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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Pcryo_2243
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000002425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000683551 – 173Peptide methionine sulfoxide reductase MsrAAdd BLAST173

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_2243

Structurei

3D structure databases

ProteinModelPortaliQ1Q8I3
SMRiQ1Q8I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

Q1Q8I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIILGGGC FWCTESVFLS VKGVQSVISG YMGGDAVSAN YEAVCGGNTG
60 70 80 90 100
HVEVIKVEFD ESIVPLEVIL DVFFATHDPT TMDRQGNDVG SQYRSVVFYT
110 120 130 140 150
DETQKPTIDR TINKLRDMGI NVVTEVHPAV EFYQAEDTHQ DFFNRNPGQA
160 170
YCNFAIPPKL AKLRKEFSQY MVS
Length:173
Mass (Da):19,278
Last modified:May 16, 2006 - v1
Checksum:i8A491C613D248A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA Translation: ABE76020.1
RefSeqiWP_011514553.1, NC_007969.1

Genome annotation databases

EnsemblBacteriaiABE76020; ABE76020; Pcryo_2243
KEGGipcr:Pcryo_2243

Similar proteinsi

Entry informationi

Entry nameiMSRA_PSYCK
AccessioniPrimary (citable) accession number: Q1Q8I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health