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Q1QM39

- TYPH_NITHX

UniProt

Q1QM39 - TYPH_NITHX

Protein

Putative thymidine phosphorylase

Gene

Nham_1900

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-1929-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Nham_1900
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Putative thymidine phosphorylasePRO_0000314704Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_1900.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QM39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QM39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGTDLPRLQ PKIRRVNLDT GRENVVVISR HSAALRPEIF RGFSRVELRR    50
    NAKIMLATLI ITDDDSLVGP DDLGLSEPAF RRFAEPVGSA VTIAPAASPA 100
    SLDAVRAKIM GQTFSAVDIS AIIDDLTHYR YSDMEIAAFL ISSASFMTNG 150
    ELIALVDSMA RAGTQLKWRN PIIVDKHCIG GIPGNRTSMI VVPIVAAHGL 200
    TIPKTSSRAI TSPAGTADTM EMLARVDVGV EEMKDIVAAC RGCLVWGGHV 250
    NLSPADDILI SVERPLGLDT REQMVASILS KKLAAGSTHL LIDLPVGPTA 300
    KLVNEMEAMR LRKLFEFVGD HYGISVEVVV TDGRQPIGNG IGPVLEAQDV 350
    MAVLANDPEA PADLREKSLR LAAHLLEYDP KLRGGSGYAR ARELLDSGAA 400
    LKQMQKIIDA QGPPTCCTDL GNLTFDVTAS RDGFVSGINC LQLNRLARIA 450
    GAPIDKGAGI RLFKKIGDRV QQGEPLYRIH AFERSGRDLA AAGTTAYTID 500
    SEESNLEATP 510
    Length:510
    Mass (Da):54,756
    Last modified:January 15, 2008 - v2
    Checksum:i787647AD246C0489
    GO

    Sequence cautioni

    The sequence ABE62708.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62708.1. Different initiation.
    RefSeqiYP_577168.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE62708; ABE62708; Nham_1900.
    GeneIDi4033038.
    KEGGinha:Nham_1900.
    PATRICi22691488. VBINitHam61822_2764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62708.1 . Different initiation.
    RefSeqi YP_577168.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QM39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_1900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE62708 ; ABE62708 ; Nham_1900 .
    GeneIDi 4033038.
    KEGGi nha:Nham_1900.
    PATRICi 22691488. VBINitHam61822_2764.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    BioCyci NHAM323097:GHP7-1929-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiTYPH_NITHX
    AccessioniPrimary (citable) accession number: Q1QM39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3