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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Nham_3403
OrganismiNitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000001953 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001468451 – 434Nicotinate phosphoribosyltransferaseAdd BLAST434

Proteomic databases

PRIDEiQ1QI14

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_3403

Structurei

3D structure databases

ProteinModelPortaliQ1QI14
SMRiQ1QI14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284929
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QI14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTDIATRT YNHGWRLDPI VRSLLDTDFY KLLMLQMIRE FYPNEHVTFS
60 70 80 90 100
VINRSRHVRL AEAIDEGELR AQLDHARSIR FSKNELIWLA GNTFYGKTQM
110 120 130 140 150
FSPDFIDWLA TFRLGEYELR KVDGQYELHF HGPWTHTTMW EIPALAILNE
160 170 180 190 200
LRSRQVTKGQ GRFALDVLYA RAKAKLWAKV ERLRKLDDLW LSDFGTRRRH
210 220 230 240 250
GFLWQRWCVE AAKEGLGPAF TGTSNVLLAM DNDLEAIGTN AHELPMVAAA
260 270 280 290 300
LADDDTALRR APYRILDQWR HTYGGNLLVA LPDAFGTQAF LRDAPEWVAD
310 320 330 340 350
WTGFRPDSLP PIAAGEEIIK WWKQKSRDPR EKLLVFSDGM DVDSIEETYH
360 370 380 390 400
HFAGRVRVSF GWGTNLTNDF VGCSPDGTVD LDPISIVCKV TSVNGRPAVK
410 420 430
LSDNPEKATG EPSEIERYLR VFGSAGRVRA PVHV
Length:434
Mass (Da):49,559
Last modified:May 16, 2006 - v1
Checksum:iFDBECF475836DB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA Translation: ABE64133.1
RefSeqiWP_011511785.1, NC_007964.1

Genome annotation databases

EnsemblBacteriaiABE64133; ABE64133; Nham_3403
KEGGinha:Nham_3403

Similar proteinsi

Entry informationi

Entry nameiPNCB_NITHX
AccessioniPrimary (citable) accession number: Q1QI14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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