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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Psychrobacter cryohalolentis (strain K5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-2359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Pcryo_2310
OrganismiPsychrobacter cryohalolentis (strain K5)
Taxonomic identifieri335284 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaePsychrobacter
Proteomesi
  • UP000002425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173RNA pyrophosphohydrolasePRO_1000021976Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335284.Pcryo_2310.

Structurei

3D structure databases

ProteinModelPortaliQ1Q8B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 149144Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 5922Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066723.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1Q8B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDADGFRAN VGIILANTQG QVLWAKRIGH NAWQFPQGGI DRGETPMDAM
60 70 80 90 100
YRELWEEVGL HPRHVDLLAV TQDWLRYRLP KRYVRHGQYP LCIGQKQKWF
110 120 130 140 150
LLRLDEPNTQ HIRFDEGKPE FDNWQWVSYW YPLGQVIHFK RSVYRRALQE
160 170
LVPELPLQQG LIIPEQNNHL LVE
Length:173
Mass (Da):20,565
Last modified:May 16, 2006 - v1
Checksum:i43E542E319362751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE76087.1.
RefSeqiWP_011514617.1. NC_007969.1.

Genome annotation databases

EnsemblBacteriaiABE76087; ABE76087; Pcryo_2310.
KEGGipcr:Pcryo_2310.
PATRICi23064265. VBIPsyCry128170_2440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000323 Genomic DNA. Translation: ABE76087.1.
RefSeqiWP_011514617.1. NC_007969.1.

3D structure databases

ProteinModelPortaliQ1Q8B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi335284.Pcryo_2310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE76087; ABE76087; Pcryo_2310.
KEGGipcr:Pcryo_2310.
PATRICi23064265. VBIPsyCry128170_2440.

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066723.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Enzyme and pathway databases

BioCyciPCRY335284:GHE9-2359-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPPH_PSYCK
AccessioniPrimary (citable) accession number: Q1Q8B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.