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Q1QDA4

- SYL_PSYCK

UniProt

Q1QDA4 - SYL_PSYCK

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Protein
Leucine--tRNA ligase
Gene
leuS, Pcryo_0566
Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei673 – 6731ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pcryo_0566
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000002425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Leucine--tRNA ligaseUniRule annotation
PRO_0000334798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_0566.

Structurei

3D structure databases

ProteinModelPortaliQ1QDA4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 9311"HIGH" regionUniRule annotation
Add
BLAST
Motifi670 – 6745"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QDA4-1 [UniParc]FASTAAdd to Basket

« Hide

MLWHYKISPH LSVITDSEPT MTNAVTAETA NTNHTNNASS DKTQYQPQLI    50
EAQQQAKWAT DKRFEVSNEP SDKPSRYMLS MFPYPSGKLH MGHVRNYTIS 100
DVLSRYYRLK GYEVMQPMGW DGFGLPAENA AIANQTPPAK WTFENIDSMR 150
AQLKLLGLSI DWSREFATCS PEYYQWEQWL FLQLYKKGLV YKKLATVNWD 200
PVDNTVLANE QVIDGKGWRS GAMVEKRDIP MYYFNITDYA DELLDDLDQL 250
EGHWPSEVIT MQRNWIGRSS GMEVHFPYEL AGQSNSLDVF TTRPDTLMGV 300
TYVAVAAEHP LAQYASENNK AIADFCALCK KGSVAEADLA KAEKIGMDTG 350
LTVTHPLTGE EVPVWVANYV LMSYGSGAVM AVPAHDERDY EFATKYNLPI 400
KQVIDIPAGY FDDVEEGNEN CAYTERNTLV NSGEFDGMDF EQAFEAMLAK 450
LEPQELAKKK IQYRLRDWGV SRQRYWGCPI PMVNCEHCGT VPVEEQDLPV 500
VLPTDVVPDG RGNPLKNIPE FVNTTCPKCG NPAERETDTF DTFVESSWYY 550
ARFASPHDTT NMVNKSAANK WLPVDQYIGG VEHAVMHLLY ARFFHKLMRD 600
ENLVSGDEPF ANLMTQGMVL AGTFYRVNAD GSTTYYFTKD IDIDFNERGQ 650
PIKAILKSDG QPVTIGKIEK MSKSKNNGVD PQITIDKYGA DTVRLYTLFT 700
APADQTLEWS DDALKGPYNF VKKVWRIASE HIQALTDANL SLESLNSDAL 750
NTDSLSKEAK ALRRKTHETI GKIDSDLGKR LALNTPVSSL MELANELSNF 800
KASSEQELQV QHEALTDLLI MLSVYAPHIG EYLLEQLGLD TVTLNYPMVD 850
ESALVQDMIT MVIQVNGKMR GKMDVAPNSD PEQLKAQARA IEGVAKFLTG 900
EIKKEIVVPN KLVNIVVAG 919
Length:919
Mass (Da):103,257
Last modified:May 20, 2008 - v2
Checksum:i892790991B9E9351
GO

Sequence cautioni

The sequence ABE74349.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000323 Genomic DNA. Translation: ABE74349.1. Different initiation.
RefSeqiYP_579833.1. NC_007969.1.

Genome annotation databases

EnsemblBacteriaiABE74349; ABE74349; Pcryo_0566.
GeneIDi4033584.
KEGGipcr:Pcryo_0566.
PATRICi23060609. VBIPsyCry128170_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000323 Genomic DNA. Translation: ABE74349.1 . Different initiation.
RefSeqi YP_579833.1. NC_007969.1.

3D structure databases

ProteinModelPortali Q1QDA4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 335284.Pcryo_0566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE74349 ; ABE74349 ; Pcryo_0566 .
GeneIDi 4033584.
KEGGi pcr:Pcryo_0566.
PATRICi 23060609. VBIPsyCry128170_0635.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PCRY335284:GHE9-590-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K5.

Entry informationi

Entry nameiSYL_PSYCK
AccessioniPrimary (citable) accession number: Q1QDA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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