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Q1QCL7

- GCSP_PSYCK

UniProt

Q1QCL7 - GCSP_PSYCK

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPCRY335284:GHE9-830-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Pcryo_0803
    OrganismiPsychrobacter cryohalolentis (strain K5)
    Taxonomic identifieri335284 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
    ProteomesiUP000002425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 965965Glycine dehydrogenase (decarboxylating)PRO_1000045596Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi335284.Pcryo_0803.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QCL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1QCL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTISQNPALD TFEGLFNEAE FVYRHLGSND AKQADLLSAI GYSDMATFIN    50
    ETVPEPVRLH KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR 100
    MPAVIQRNVL ENPGWYTAYT PYQAEIAQGR LEALLNFQQV CIDLTGLELA 150
    GASLLDEATA AAEAMAMSKR VSKSKSMQFF VDDRVYPQTL DVINTRAKYF 200
    GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA VKKNKTYVSV 250
    VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR 300
    SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA 350
    GMYAVYHGPG GVKRIATRIH AFATAFADVI KNANDSNLNV LHDQFFDSVV 400
    VDCGSEKLAS QIFQNADNVG YNLWRLGETK LSVAFSETSD QKDFNVLTQL 450
    FVTKAHDLPE DARVSLDSAH LRTDAILSHP VFNSHHTEHE MLRYLKSLED 500
    KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA PRDQVTGYVA 550
    MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV 600
    CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSTRLG 650
    ALMITYPSTH GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV 700
    GADVLHMNLH KTFCIPHGGG GPGMGPIGMK AHLAPFMANH TLSPVHNAQK 750
    DCSAVSAAPY GSASILPISW MYIAMMGRDG LLKATELALL NANYVAAELK 800
    DHYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL MDYGFHSPTM 850
    SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEALKAKA GEDNWTLENN 900
    PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG 950
    DKNLMCSCPS IENYM 965
    Length:965
    Mass (Da):105,692
    Last modified:May 16, 2006 - v1
    Checksum:i02AA48F292B797E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000323 Genomic DNA. Translation: ABE74586.1.
    RefSeqiYP_580070.1. NC_007969.1.

    Genome annotation databases

    EnsemblBacteriaiABE74586; ABE74586; Pcryo_0803.
    GeneIDi4033748.
    KEGGipcr:Pcryo_0803.
    PATRICi23061091. VBIPsyCry128170_0873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000323 Genomic DNA. Translation: ABE74586.1 .
    RefSeqi YP_580070.1. NC_007969.1.

    3D structure databases

    ProteinModelPortali Q1QCL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335284.Pcryo_0803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE74586 ; ABE74586 ; Pcryo_0803 .
    GeneIDi 4033748.
    KEGGi pcr:Pcryo_0803.
    PATRICi 23061091. VBIPsyCry128170_0873.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PCRY335284:GHE9-830-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K5.

    Entry informationi

    Entry nameiGCSP_PSYCK
    AccessioniPrimary (citable) accession number: Q1QCL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3