        70         80         90        100        110        120 
EGLSETEALA HMQSLAAQNQ AFTSLIGQGY SGTILPAVIQ RNILENPAWY TAYTPYQPEI 

       130        140        150        160        170        180 
SQGRLEALFN FQTMICDLTG LDVANASLLD EATAVAEAMA LAERASSVKT KAFFVDHEVH 

       190        200        210        220        230        240 
PQTLAVLRTR AEPLGWTLVT GDPLRDLDKA DVFGAVLQYP GTSGVVRDLR PAISTLKAKG 

       250        260        270        280        290        300 
GLAVVAADLL ALTLLASPGV LGADIAVGSA QRFGVPMGYG GPHAAYMAVR DTLKRLLPGR 

       310        320        330        340        350        360 
IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVISSMYAV YHGPEGLAQI 

       370        380        390        400        410        420 
ARTVHRRTAT LAAGLTRLGF APLNDAAFDT LTVSVGDRQN EIAGRALSQG INLRINADHT 

       430        440        450        460        470        480 
LGIALDELTT PEIVEAVWRT FGAAFSYADV EAHAPDLLPA DLGRRTAYLT HPVFHAHRSE 

       490        500        510        520        530        540 
TELLRYMRKL SDRDLALDRA MIPLGSCTMK LNATTEMIPL TWPAFAGLHP FAPCEQAEGY 

       550        560        570        580        590        600 
YALFEEFEQW LIDITGYDAI SLQPNSGAQG EYAGLLAIRG YHAARGDSHR TVCLIPSSAH 

       610        620        630        640        650        660 
GTNPASANMA GMEVVVVACD ARGDVDVDDL RAKAAQHADR LAAIMITYPS THGVFEERIR 

       670        680        690        700        710        720 
EICDIVHSHG GQVYLDGANM NAQVGLSRPG DYGADVSHLN LHKTFCIPHG GGGPGMGPIG 

       730        740        750        760        770        780 
VKAHLASFLP GHPATDGATP PAVGAVSAAP FGSASILTIS YIYVLMMGGE GLTRATEVAI 

       790        800        810        820        830        840 
LNANYVAQRL DPHFPVLYRN VKGRVAHECI IDPRALKAET GVTVDDIAKR LIDYGFHAPT 

       850        860        870        880        890        900 
MSFPVPGTLM IEPTESESKA ELDRFCDAMI AIRREIAEIE AGRWSVEASP LRHAPHTVHD 

       910        920        930        940        950 
IADDTWSRPY SRAQGCFPAG TSRLDKYWCP VGRVDNAYGD RNLVCSCPPM EDYAQAAE 

« Hide

References

[1]"Complete sequence of chromosome of Nitrobacter hamburgensis X14."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X14 / DSM 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000319 Genomic DNA. Translation: ABE62437.1.
RefSeqYP_576897.1. NC_007964.1.

3D structure databases

ProteinModelPortalQ1QMW0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323097.Nham_1618.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE62437; ABE62437; Nham_1618.
GeneID4033310.
KEGGnha:Nham_1618.
PATRIC22690885. VBINitHam61822_2465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMATAYLTHP.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycNHAM323097:GHP7-1643-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NITHX
AccessionPrimary (citable) accession number: Q1QMW0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families