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Q1QMM4

- LPXB_NITHX

UniProt

Q1QMM4 - LPXB_NITHX

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-1734-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Nham_1707
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Lipid-A-disaccharide synthasePRO_0000255201Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_1707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QMM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1QMM4-1 [UniParc]FASTAAdd to Basket

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    MADGTAANSS RRIFLIATEE SGDRLGSSLM KVLRRRLDDA VRFEGVGGRS    50
    MAREGLVSLF PIEDLSIMGF AAVVKQLPMI LRRIRETADA VIAAEPDMLV 100
    IIDSPDFTHR VARRVRARRP ALPIVDYVSP SVWAWRPGRA RAMRRYVDHV 150
    LALLPFEPEE YRRLAGPPCT YVGHPLIEQV GMLRPDAQER QRRDAPPPAL 200
    LVLPGSRRSE IDHHMAVFGE TLRTLQLDAG EMDVVLLTMP HLIEKVKAAV 250
    ASWPLQPRIV VGEQGKQAAF RVARAALTKS GTVTLELALA GVPMVTAYRG 300
    GAVEAWIAQR VIRTSSVILA NLVIGENVIP EFLQENCTPE NLAPALREIL 350
    TDSPLRRRQL KAFAKLDAIM ATGQHSPSER AADIVLETMH ASRGPE 396
    Length:396
    Mass (Da):43,700
    Last modified:May 16, 2006 - v1
    Checksum:iFD838EA70425C56F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62523.1.
    RefSeqiYP_576983.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE62523; ABE62523; Nham_1707.
    GeneIDi4030307.
    KEGGinha:Nham_1707.
    PATRICi22691076. VBINitHam61822_2560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62523.1 .
    RefSeqi YP_576983.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QMM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_1707.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE62523 ; ABE62523 ; Nham_1707 .
    GeneIDi 4030307.
    KEGGi nha:Nham_1707.
    PATRICi 22691076. VBINitHam61822_2560.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci NHAM323097:GHP7-1734-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiLPXB_NITHX
    AccessioniPrimary (citable) accession number: Q1QMM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3