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Q1QMC9

- TRMFO_NITHX

UniProt

Q1QMC9 - TRMFO_NITHX

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FADUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Nham_1804
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_1804.

Structurei

3D structure databases

ProteinModelPortaliQ1QMC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiWEMRAAG.
OrthoDBiEOG6J74VT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QMC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQIELSCSA VHIIGAGLAG SEAAWQVANH GVRVVLHEMR PHRMTAAHQT
60 70 80 90 100
GGLAELVCSN SFRSDDAANN AVGLLHAEMR RLGSLIMRCA DANQVPAGGA
110 120 130 140 150
LAVDRDGFSS AVTKALDDHP LIEINRTEVD GLPPADWRNV IVATGPLTSA
160 170 180 190 200
PLAAAIRALT DESALAFFDA IAPIVHRDSI DMSKAWFQSR YDKVGPGGTG
210 220 230 240 250
ADYINCPMTE AQYHAFVDAL IEGEKVDFKD WEIDTPYFDG CLPIEIMAER
260 270 280 290 300
GRETLRHGPM KPVGLTNPHD PTVKPYAIVQ LRQDNRLGTL YNIVGFQTKL
310 320 330 340 350
KHGAQTRVFR TIPGLETAEF ARLGGLHRNT FLNSPKLLDT QLRLRAEPRL
360 370 380 390 400
RFAGQMTGCE GYVESAAIGL IAGLYAASDA RARSLAAPPP TTALGALLGH
410 420 430 440 450
ITGGHIESID AGPRSFQPMN INFGLFPPLA NPPAKKPDGT RLRGNEKTIA
460 470
KKQAISARAL ADLDRWIADA LRVAAAA
Length:477
Mass (Da):51,271
Last modified:May 16, 2006 - v1
Checksum:i0BE127CFBCA17572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62618.1.
RefSeqiWP_011510300.1. NC_007964.1.
YP_577078.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62618; ABE62618; Nham_1804.
GeneIDi4032981.
KEGGinha:Nham_1804.
PATRICi22691296. VBINitHam61822_2668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62618.1 .
RefSeqi WP_011510300.1. NC_007964.1.
YP_577078.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QMC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_1804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE62618 ; ABE62618 ; Nham_1804 .
GeneIDi 4032981.
KEGGi nha:Nham_1804.
PATRICi 22691296. VBINitHam61822_2668.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi WEMRAAG.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci NHAM323097:GHP7-1833-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiTRMFO_NITHX
AccessioniPrimary (citable) accession number: Q1QMC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3