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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei197UniRule annotation1
Active sitei225UniRule annotation1
Active sitei321UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Nham_3373
OrganismiNitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000001953 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642971 – 381Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei714-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_3373.

Structurei

3D structure databases

ProteinModelPortaliQ1QI44.
SMRiQ1QI44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 138Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini183 – 379CheB-type methylesteraseUniRule annotationAdd BLAST197

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QI44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTAVASPAA LDSGRQEPLR VMVVDDSVVI RGLISRWIEA EPDMVVAASL
60 70 80 90 100
RTGLDAVNQV ERANPDVVVL DIEMPELDGI SALPQLLAKK RNLIVIMAST
110 120 130 140 150
LTRRNAEISF KALSLGAADY IPKPESTREI AAADIFKHDL IQKIRHLAAK
160 170 180 190 200
RRRPAALASA REPEPRPIQA TPVPAHSAPV LRPFSTHAPR ALLIGSSTGG
210 220 230 240 250
PQALMTLVAG IGPVIDRYPV LITQHMPPTF TTILAEHLAR AAGRPAHEGV
260 270 280 290 300
DEEIVKPGHI YLATGGRHMR LARKGTGAVI VLDDGPAVNF CKPAVDPLFT
310 320 330 340 350
SAIDVWQGGI LAVILTGMGS DGMRGGQQIV AAGGNVIAQD EASSVVWGMP
360 370 380
GAAAQAGICA AVLPLQQIAP KLVRLFAGDH S
Length:381
Mass (Da):40,227
Last modified:May 16, 2006 - v1
Checksum:i119B822F617DC282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE64103.1.
RefSeqiWP_011511756.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE64103; ABE64103; Nham_3373.
KEGGinha:Nham_3373.

Similar proteinsi

Entry informationi

Entry nameiCHEB_NITHX
AccessioniPrimary (citable) accession number: Q1QI44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome