ID   HUTH_PSYCK              Reviewed;         520 AA.
AC   Q1Q9E4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Histidine ammonia-lyase;
DE            Short=Histidase;
DE            EC=4.3.1.3;
GN   Name=hutH; OrderedLocusNames=Pcryo_1932;
OS   Psychrobacter cryohalolentis (strain K5).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Psychrobacter.
OX   NCBI_TaxID=335284;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T.,
RA   Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.;
RT   "Complete sequence of chromosome of Psychrobacter cryohalolentis K5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO),
CC       which is formed autocatalytically by cyclization and dehydration
CC       of residues Ala-Ser-Gly (By similarity).
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
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DR   EMBL; CP000323; ABE75709.1; -; Genomic_DNA.
DR   RefSeq; YP_581193.1; -.
DR   GeneID; 4034669; -.
DR   GenomeReviews; CP000323_GR; Pcryo_1932.
DR   KEGG; pcr:Pcryo_1932; -.
DR   NMPDR; fig|335284.3.peg.2412; -.
DR   HOGENOM; Q1Q9E4; -.
DR   OMA; Q1Q9E4; FAPDIEA.
DR   BioCyc; PCRY335284:PCRYO_1932-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016211; F:ammonia ligase activity; IEA:InterPro.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:HAMAP.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006548; P:histidine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00229; -; 1.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR001106; Phe/His_NH3-lyase.
DR   Pfam; PF00221; PAL; 1.
DR   TIGRFAMs; TIGR01225; hutH; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Lyase.
FT   CHAIN         1    520       Histidine ammonia-lyase.
FT                                /FTId=PRO_1000021567.
FT   MOD_RES     147    147       2,3-didehydroalanine (Ser) (By
FT                                similarity).
FT   CROSSLNK    146    148       5-imidazolinone (Ala-Gly) (By
FT                                similarity).
SQ   SEQUENCE   520 AA;  55756 MW;  1FD92E53A3EEF57E CRC64;
     MTAIKKLTLQ PRQLSFEILR DIYEQPVILT LPDSAYEAID ASHEDVQTII RRDKSAYGIN
     TGFGLLAKTR ISDDQLELLQ RNLIVSHSVG TGEALPANVV RLIMVMKVTS LAQGVSGVRR
     AVVDSLLGLI NNQITPNIPA KGSVGASGDL APLSHMTLAM MGEGHVYVDG NKVLAADALA
     QHGLEPITLA AKEGLALING TQVSTALALR GYFLARDLLE TATIVGSLSI DAAKGSDAPF
     DARIHEVRGH HGQIEIAKAH RQLIKGSAIR ASHDGEQDDR VQDPYCLRCQ PQVMGACLDI
     INQAGKTLLI ESNAVTDNPL IFNNEDGPVA ISGGNFHAEP VAFAADILAL AIAEIGSMSE
     RRIALLIDAT LSGGLPPFLV DNAGVNSGFM IAHVTAAALA SENKSIAHPG SVDSIPTSAN
     QEDHVSMATY CARRLYEMAQ NTATIIGIEL LAAGQGIDFH RGLETSEPLT MAHQKLREQV
     TFYDKDRYLA PDIEAAKQLV LDGTLAEHWQ PLRSNWYDSK
//