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Protein

Homoserine kinase

Gene

thrB

Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Nham_2309)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNHAM323097:GHP7-3805-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Nham_3744
OrganismiNitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000001953 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Homoserine kinasePRO_0000300795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_3744.

Structurei

3D structure databases

ProteinModelPortaliQ1QH29.
SMRiQ1QH29. Positions 5-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUV. Bacteria.
COG2334. LUCA.
HOGENOMiHOG000004810.
KOiK02204.
OMAiAGALRFW.
OrthoDBiPOG091H0G0T.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2. 1 hit.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QH29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYTDVAAD ELADFLKAYD IGELLSYKGI AEGVENSNYL LHTTAGSFFL
60 70 80 90 100
TLYEKRVAVD DLPFFLGLMG HLATHGIVCP QPVKARNGEA LGCLAGRPAA
110 120 130 140 150
IIDFLEGVWP RKPNVTHCAA VGAALAKLHL AGRDFPMRRA NALSVSSWRP
160 170 180 190 200
LFEQATPCID TVQHGLHDFL KAELDHLERH WPQNLPAGVI HADLFPDNVL
210 220 230 240 250
FLGDRLSGLI DFYFACNDFF AYDVAICLNA WCFEPDHSFN VTKARALLGA
260 270 280 290 300
YNRERALSEA EQAALPLLAR GAALRFLLTR LVDFLNVPAG ALVKPKDPLE
310 320
YVRKLRFQQS VGNIREYGVA ASGLVA
Length:326
Mass (Da):35,835
Last modified:May 16, 2006 - v1
Checksum:i52D06D04A26999EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE64468.1.
RefSeqiWP_011512105.1. NC_007964.1.

Genome annotation databases

EnsemblBacteriaiABE64468; ABE64468; Nham_3744.
KEGGinha:Nham_3744.
PATRICi22695585. VBINitHam61822_4785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA. Translation: ABE64468.1.
RefSeqiWP_011512105.1. NC_007964.1.

3D structure databases

ProteinModelPortaliQ1QH29.
SMRiQ1QH29. Positions 5-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323097.Nham_3744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE64468; ABE64468; Nham_3744.
KEGGinha:Nham_3744.
PATRICi22695585. VBINitHam61822_4785.

Phylogenomic databases

eggNOGiENOG4105CUV. Bacteria.
COG2334. LUCA.
HOGENOMiHOG000004810.
KOiK02204.
OMAiAGALRFW.
OrthoDBiPOG091H0G0T.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciNHAM323097:GHP7-3805-MONOMER.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2. 1 hit.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKHSE_NITHX
AccessioniPrimary (citable) accession number: Q1QH29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.