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Q1QLI2

- PUR5_NITHX

UniProt

Q1QLI2 - PUR5_NITHX

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNHAM323097:GHP7-2150-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Nham_2118
    OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
    Taxonomic identifieri323097 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
    ProteomesiUP000001953: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148288Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323097.Nham_2118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QLI2.
    SMRiQ1QLI2. Positions 7-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiGEATCEV.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1QLI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDRKNGLTY ADAGVDIDAG NRLVDLIKPM VRATARAGAD AEIGGFGGLF    50
    DLKAAGFTDP VLVAANDGVG TKVKIAIETG IHDTIGIDLV AMSVNDLVVQ 100
    GAEPLFFLDY FACGKLDPEV ASAIVAGIAV GCREAGCALI GGETAEMPGL 150
    YKDGDYDLAG FAVGAAERGT LLPGRDIAAG DAVIGLASSG VHSNGYSLVR 200
    KIVEASGLGF SVPAPFAPVT TLGGALLTPT RLYVKSCLRA IRETGAVKGL 250
    AHITGGGFTD NIPRVLPKHL GIRIDLSRLT VLPVFKWLAR QGGIAELELL 300
    RTFNCGVGMI AIVRRDAVEQ VVDVLTQAGE RVAPLGSVIE ASGDRVVYDN 350
    HLDLAM 356
    Length:356
    Mass (Da):36,865
    Last modified:May 16, 2006 - v1
    Checksum:iDE64E8037E52275D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62915.1.
    RefSeqiWP_011510594.1. NC_007964.1.
    YP_577375.1. NC_007964.1.

    Genome annotation databases

    EnsemblBacteriaiABE62915; ABE62915; Nham_2118.
    GeneIDi4031948.
    KEGGinha:Nham_2118.
    PATRICi22691976. VBINitHam61822_3005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000319 Genomic DNA. Translation: ABE62915.1 .
    RefSeqi WP_011510594.1. NC_007964.1.
    YP_577375.1. NC_007964.1.

    3D structure databases

    ProteinModelPortali Q1QLI2.
    SMRi Q1QLI2. Positions 7-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323097.Nham_2118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE62915 ; ABE62915 ; Nham_2118 .
    GeneIDi 4031948.
    KEGGi nha:Nham_2118.
    PATRICi 22691976. VBINitHam61822_3005.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi GEATCEV.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci NHAM323097:GHP7-2150-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X14 / DSM 10229.

    Entry informationi

    Entry nameiPUR5_NITHX
    AccessioniPrimary (citable) accession number: Q1QLI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3