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Q1QDE6 (ILVC_PSYCK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:Pcryo_0524
OrganismPsychrobacter cryohalolentis (strain K5) [Complete proteome] [HAMAP]
Taxonomic identifier335284 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_0000252774

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
Q1QDE6 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 5EAA1C2215AD99C6

FASTA33836,799
        10         20         30         40         50         60 
MNVYYDKDCD LSIVQGKKVA IIGYGSQGHA HALNLQDSNV DVTVGLRANS GSWKKAENAG 

        70         80         90        100        110        120 
LKVAEVEEAV KAADIIMILT PDEFQKELYN DVIEPNIKQG ATLAFAHGFA IHYNQVIPRS 

       130        140        150        160        170        180 
DLDVIMVAPK APGHTVRSEF AKGGGIPDLI AIYQDASGQA KQLALSYAAG VGGGRSGIIE 

       190        200        210        220        230        240 
TTFKDETETD LFGEQAVLCG GAVELVKMGF ETLTEAGYAP EMAYFECLHE LKLIVDLMYE 

       250        260        270        280        290        300 
GGIADMNYSI SNNAEYGEYV TGPEVINEQS REAMRNALKR IQSGEYAKMF ISEGATNYPS 

       310        320        330 
MTARRRNNAE HQIEITGAKL RGMMPWIGGN KIIDKDKN 

« Hide

References

[1]"Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000323 Genomic DNA. Translation: ABE74307.1.
RefSeqYP_579791.1. NC_007969.1.

3D structure databases

ProteinModelPortalQ1QDE6.
SMRQ1QDE6. Positions 1-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335284.Pcryo_0524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE74307; ABE74307; Pcryo_0524.
GeneID4035867.
KEGGpcr:Pcryo_0524.
PATRIC23060511. VBIPsyCry128170_0593.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAKQRWSVS.
OrthoDBEOG625K07.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycPCRY335284:GHE9-541-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_PSYCK
AccessionPrimary (citable) accession number: Q1QDE6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways