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Protein

Adenine deaminase

Gene

Pcryo_0456

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14Zinc; catalyticUniRule annotation1
Metal bindingi16Zinc; catalyticUniRule annotation1
Metal bindingi194Zinc; catalyticUniRule annotation1
Active sitei197Proton donorUniRule annotation1
Sitei218Important for catalytic activityUniRule annotation1
Metal bindingi275Zinc; catalyticUniRule annotation1
Binding sitei276SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-471-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:Pcryo_0456
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000002425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000176861 – 332Adenine deaminaseAdd BLAST332

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_0456

Structurei

3D structure databases

ProteinModelPortaliQ1QDL4
SMRiQ1QDL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EKD Bacteria
COG1816 LUCA
HOGENOMiHOG000218813
KOiK21053
OMAiRGWFRFQ
OrthoDBiPOG091H02QG

Family and domain databases

CDDicd01320 ADA, 1 hit
HAMAPiMF_01962 Adenine_deaminase, 1 hit
InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR028892 ADE
IPR006330 Ado/ade_deaminase
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01430 aden_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QDL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLIKRLPK AELHLHIEGS LEPELMFRLA KKNQIEIPYK DIEDVRNAYN
60 70 80 90 100
FTNLQTFLDI YYAGANVLIT QDDFYDLTWE YILKCVEDNV IHTEIFFDPQ
110 120 130 140 150
THTARGVTFE TVITGIKRAL ADAKAQYGIT SCIIMCFLRH LSQEEAFETL
160 170 180 190 200
EQALPFKDDI IGVGLDSSEL GNPPSKFIEV FKKAKEEGFK LVAHAGEEAD
210 220 230 240 250
FSYIYEALDL LDISRIDHGV QSIKSAELMQ RLKDEQMPLT VCPNSNIELR
260 270 280 290 300
VFNNYKEHNI KELLDYGLNI TVNSDDPAYF KGYINQNFIN ISENLPLTED
310 320 330
DIITLVKNSF RSSFISDELK QQYLNRVDQA VG
Length:332
Mass (Da):38,112
Last modified:May 16, 2006 - v1
Checksum:i00D5DC75978CF913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA Translation: ABE74239.1
RefSeqiWP_011512824.1, NC_007969.1

Genome annotation databases

EnsemblBacteriaiABE74239; ABE74239; Pcryo_0456
KEGGipcr:Pcryo_0456

Similar proteinsi

Entry informationi

Entry nameiADE_PSYCK
AccessioniPrimary (citable) accession number: Q1QDL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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