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Q1QMW0

- GCSP_NITHX

UniProt

Q1QMW0 - GCSP_NITHX

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-1643-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Nham_1618
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi323097.Nham_1618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QMW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1QMW0-1 [UniParc]FASTAAdd to Basket

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    MTAREEPATT FARRHIGPSS RDIAAMLETV GAKSLAALMN EALPPSIRQA    50
    APLDLGQGLS EGLSETEALA HMQSLAAQNQ AFTSLIGQGY SGTILPAVIQ 100
    RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
    EATAVAEAMA LAERASSVKT KAFFVDHEVH PQTLAVLRTR AEPLGWTLVT 200
    GDPLRDLDKA DVFGAVLQYP GTSGVVRDLR PAISTLKAKG GLAVVAADLL 250
    ALTLLASPGV LGADIAVGSA QRFGVPMGYG GPHAAYMAVR DTLKRLLPGR 300
    IVGLSVDSRG APAYRLALQT REQHIRREKA TSNICTAQVL LAVISSMYAV 350
    YHGPEGLAQI ARTVHRRTAT LAAGLTRLGF APLNDAAFDT LTVSVGDRQN 400
    EIAGRALSQG INLRINADHT LGIALDELTT PEIVEAVWRT FGAAFSYADV 450
    EAHAPDLLPA DLGRRTAYLT HPVFHAHRSE TELLRYMRKL SDRDLALDRA 500
    MIPLGSCTMK LNATTEMIPL TWPAFAGLHP FAPCEQAEGY YALFEEFEQW 550
    LIDITGYDAI SLQPNSGAQG EYAGLLAIRG YHAARGDSHR TVCLIPSSAH 600
    GTNPASANMA GMEVVVVACD ARGDVDVDDL RAKAAQHADR LAAIMITYPS 650
    THGVFEERIR EICDIVHSHG GQVYLDGANM NAQVGLSRPG DYGADVSHLN 700
    LHKTFCIPHG GGGPGMGPIG VKAHLASFLP GHPATDGATP PAVGAVSAAP 750
    FGSASILTIS YIYVLMMGGE GLTRATEVAI LNANYVAQRL DPHFPVLYRN 800
    VKGRVAHECI IDPRALKAET GVTVDDIAKR LIDYGFHAPT MSFPVPGTLM 850
    IEPTESESKA ELDRFCDAMI AIRREIAEIE AGRWSVEASP LRHAPHTVHD 900
    IADDTWSRPY SRAQGCFPAG TSRLDKYWCP VGRVDNAYGD RNLVCSCPPM 950
    EDYAQAAE 958
    Length:958
    Mass (Da):102,759
    Last modified:May 16, 2006 - v1
    Checksum:iAAD18BBFE8AD77A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62437.1.
    RefSeqiYP_576897.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE62437; ABE62437; Nham_1618.
    GeneIDi4033310.
    KEGGinha:Nham_1618.
    PATRICi22690885. VBINitHam61822_2465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62437.1 .
    RefSeqi YP_576897.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QMW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_1618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE62437 ; ABE62437 ; Nham_1618 .
    GeneIDi 4033310.
    KEGGi nha:Nham_1618.
    PATRICi 22690885. VBINitHam61822_2465.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci NHAM323097:GHP7-1643-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiGCSP_NITHX
    AccessioniPrimary (citable) accession number: Q1QMW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3