Reviewed, UniProtKB/Swiss-Prot Q1Q8I2 (TPMT_PSYCK)

Names and origin

Protein names

Recommended name:
    Thiopurine S-methyltransferase
    EC=2.1.1.67
Alternative name(s):
    Thiopurine methyltransferase

Gene names

Name:	tpm
Ordered Locus Names:	Pcryo_2244

Organism

Psychrobacter cryohalolentis (strain K5) [Complete proteome] [HAMAP]

Taxonomic identifier

335284 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Psychrobacter

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Thiopurine S-methyltransferase HAMAP MF_00812		PRO_1000134079
Sites
	Binding site	10	1	S-adenosyl-L-methionine By similarity
	Binding site	45	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	66	1	S-adenosyl-L-methionine By similarity
	Binding site	130	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1Q8I2-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 15A83E56904409E7	FASTA	219	25,045
	10 20 30 40 50 60 MNPEFWQARW KEKRIGFNQP KVNPLLIKYF SDLKMATGSR IFIPLCGKSI DMIWLANQGF 70 80 90 100 110 120 DMVGVELVES AVQEFFAENN ISYTIKAHDK NSNIKCYQGQ LSGQTIALWV ADIFMLRTND 130 140 150 160 170 180 VGRVDAVYDR AALIAMPAEL RPQYSQQVID LSQNAHQLLL TLNYDQNERA GPPFSISHEQ 190 200 210 IQQYYSAHYQ IQELEGKPST LNAAPEMTVT ENVWLLNKP

References

[1]

"Complete sequence of chromosome of Psychrobacter cryohalolentis K5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Sims D.R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000323 Genomic DNA. Translation: ABE76021.1.
RefSeq	YP_581505.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1Q8I2.
Genome annotation databases
GeneID	4035542.
GenomeReviews	Gene locus Pcryo_2244 in contig CP000323_GR.
KEGG	pcr:Pcryo_2244.
NMPDR	fig|335284.3.peg.2245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1Q8I2.
OMA	PPFAVSP.
Enzyme and pathway databases
BioCyc	PCRY335284:PCRYO_2244-MON.
Family and domain databases
HAMAP	MF_00812. [Tree]
InterPro	IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPMT_PSYCK

Accession

Primary (citable) accession number: Q1Q8I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)