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Q1QDA4

- SYL_PSYCK

UniProt

Q1QDA4 - SYL_PSYCK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei673 – 6731ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPCRY335284:GHE9-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pcryo_0566
    OrganismiPsychrobacter cryohalolentis (strain K5)
    Taxonomic identifieri335284 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000002425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Leucine--tRNA ligasePRO_0000334798Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi335284.Pcryo_0566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QDA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi83 – 9311"HIGH" regionAdd
    BLAST
    Motifi670 – 6745"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QDA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWHYKISPH LSVITDSEPT MTNAVTAETA NTNHTNNASS DKTQYQPQLI    50
    EAQQQAKWAT DKRFEVSNEP SDKPSRYMLS MFPYPSGKLH MGHVRNYTIS 100
    DVLSRYYRLK GYEVMQPMGW DGFGLPAENA AIANQTPPAK WTFENIDSMR 150
    AQLKLLGLSI DWSREFATCS PEYYQWEQWL FLQLYKKGLV YKKLATVNWD 200
    PVDNTVLANE QVIDGKGWRS GAMVEKRDIP MYYFNITDYA DELLDDLDQL 250
    EGHWPSEVIT MQRNWIGRSS GMEVHFPYEL AGQSNSLDVF TTRPDTLMGV 300
    TYVAVAAEHP LAQYASENNK AIADFCALCK KGSVAEADLA KAEKIGMDTG 350
    LTVTHPLTGE EVPVWVANYV LMSYGSGAVM AVPAHDERDY EFATKYNLPI 400
    KQVIDIPAGY FDDVEEGNEN CAYTERNTLV NSGEFDGMDF EQAFEAMLAK 450
    LEPQELAKKK IQYRLRDWGV SRQRYWGCPI PMVNCEHCGT VPVEEQDLPV 500
    VLPTDVVPDG RGNPLKNIPE FVNTTCPKCG NPAERETDTF DTFVESSWYY 550
    ARFASPHDTT NMVNKSAANK WLPVDQYIGG VEHAVMHLLY ARFFHKLMRD 600
    ENLVSGDEPF ANLMTQGMVL AGTFYRVNAD GSTTYYFTKD IDIDFNERGQ 650
    PIKAILKSDG QPVTIGKIEK MSKSKNNGVD PQITIDKYGA DTVRLYTLFT 700
    APADQTLEWS DDALKGPYNF VKKVWRIASE HIQALTDANL SLESLNSDAL 750
    NTDSLSKEAK ALRRKTHETI GKIDSDLGKR LALNTPVSSL MELANELSNF 800
    KASSEQELQV QHEALTDLLI MLSVYAPHIG EYLLEQLGLD TVTLNYPMVD 850
    ESALVQDMIT MVIQVNGKMR GKMDVAPNSD PEQLKAQARA IEGVAKFLTG 900
    EIKKEIVVPN KLVNIVVAG 919
    Length:919
    Mass (Da):103,257
    Last modified:May 20, 2008 - v2
    Checksum:i892790991B9E9351
    GO

    Sequence cautioni

    The sequence ABE74349.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000323 Genomic DNA. Translation: ABE74349.1. Different initiation.
    RefSeqiYP_579833.1. NC_007969.1.

    Genome annotation databases

    EnsemblBacteriaiABE74349; ABE74349; Pcryo_0566.
    GeneIDi4033584.
    KEGGipcr:Pcryo_0566.
    PATRICi23060609. VBIPsyCry128170_0635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000323 Genomic DNA. Translation: ABE74349.1 . Different initiation.
    RefSeqi YP_579833.1. NC_007969.1.

    3D structure databases

    ProteinModelPortali Q1QDA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335284.Pcryo_0566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE74349 ; ABE74349 ; Pcryo_0566 .
    GeneIDi 4033584.
    KEGGi pcr:Pcryo_0566.
    PATRICi 23060609. VBIPsyCry128170_0635.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PCRY335284:GHE9-590-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K5.

    Entry informationi

    Entry nameiSYL_PSYCK
    AccessioniPrimary (citable) accession number: Q1QDA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3