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Q1QI14

- PNCB_NITHX

UniProt

Q1QI14 - PNCB_NITHX

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-3457-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Nham_3403
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146845Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_3403.

Structurei

3D structure databases

ProteinModelPortaliQ1QI14.
SMRiQ1QI14. Positions 1-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QI14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVTDIATRT YNHGWRLDPI VRSLLDTDFY KLLMLQMIRE FYPNEHVTFS
60 70 80 90 100
VINRSRHVRL AEAIDEGELR AQLDHARSIR FSKNELIWLA GNTFYGKTQM
110 120 130 140 150
FSPDFIDWLA TFRLGEYELR KVDGQYELHF HGPWTHTTMW EIPALAILNE
160 170 180 190 200
LRSRQVTKGQ GRFALDVLYA RAKAKLWAKV ERLRKLDDLW LSDFGTRRRH
210 220 230 240 250
GFLWQRWCVE AAKEGLGPAF TGTSNVLLAM DNDLEAIGTN AHELPMVAAA
260 270 280 290 300
LADDDTALRR APYRILDQWR HTYGGNLLVA LPDAFGTQAF LRDAPEWVAD
310 320 330 340 350
WTGFRPDSLP PIAAGEEIIK WWKQKSRDPR EKLLVFSDGM DVDSIEETYH
360 370 380 390 400
HFAGRVRVSF GWGTNLTNDF VGCSPDGTVD LDPISIVCKV TSVNGRPAVK
410 420 430
LSDNPEKATG EPSEIERYLR VFGSAGRVRA PVHV
Length:434
Mass (Da):49,559
Last modified:May 16, 2006 - v1
Checksum:iFDBECF475836DB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE64133.1.
RefSeqiYP_578593.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE64133; ABE64133; Nham_3403.
GeneIDi4033226.
KEGGinha:Nham_3403.
PATRICi22694825. VBINitHam61822_4409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE64133.1 .
RefSeqi YP_578593.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QI14.
SMRi Q1QI14. Positions 1-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_3403.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE64133 ; ABE64133 ; Nham_3403 .
GeneIDi 4033226.
KEGGi nha:Nham_3403.
PATRICi 22694825. VBINitHam61822_4409.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci NHAM323097:GHP7-3457-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiPNCB_NITHX
AccessioniPrimary (citable) accession number: Q1QI14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3