Q1QGD7 (F16A2_NITHX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1 2
Short name=FBPase class 1 2
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2

Gene names

Name:	fbp2
Ordered Locus Names:	Nham_4046

Encoded on

Plasmid pNITHX1

Organism

Nitrobacter hamburgensis (strain X14 / DSM 10229) [Complete proteome] [HAMAP]

Taxonomic identifier

323097 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Nitrobacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Fructose-1,6-bisphosphatase class 1 2 HAMAP MF_01855		PRO_0000364613
Regions
	Region	112 – 115	4	Substrate binding By similarity
Sites
	Metal binding	90	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 2 By similarity
	Metal binding	111	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	112	1	Magnesium 2 By similarity
	Metal binding	272	1	Magnesium 2 By similarity
	Binding site	200	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QGD7 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 64CFD460FA21FD5A	FASTA	345	37,031
	10 20 30 40 50 60 MSHELTLQQR LEVQAGPDPL HRAVKEAVAA LAQAAIDISD LTCRGALAGI TGEAQGRNTD 70 80 90 100 110 120 GDIQKDLDVR ADQIIRDALS ALPIAVLASE EMAELDILNP GAPISVAFDP LDGSSNINTN 130 140 150 160 170 180 ISVGTIFSIM PTPPDASAAF TQPGSAQLAA GFVVYGPQTS LILTLGQGVD IFTLDRVERV 190 200 210 220 230 240 FKLTGSMMQI PADATEFAIN TSNRRHWDLP VRAYIDECLM GADGPSGKNF NMRWIGSLVA 250 260 270 280 290 300 EAFRILVRGG IFLYPGDARD GYEDGRLRLV YEAHPMAFII EQAGGGASTG RKRILDIVPG 310 320 330 340 SLHQRVPLIM GSIKNVRRLE DMHTGPNVAL EANAPLFGHR GLFRV

References

[1]

"Complete sequence of plasmid 1 of Nitrobacter hamburgensis X14." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X14 / DSM 10229.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000320 Genomic DNA. Translation: ABE64710.1.
RefSeq	YP_571542.1. NC_007959.1.
3D structure databases
ProteinModelPortal	Q1QGD7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QGD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4025399.
GenomeReviews	Gene locus Nham_4046 in contig CP000320_GR.
KEGG	nha:Nham_4046.
NMPDR	fig|323097.3.peg.4091.
PATRIC	22685925. VBINitHam61822_0009.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0158.
HOGENOM	HBG731261.
OMA	ANEVDTC.
PhylomeDB	Q1QGD7.
ProtClustDB	PRK09293.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16A2_NITHX

Accession

Primary (citable) accession number: Q1QGD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program