Reviewed, UniProtKB/Swiss-Prot Q1QH19 (F16A1_NITHX)

Names and origin

Protein names

Recommended name:
    Fructose-1,6-bisphosphatase class 1 1
      Short name=FBPase class 1 1
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1

Gene names

Name:	fbp1
Ordered Locus Names:	Nham_3754

Organism

Nitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

323097 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Fructose-1,6-bisphosphatase class 1 1 HAMAP MF_01855		PRO_0000364612
Regions
	Region	112 – 115	4	Substrate binding By similarity
Sites
	Metal binding	90	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 2 By similarity
	Metal binding	111	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	112	1	Magnesium 2 By similarity
	Metal binding	272	1	Magnesium 2 By similarity
	Binding site	200	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QH19-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: E64B35EADBD82164	FASTA	345	36,942
	10 20 30 40 50 60 MSRELTLQER LDGEAGPDPL RQAVKKAVAA LAQAAIDISD LTCRGALAGI TGEAQGRNTD 70 80 90 100 110 120 GDVQKDLDVR ADQIIRDALG ALPIAVLASE EMAELDILNP GAPISVAFDP LDGSSNINTN 130 140 150 160 170 180 ISVGTIFSIM PTPPDASAAF TQPGSAQLAA GFVVYGPQTS LILTLGQGVD IFTLDRVERV 190 200 210 220 230 240 FKLTGSMMQI PADATEFAIN TSNRRHWDLP VRAYIDECLM GADGPSGKNF NMRWIGSLVA 250 260 270 280 290 300 EAFRILVRGG IFLYPGDARD GYEDGRLRLV YEAHPMAFII EQAGGGASTG RKRILDIVPG 310 320 330 340 SLHQRVPLIM GSIKNVRRLE DMHTGPNVAL EANAPLFGHR GLFRV

References

[1]

"Complete sequence of chromosome of Nitrobacter hamburgensis X14." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000319 Genomic DNA. Translation: ABE64478.1.
RefSeq	YP_578938.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QH19.
Genome annotation databases
GeneID	4032491.
GenomeReviews	Gene locus Nham_3754 in contig CP000319_GR.
KEGG	nha:Nham_3754.
NMPDR	fig|323097.3.peg.2362.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QH19.
OMA	LFGQRGL.
Enzyme and pathway databases
BioCyc	NHAM323097:NHAM_3754-MON.
Family and domain databases
HAMAP	MF_01855. [Tree]
InterPro	IPR000146. Fructose_bisphosphatase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PRINTS	PR00115. F16BPHPHTASE.
ProDom	PD001491. In_FB_phphtase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16A1_NITHX

Accession

Primary (citable) accession number: Q1QH19

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)