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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Pcryo_0803
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
ProteomesiUP000002425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965Glycine dehydrogenase (decarboxylating)PRO_1000045596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi335284.Pcryo_0803.

Structurei

3D structure databases

ProteinModelPortaliQ1QCL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR000192. Aminotrans_V_dom.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1QCL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISQNPALD TFEGLFNEAE FVYRHLGSND AKQADLLSAI GYSDMATFIN
60 70 80 90 100
ETVPEPVRLH KELDLPVAMS EHAALAKLRT MADDITVNKS YIGQGYSPVR
110 120 130 140 150
MPAVIQRNVL ENPGWYTAYT PYQAEIAQGR LEALLNFQQV CIDLTGLELA
160 170 180 190 200
GASLLDEATA AAEAMAMSKR VSKSKSMQFF VDDRVYPQTL DVINTRAKYF
210 220 230 240 250
GWEVVVGDFE LAKSGDYFGA LFQYVGVEGD VKDLTDVIAA VKKNKTYVSV
260 270 280 290 300
VSDIMSLVLL KSPADMGADV ALGSTQRFGI PMGFGGPHAA YFAFSDKAKR
310 320 330 340 350
SAPGRIIGVS KDSQGNTALR MALQTREQHI RREKANSNIC TSQVLLANLA
360 370 380 390 400
GMYAVYHGPG GVKRIATRIH AFATAFADVI KNANDSNLNV LHDQFFDSVV
410 420 430 440 450
VDCGSEKLAS QIFQNADNVG YNLWRLGETK LSVAFSETSD QKDFNVLTQL
460 470 480 490 500
FVTKAHDLPE DARVSLDSAH LRTDAILSHP VFNSHHTEHE MLRYLKSLED
510 520 530 540 550
KDLAMNRSMI SLGSCTMKLN ATSEMLPITW PEFANVHPFA PRDQVTGYVA
560 570 580 590 600
MIDSLQEQLK AITGFDDVSM QPNSGASGEY AGLLAIRRYH ESLGETDRDV
610 620 630 640 650
CLIPMSAHGT NPATAMMMGM KVVVVKTDDN GNVDIDDLTA KSEEHSTRLG
660 670 680 690 700
ALMITYPSTH GVFEEGIRKI CDLIHKHGGQ VYMDGANMNA QVGMMQPADV
710 720 730 740 750
GADVLHMNLH KTFCIPHGGG GPGMGPIGMK AHLAPFMANH TLSPVHNAQK
760 770 780 790 800
DCSAVSAAPY GSASILPISW MYIAMMGRDG LLKATELALL NANYVAAELK
810 820 830 840 850
DHYPVLYTGK NGRVAHECII DIRPLKEETG ISESDIAKRL MDYGFHSPTM
860 870 880 890 900
SFPVAGTLMI EPTESESKEE LDRFISALKS IKAEALKAKA GEDNWTLENN
910 920 930 940 950
PLVNAPHTAA MVIDGEWTYP YSRETAAFPL PYIRTNKFWP SVARVDDAYG
960
DKNLMCSCPS IENYM
Length:965
Mass (Da):105,692
Last modified:May 16, 2006 - v1
Checksum:i02AA48F292B797E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE74586.1.
RefSeqiWP_011513150.1. NC_007969.1.

Genome annotation databases

EnsemblBacteriaiABE74586; ABE74586; Pcryo_0803.
KEGGipcr:Pcryo_0803.
PATRICi23061091. VBIPsyCry128170_0873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE74586.1.
RefSeqiWP_011513150.1. NC_007969.1.

3D structure databases

ProteinModelPortaliQ1QCL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335284.Pcryo_0803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE74586; ABE74586; Pcryo_0803.
KEGGipcr:Pcryo_0803.
PATRICi23061091. VBIPsyCry128170_0873.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-830-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR000192. Aminotrans_V_dom.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Psychrobacter cryohalolentis K5."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K5.

Entry informationi

Entry nameiGCSP_PSYCK
AccessioniPrimary (citable) accession number: Q1QCL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.