Q1QEB6 (ACSA_PSYCK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	Pcryo_0203

Organism

Psychrobacter cryohalolentis (strain K5) [Complete proteome] [HAMAP]

Taxonomic identifier

335284 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	655 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 655	655	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000137273
Sites
	Active site	519	1	By similarity
Amino acid modifications
	Modified residue	611	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QEB6 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: F6620974A5B533E3	FASTA	655	72,313
	10 20 30 40 50 60 MTQKSFPIAP EFLAAANITA EQYAEQYKQS IASPEATDAF WAERAELIDW IKKPTKISDV 70 80 90 100 110 120 SYDLEDFRIK WFEDGELNIS VNCLDRHVRN NPYKPAIIWE GDHPSLHKII SFKELHEAVC 130 140 150 160 170 180 RLGNAMRKLG VKKGDRVTLY MPMIPEAMVA MLACTRIGAV HSVVFGGFSA ESLGNRIIDS 190 200 210 220 230 240 QSKLVITADE GIRGNKRTPL KANVDRALDM DGTDSVSNVI VVHRTGNSVP MSGRRDIWYH 250 260 270 280 290 300 SLVDGESQHC EPEVMNAEDP LFLLYTSGST GKPKGVLHTT GGYITYALST FRDVFDIKED 310 320 330 340 350 360 DVYWCTADVG WVTGHTYATY APLANGTTTV MFEGVPEYPT WARIGHIIDK HQITVLYTAP 370 380 390 400 410 420 TAIRAMMKEG DTFVRESDRS SLRLLGTVGE PINPEAWDWY YHVVGGSKCP VVDTWWQTET 430 440 450 460 470 480 GGIMLAPIPG TVAMKPGAAM NPLYGIVPEV IDTDGVALEG AAEGNLVINS SWPGQMRTIY 490 500 510 520 530 540 QDHARFLTTY FTEYPGYYFT GDGVQRDEDG HYWITGRVDD VLNVSGHRLG TAEIESSIVA 550 560 570 580 590 600 HPATAEAAVV GMPHDIRGMG ICAFVILKSS ETATESLKSE LNRHVRSEIG PIANLDAIYM 610 620 630 640 650 VNVLPKTRSG KIMRRILRSL AAGQYVGLGD LSTLADSSVI NELVEVVKTE RAKSH

References

[1]

"Complete sequence of chromosome of Psychrobacter cryohalolentis K5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000323 Genomic DNA. Translation: ABE73987.1.
RefSeq	YP_579471.1. NC_007969.1.
3D structure databases
ProteinModelPortal	Q1QEB6.
SMR	Q1QEB6. Positions 7-648.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QEB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4035683.
GenomeReviews	Gene locus Pcryo_0203 in contig CP000323_GR.
KEGG	pcr:Pcryo_0203.
NMPDR	fig|335284.3.peg.812.
PATRIC	23059821. VBIPsyCry128170_0258.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	RKIAAND.
PhylomeDB	Q1QEB6.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	PCRY335284:PCRYO_0203-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_PSYCK

Accession

Primary (citable) accession number: Q1QEB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program