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Q1QDA4

- SYL_PSYCK

UniProt

Q1QDA4 - SYL_PSYCK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei673 – 6731ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pcryo_0566
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000002425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Leucine--tRNA ligasePRO_0000334798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_0566.

Structurei

3D structure databases

ProteinModelPortaliQ1QDA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 9311"HIGH" regionAdd
BLAST
Motifi670 – 6745"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QDA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWHYKISPH LSVITDSEPT MTNAVTAETA NTNHTNNASS DKTQYQPQLI
60 70 80 90 100
EAQQQAKWAT DKRFEVSNEP SDKPSRYMLS MFPYPSGKLH MGHVRNYTIS
110 120 130 140 150
DVLSRYYRLK GYEVMQPMGW DGFGLPAENA AIANQTPPAK WTFENIDSMR
160 170 180 190 200
AQLKLLGLSI DWSREFATCS PEYYQWEQWL FLQLYKKGLV YKKLATVNWD
210 220 230 240 250
PVDNTVLANE QVIDGKGWRS GAMVEKRDIP MYYFNITDYA DELLDDLDQL
260 270 280 290 300
EGHWPSEVIT MQRNWIGRSS GMEVHFPYEL AGQSNSLDVF TTRPDTLMGV
310 320 330 340 350
TYVAVAAEHP LAQYASENNK AIADFCALCK KGSVAEADLA KAEKIGMDTG
360 370 380 390 400
LTVTHPLTGE EVPVWVANYV LMSYGSGAVM AVPAHDERDY EFATKYNLPI
410 420 430 440 450
KQVIDIPAGY FDDVEEGNEN CAYTERNTLV NSGEFDGMDF EQAFEAMLAK
460 470 480 490 500
LEPQELAKKK IQYRLRDWGV SRQRYWGCPI PMVNCEHCGT VPVEEQDLPV
510 520 530 540 550
VLPTDVVPDG RGNPLKNIPE FVNTTCPKCG NPAERETDTF DTFVESSWYY
560 570 580 590 600
ARFASPHDTT NMVNKSAANK WLPVDQYIGG VEHAVMHLLY ARFFHKLMRD
610 620 630 640 650
ENLVSGDEPF ANLMTQGMVL AGTFYRVNAD GSTTYYFTKD IDIDFNERGQ
660 670 680 690 700
PIKAILKSDG QPVTIGKIEK MSKSKNNGVD PQITIDKYGA DTVRLYTLFT
710 720 730 740 750
APADQTLEWS DDALKGPYNF VKKVWRIASE HIQALTDANL SLESLNSDAL
760 770 780 790 800
NTDSLSKEAK ALRRKTHETI GKIDSDLGKR LALNTPVSSL MELANELSNF
810 820 830 840 850
KASSEQELQV QHEALTDLLI MLSVYAPHIG EYLLEQLGLD TVTLNYPMVD
860 870 880 890 900
ESALVQDMIT MVIQVNGKMR GKMDVAPNSD PEQLKAQARA IEGVAKFLTG
910
EIKKEIVVPN KLVNIVVAG
Length:919
Mass (Da):103,257
Last modified:May 20, 2008 - v2
Checksum:i892790991B9E9351
GO

Sequence cautioni

The sequence ABE74349.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE74349.1. Different initiation.
RefSeqiYP_579833.1. NC_007969.1.

Genome annotation databases

EnsemblBacteriaiABE74349; ABE74349; Pcryo_0566.
GeneIDi4033584.
KEGGipcr:Pcryo_0566.
PATRICi23060609. VBIPsyCry128170_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE74349.1 . Different initiation.
RefSeqi YP_579833.1. NC_007969.1.

3D structure databases

ProteinModelPortali Q1QDA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335284.Pcryo_0566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE74349 ; ABE74349 ; Pcryo_0566 .
GeneIDi 4033584.
KEGGi pcr:Pcryo_0566.
PATRICi 23060609. VBIPsyCry128170_0635.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PCRY335284:GHE9-590-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K5.

Entry informationi

Entry nameiSYL_PSYCK
AccessioniPrimary (citable) accession number: Q1QDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3