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Q1QMC9

- TRMFO_NITHX

UniProt

Q1QMC9 - TRMFO_NITHX

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 206FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-1833-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:Nham_1804
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346367Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_1804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QMC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiWEMRAAG.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QMC9-1 [UniParc]FASTAAdd to Basket

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    MTQIELSCSA VHIIGAGLAG SEAAWQVANH GVRVVLHEMR PHRMTAAHQT    50
    GGLAELVCSN SFRSDDAANN AVGLLHAEMR RLGSLIMRCA DANQVPAGGA 100
    LAVDRDGFSS AVTKALDDHP LIEINRTEVD GLPPADWRNV IVATGPLTSA 150
    PLAAAIRALT DESALAFFDA IAPIVHRDSI DMSKAWFQSR YDKVGPGGTG 200
    ADYINCPMTE AQYHAFVDAL IEGEKVDFKD WEIDTPYFDG CLPIEIMAER 250
    GRETLRHGPM KPVGLTNPHD PTVKPYAIVQ LRQDNRLGTL YNIVGFQTKL 300
    KHGAQTRVFR TIPGLETAEF ARLGGLHRNT FLNSPKLLDT QLRLRAEPRL 350
    RFAGQMTGCE GYVESAAIGL IAGLYAASDA RARSLAAPPP TTALGALLGH 400
    ITGGHIESID AGPRSFQPMN INFGLFPPLA NPPAKKPDGT RLRGNEKTIA 450
    KKQAISARAL ADLDRWIADA LRVAAAA 477
    Length:477
    Mass (Da):51,271
    Last modified:May 16, 2006 - v1
    Checksum:i0BE127CFBCA17572
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62618.1.
    RefSeqiYP_577078.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE62618; ABE62618; Nham_1804.
    GeneIDi4032981.
    KEGGinha:Nham_1804.
    PATRICi22691296. VBINitHam61822_2668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62618.1 .
    RefSeqi YP_577078.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QMC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_1804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE62618 ; ABE62618 ; Nham_1804 .
    GeneIDi 4032981.
    KEGGi nha:Nham_1804.
    PATRICi 22691296. VBINitHam61822_2668.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi WEMRAAG.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci NHAM323097:GHP7-1833-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiTRMFO_NITHX
    AccessioniPrimary (citable) accession number: Q1QMC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3