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Q1QIG6 (Q1QIG6_NITHX) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:Nham_3246
OrganismNitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]
Taxonomic identifier323097 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region68 – 7710Important for dimerization By similarity HAMAP MF_00333
Region128 – 1303Substrate binding By similarity HAMAP MF_00333
Region260 – 29536Important for dimerization By similarity HAMAP MF_00333
Region278 – 2836Substrate binding By similarity HAMAP MF_00333

Sites

Active site1261Proton donor By similarity HAMAP MF_00333
Binding site1121Substrate By similarity HAMAP MF_00333
Site1951Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
Q1QIG6 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 27EED9D16A20B15C

FASTA29533,222
        10         20         30         40         50         60 
MEAASYDDHK TRARAWFEQL RDDICAAFEK LEDDAPASLY PGSAGRFVRT PWERTDHTGQ 

        70         80         90        100        110        120 
PGGGGVMSMM HGRLFEKVGV HCSTVHGEFA PEFRAQIPGA EADPKFWASG ISLIAHMRNP 

       130        140        150        160        170        180 
HIPAVHMNTR FVVTTKAWFG GGGDLTPVLM RRRTQEDADS VAFHAAMKSA CDAHAAIADY 

       190        200        210        220        230        240 
DKYKTWCDEY FHLPHRNEAR GIGGIFYDWH DSGDWDADLA FTQDVGRALL KVYPELVRRN 

       250        260        270        280        290 
FNTPWTAADR EEQLIRRGRY AEFNLLYDRG TIFGLKTGGN VESILSSMPP EVKWP

« Hide

References

[1]"Complete sequence of chromosome of Nitrobacter hamburgensis X14."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X14 / DSM 10229.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000319 Genomic DNA. Translation: ABE63981.1.
RefSeqYP_578441.1. NC_007964.1.

3D structure databases

ProteinModelPortalQ1QIG6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1QIG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4031908.
GenomeReviewsGene locus Nham_3246 in contig CP000319_GR.
KEGGnha:Nham_3246.
NMPDRfig|323097.3.peg.2811.
PATRIC22694475. VBINitHam61822_4237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
PhylomeDBQ1QIG6.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1QIG6_NITHX
AccessionPrimary (citable) accession number: Q1QIG6
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info