Q1QMM4 (LPXB_NITHX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	Nham_1707

Organism

Nitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

323097 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter › Nitrobacter hamburgensis

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255201

Sequences

	Sequence		Length	Mass (Da)
	Q1QMM4 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: FD838EA70425C56F	FASTA	396	43,700
	10 20 30 40 50 60 MADGTAANSS RRIFLIATEE SGDRLGSSLM KVLRRRLDDA VRFEGVGGRS MAREGLVSLF 70 80 90 100 110 120 PIEDLSIMGF AAVVKQLPMI LRRIRETADA VIAAEPDMLV IIDSPDFTHR VARRVRARRP 130 140 150 160 170 180 ALPIVDYVSP SVWAWRPGRA RAMRRYVDHV LALLPFEPEE YRRLAGPPCT YVGHPLIEQV 190 200 210 220 230 240 GMLRPDAQER QRRDAPPPAL LVLPGSRRSE IDHHMAVFGE TLRTLQLDAG EMDVVLLTMP 250 260 270 280 290 300 HLIEKVKAAV ASWPLQPRIV VGEQGKQAAF RVARAALTKS GTVTLELALA GVPMVTAYRG 310 320 330 340 350 360 GAVEAWIAQR VIRTSSVILA NLVIGENVIP EFLQENCTPE NLAPALREIL TDSPLRRRQL 370 380 390 KAFAKLDAIM ATGQHSPSER AADIVLETMH ASRGPE

References

[1]

"Complete sequence of chromosome of Nitrobacter hamburgensis X14." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X14 / DSM 10229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000319 Genomic DNA. Translation: ABE62523.1.
RefSeq	YP_576983.1. NC_007964.1.
3D structure databases
ProteinModelPortal	Q1QMM4.
ModBase	Search...
Protein-protein interaction databases
STRING	323097.Nham_1707.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE62523; ABE62523; Nham_1707.
GeneID	4030307.
KEGG	nha:Nham_1707.
PATRIC	22691076. VBINitHam61822_2560.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	CLSK911278.
Enzyme and pathway databases
BioCyc	NHAM323097:GHP7-1775-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_NITHX

Accession

Primary (citable) accession number: Q1QMM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program