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Q1QDE6

- ILVC_PSYCK

UniProt

Q1QDE6 - ILVC_PSYCK

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, Pcryo_0524
Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071 Reviewed prediction

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-541-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:Pcryo_0524
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000002425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Ketol-acid reductoisomeraseUniRule annotation
PRO_0000252774Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_0524.

Structurei

3D structure databases

ProteinModelPortaliQ1QDE6.
SMRiQ1QDE6. Positions 1-327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
KOiK00053.
OMAiRFAKDFI.
OrthoDBiEOG625K07.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QDE6-1 [UniParc]FASTAAdd to Basket

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MNVYYDKDCD LSIVQGKKVA IIGYGSQGHA HALNLQDSNV DVTVGLRANS    50
GSWKKAENAG LKVAEVEEAV KAADIIMILT PDEFQKELYN DVIEPNIKQG 100
ATLAFAHGFA IHYNQVIPRS DLDVIMVAPK APGHTVRSEF AKGGGIPDLI 150
AIYQDASGQA KQLALSYAAG VGGGRSGIIE TTFKDETETD LFGEQAVLCG 200
GAVELVKMGF ETLTEAGYAP EMAYFECLHE LKLIVDLMYE GGIADMNYSI 250
SNNAEYGEYV TGPEVINEQS REAMRNALKR IQSGEYAKMF ISEGATNYPS 300
MTARRRNNAE HQIEITGAKL RGMMPWIGGN KIIDKDKN 338
Length:338
Mass (Da):36,799
Last modified:May 16, 2006 - v1
Checksum:i5EAA1C2215AD99C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000323 Genomic DNA. Translation: ABE74307.1.
RefSeqiYP_579791.1. NC_007969.1.

Genome annotation databases

EnsemblBacteriaiABE74307; ABE74307; Pcryo_0524.
GeneIDi4035867.
KEGGipcr:Pcryo_0524.
PATRICi23060511. VBIPsyCry128170_0593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000323 Genomic DNA. Translation: ABE74307.1 .
RefSeqi YP_579791.1. NC_007969.1.

3D structure databases

ProteinModelPortali Q1QDE6.
SMRi Q1QDE6. Positions 1-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335284.Pcryo_0524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE74307 ; ABE74307 ; Pcryo_0524 .
GeneIDi 4035867.
KEGGi pcr:Pcryo_0524.
PATRICi 23060511. VBIPsyCry128170_0593.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
KOi K00053.
OMAi RFAKDFI.
OrthoDBi EOG625K07.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .
BioCyci PCRY335284:GHE9-541-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K5.

Entry informationi

Entry nameiILVC_PSYCK
AccessioniPrimary (citable) accession number: Q1QDE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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