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Q1QLI2

- PUR5_NITHX

UniProt

Q1QLI2 - PUR5_NITHX

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-2150-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Nham_2118
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_2118.

Structurei

3D structure databases

ProteinModelPortaliQ1QLI2.
SMRiQ1QLI2. Positions 7-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QLI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDRKNGLTY ADAGVDIDAG NRLVDLIKPM VRATARAGAD AEIGGFGGLF
60 70 80 90 100
DLKAAGFTDP VLVAANDGVG TKVKIAIETG IHDTIGIDLV AMSVNDLVVQ
110 120 130 140 150
GAEPLFFLDY FACGKLDPEV ASAIVAGIAV GCREAGCALI GGETAEMPGL
160 170 180 190 200
YKDGDYDLAG FAVGAAERGT LLPGRDIAAG DAVIGLASSG VHSNGYSLVR
210 220 230 240 250
KIVEASGLGF SVPAPFAPVT TLGGALLTPT RLYVKSCLRA IRETGAVKGL
260 270 280 290 300
AHITGGGFTD NIPRVLPKHL GIRIDLSRLT VLPVFKWLAR QGGIAELELL
310 320 330 340 350
RTFNCGVGMI AIVRRDAVEQ VVDVLTQAGE RVAPLGSVIE ASGDRVVYDN

HLDLAM
Length:356
Mass (Da):36,865
Last modified:May 16, 2006 - v1
Checksum:iDE64E8037E52275D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE62915.1.
RefSeqiWP_011510594.1. NC_007964.1.
YP_577375.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE62915; ABE62915; Nham_2118.
GeneIDi4031948.
KEGGinha:Nham_2118.
PATRICi22691976. VBINitHam61822_3005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE62915.1 .
RefSeqi WP_011510594.1. NC_007964.1.
YP_577375.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QLI2.
SMRi Q1QLI2. Positions 7-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_2118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE62915 ; ABE62915 ; Nham_2118 .
GeneIDi 4031948.
KEGGi nha:Nham_2118.
PATRICi 22691976. VBINitHam61822_3005.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci NHAM323097:GHP7-2150-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiPUR5_NITHX
AccessioniPrimary (citable) accession number: Q1QLI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3