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Q1QMC9

- TRMFO_NITHX

UniProt

Q1QMC9 - TRMFO_NITHX

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene
trmFO, Nham_1804
Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206FAD By similarity

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC:2.1.1.74)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:trmFO
Ordered Locus Names:Nham_1804
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotationPRO_0000346367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_1804.

Structurei

3D structure databases

ProteinModelPortaliQ1QMC9.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiWEMRAAG.
OrthoDBiEOG6J74VT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QMC9-1 [UniParc]FASTAAdd to Basket

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MTQIELSCSA VHIIGAGLAG SEAAWQVANH GVRVVLHEMR PHRMTAAHQT    50
GGLAELVCSN SFRSDDAANN AVGLLHAEMR RLGSLIMRCA DANQVPAGGA 100
LAVDRDGFSS AVTKALDDHP LIEINRTEVD GLPPADWRNV IVATGPLTSA 150
PLAAAIRALT DESALAFFDA IAPIVHRDSI DMSKAWFQSR YDKVGPGGTG 200
ADYINCPMTE AQYHAFVDAL IEGEKVDFKD WEIDTPYFDG CLPIEIMAER 250
GRETLRHGPM KPVGLTNPHD PTVKPYAIVQ LRQDNRLGTL YNIVGFQTKL 300
KHGAQTRVFR TIPGLETAEF ARLGGLHRNT FLNSPKLLDT QLRLRAEPRL 350
RFAGQMTGCE GYVESAAIGL IAGLYAASDA RARSLAAPPP TTALGALLGH 400
ITGGHIESID AGPRSFQPMN INFGLFPPLA NPPAKKPDGT RLRGNEKTIA 450
KKQAISARAL ADLDRWIADA LRVAAAA 477
Length:477
Mass (Da):51,271
Last modified:May 16, 2006 - v1
Checksum:i0BE127CFBCA17572
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE62618.1.
RefSeqiYP_577078.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62618; ABE62618; Nham_1804.
GeneIDi4032981.
KEGGinha:Nham_1804.
PATRICi22691296. VBINitHam61822_2668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE62618.1 .
RefSeqi YP_577078.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QMC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_1804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE62618 ; ABE62618 ; Nham_1804 .
GeneIDi 4032981.
KEGGi nha:Nham_1804.
PATRICi 22691296. VBINitHam61822_2668.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi WEMRAAG.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci NHAM323097:GHP7-1833-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiTRMFO_NITHX
AccessioniPrimary (citable) accession number: Q1QMC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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