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Q1QCL7 (GCSP_PSYCK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Pcryo_0803
OrganismPsychrobacter cryohalolentis (strain K5) [Complete proteome] [HAMAP]
Taxonomic identifier335284 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter

Protein attributes

Sequence length965 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 965965Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045596

Amino acid modifications

Modified residue7111N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QCL7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 02AA48F292B797E9

FASTA965105,692
        10         20         30         40         50         60 
MTISQNPALD TFEGLFNEAE FVYRHLGSND AKQADLLSAI GYSDMATFIN ETVPEPVRLH 

        70         80         90        100        110        120 
KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR MPAVIQRNVL ENPGWYTAYT 

       130        140        150        160        170        180 
PYQAEIAQGR LEALLNFQQV CIDLTGLELA GASLLDEATA AAEAMAMSKR VSKSKSMQFF 

       190        200        210        220        230        240 
VDDRVYPQTL DVINTRAKYF GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA 

       250        260        270        280        290        300 
VKKNKTYVSV VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR 

       310        320        330        340        350        360 
SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA GMYAVYHGPG 

       370        380        390        400        410        420 
GVKRIATRIH AFATAFADVI KNANDSNLNV LHDQFFDSVV VDCGSEKLAS QIFQNADNVG 

       430        440        450        460        470        480 
YNLWRLGETK LSVAFSETSD QKDFNVLTQL FVTKAHDLPE DARVSLDSAH LRTDAILSHP 

       490        500        510        520        530        540 
VFNSHHTEHE MLRYLKSLED KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA 

       550        560        570        580        590        600 
PRDQVTGYVA MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV 

       610        620        630        640        650        660 
CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSTRLG ALMITYPSTH 

       670        680        690        700        710        720 
GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV GADVLHMNLH KTFCIPHGGG 

       730        740        750        760        770        780 
GPGMGPIGMK AHLAPFMANH TLSPVHNAQK DCSAVSAAPY GSASILPISW MYIAMMGRDG 

       790        800        810        820        830        840 
LLKATELALL NANYVAAELK DHYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL 

       850        860        870        880        890        900 
MDYGFHSPTM SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEALKAKA GEDNWTLENN 

       910        920        930        940        950        960 
PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG DKNLMCSCPS 


IENYM 

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References

[1]"Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000323 Genomic DNA. Translation: ABE74586.1.
RefSeqYP_580070.1. NC_007969.1.

3D structure databases

ProteinModelPortalQ1QCL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335284.Pcryo_0803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE74586; ABE74586; Pcryo_0803.
GeneID4033748.
KEGGpcr:Pcryo_0803.
PATRIC23061091. VBIPsyCry128170_0873.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycPCRY335284:GHE9-830-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PSYCK
AccessionPrimary (citable) accession number: Q1QCL7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families