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Q1QMM4

- LPXB_NITHX

UniProt

Q1QMM4 - LPXB_NITHX

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1734-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Nham_1707
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Lipid-A-disaccharide synthasePRO_0000255201Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_1707.

Structurei

3D structure databases

ProteinModelPortaliQ1QMM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QMM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGTAANSS RRIFLIATEE SGDRLGSSLM KVLRRRLDDA VRFEGVGGRS
60 70 80 90 100
MAREGLVSLF PIEDLSIMGF AAVVKQLPMI LRRIRETADA VIAAEPDMLV
110 120 130 140 150
IIDSPDFTHR VARRVRARRP ALPIVDYVSP SVWAWRPGRA RAMRRYVDHV
160 170 180 190 200
LALLPFEPEE YRRLAGPPCT YVGHPLIEQV GMLRPDAQER QRRDAPPPAL
210 220 230 240 250
LVLPGSRRSE IDHHMAVFGE TLRTLQLDAG EMDVVLLTMP HLIEKVKAAV
260 270 280 290 300
ASWPLQPRIV VGEQGKQAAF RVARAALTKS GTVTLELALA GVPMVTAYRG
310 320 330 340 350
GAVEAWIAQR VIRTSSVILA NLVIGENVIP EFLQENCTPE NLAPALREIL
360 370 380 390
TDSPLRRRQL KAFAKLDAIM ATGQHSPSER AADIVLETMH ASRGPE
Length:396
Mass (Da):43,700
Last modified:May 16, 2006 - v1
Checksum:iFD838EA70425C56F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62523.1.
RefSeqiWP_011510205.1. NC_007964.1.
YP_576983.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62523; ABE62523; Nham_1707.
GeneIDi4030307.
KEGGinha:Nham_1707.
PATRICi22691076. VBINitHam61822_2560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62523.1 .
RefSeqi WP_011510205.1. NC_007964.1.
YP_576983.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QMM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_1707.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE62523 ; ABE62523 ; Nham_1707 .
GeneIDi 4030307.
KEGGi nha:Nham_1707.
PATRICi 22691076. VBINitHam61822_2560.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci NHAM323097:GHP7-1734-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiLPXB_NITHX
AccessioniPrimary (citable) accession number: Q1QMM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3