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Protein

Homoserine kinase

Gene

thrB

Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Nham_0472)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Nham_2309)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Nham_3744
OrganismiNitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Taxonomic identifieri323097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeNitrobacter
Proteomesi
  • UP000001953 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003007951 – 326Homoserine kinaseAdd BLAST326

Proteomic databases

PRIDEiQ1QH29

Interactioni

Protein-protein interaction databases

STRINGi323097.Nham_3744

Structurei

3D structure databases

ProteinModelPortaliQ1QH29
SMRiQ1QH29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUV Bacteria
COG2334 LUCA
HOGENOMiHOG000004810
KOiK02204
OMAiAGALRFW
OrthoDBiPOG091H0G0T

Family and domain databases

CDDicd05153 HomoserineK_II, 1 hit
HAMAPiMF_00301 Homoser_kinase_2, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR005280 Homoserine_kinase_II
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR00938 thrB_alt, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QH29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYTDVAAD ELADFLKAYD IGELLSYKGI AEGVENSNYL LHTTAGSFFL
60 70 80 90 100
TLYEKRVAVD DLPFFLGLMG HLATHGIVCP QPVKARNGEA LGCLAGRPAA
110 120 130 140 150
IIDFLEGVWP RKPNVTHCAA VGAALAKLHL AGRDFPMRRA NALSVSSWRP
160 170 180 190 200
LFEQATPCID TVQHGLHDFL KAELDHLERH WPQNLPAGVI HADLFPDNVL
210 220 230 240 250
FLGDRLSGLI DFYFACNDFF AYDVAICLNA WCFEPDHSFN VTKARALLGA
260 270 280 290 300
YNRERALSEA EQAALPLLAR GAALRFLLTR LVDFLNVPAG ALVKPKDPLE
310 320
YVRKLRFQQS VGNIREYGVA ASGLVA
Length:326
Mass (Da):35,835
Last modified:May 16, 2006 - v1
Checksum:i52D06D04A26999EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000319 Genomic DNA Translation: ABE64468.1
RefSeqiWP_011512105.1, NC_007964.1

Genome annotation databases

EnsemblBacteriaiABE64468; ABE64468; Nham_3744
KEGGinha:Nham_3744

Similar proteinsi

Entry informationi

Entry nameiKHSE_NITHX
AccessioniPrimary (citable) accession number: Q1QH29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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