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Protein

Putative thymidine phosphorylase

Gene

Nham_1900

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1929-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Ordered Locus Names:Nham_1900
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Putative thymidine phosphorylasePRO_0000314704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_1900.

Structurei

3D structure databases

ProteinModelPortaliQ1QM39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QM39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGTDLPRLQ PKIRRVNLDT GRENVVVISR HSAALRPEIF RGFSRVELRR
60 70 80 90 100
NAKIMLATLI ITDDDSLVGP DDLGLSEPAF RRFAEPVGSA VTIAPAASPA
110 120 130 140 150
SLDAVRAKIM GQTFSAVDIS AIIDDLTHYR YSDMEIAAFL ISSASFMTNG
160 170 180 190 200
ELIALVDSMA RAGTQLKWRN PIIVDKHCIG GIPGNRTSMI VVPIVAAHGL
210 220 230 240 250
TIPKTSSRAI TSPAGTADTM EMLARVDVGV EEMKDIVAAC RGCLVWGGHV
260 270 280 290 300
NLSPADDILI SVERPLGLDT REQMVASILS KKLAAGSTHL LIDLPVGPTA
310 320 330 340 350
KLVNEMEAMR LRKLFEFVGD HYGISVEVVV TDGRQPIGNG IGPVLEAQDV
360 370 380 390 400
MAVLANDPEA PADLREKSLR LAAHLLEYDP KLRGGSGYAR ARELLDSGAA
410 420 430 440 450
LKQMQKIIDA QGPPTCCTDL GNLTFDVTAS RDGFVSGINC LQLNRLARIA
460 470 480 490 500
GAPIDKGAGI RLFKKIGDRV QQGEPLYRIH AFERSGRDLA AAGTTAYTID
510
SEESNLEATP
Length:510
Mass (Da):54,756
Last modified:January 15, 2008 - v2
Checksum:i787647AD246C0489
GO

Sequence cautioni

The sequence ABE62708.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62708.1. Different initiation.
RefSeqiWP_041357912.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62708; ABE62708; Nham_1900.
KEGGinha:Nham_1900.
PATRICi22691488. VBINitHam61822_2764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE62708.1. Different initiation.
RefSeqiWP_041357912.1. NC_007964.1.

3D structure databases

ProteinModelPortaliQ1QM39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323097.Nham_1900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE62708; ABE62708; Nham_1900.
KEGGinha:Nham_1900.
PATRICi22691488. VBINitHam61822_2764.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OrthoDBiEOG61ZTGG.

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-1929-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiTYPH_NITHX
AccessioniPrimary (citable) accession number: Q1QM39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.