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Q1QHE6

- ASSY_NITHX

UniProt

Q1QHE6 - ASSY_NITHX

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Protein

Argininosuccinate synthase

Gene
argG, Nham_3623
Organism
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei121 – 1211ATP; via amide nitrogen By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei182 – 1821Citrulline By similarity
Binding sitei191 – 1911Citrulline By similarity
Binding sitei267 – 2671Citrulline By similarity
Binding sitei279 – 2791Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-3680-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Nham_3623
OrganismiNitrobacter hamburgensis (strain X14 / DSM 10229)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
ProteomesiUP000001953: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Argininosuccinate synthaseUniRule annotationPRO_0000263942Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi323097.Nham_3623.

Structurei

3D structure databases

ProteinModelPortaliQ1QHE6.
SMRiQ1QHE6. Positions 7-398.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiGIKSKFD.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QHE6-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKVEKVVL AYSGGLDTSI ILKWLQTTYG AEVVTFTADL GQGEELEPAR    50
QKALLLGIKP ENIFIEDLRE EFVRDYVFPM FRANAVYEGQ YLLGTSIARP 100
LIAKKQIEIA EKVGADAVSH GATGKGNDQV RFELGYYALK PDITIIAPWR 150
EWDFKSREKL IAFAEQHQIP IAKDKRGEAP FSVDANLLHA SSEGKVLEDP 200
AQEVPDYVYS RTIDPQAAPD QPTYITIDFE KGDAVAIDGR TMSPATLLAK 250
LNELGRANGI GRLDLVENRF VGMKSRGMYE TPGGTILLVA HRGIEQITLD 300
RGAAHLKDEL MPKYAELIYN GFWFAPEREM LQAAIDHSQQ YVSGQVRLKL 350
YKGNVILVGR DSRYSLYDQD LVTFEEGAVA YDHRDAAGFI KLNALRLRTL 400
GQRKKKLGL 409
Length:409
Mass (Da):45,711
Last modified:May 16, 2006 - v1
Checksum:i43471AAB3B560DE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE64351.1.
RefSeqiWP_011511992.1. NC_007964.1.
YP_578811.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE64351; ABE64351; Nham_3623.
GeneIDi4030393.
KEGGinha:Nham_3623.
PATRICi22695317. VBINitHam61822_4652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000319 Genomic DNA. Translation: ABE64351.1 .
RefSeqi WP_011511992.1. NC_007964.1.
YP_578811.1. NC_007964.1.

3D structure databases

ProteinModelPortali Q1QHE6.
SMRi Q1QHE6. Positions 7-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323097.Nham_3623.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE64351 ; ABE64351 ; Nham_3623 .
GeneIDi 4030393.
KEGGi nha:Nham_3623.
PATRICi 22695317. VBINitHam61822_4652.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi GIKSKFD.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci NHAM323097:GHP7-3680-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X14 / DSM 10229.

Entry informationi

Entry nameiASSY_NITHX
AccessioniPrimary (citable) accession number: Q1QHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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