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Q1PHW8 (Q1PHW8_9ENTO) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismHuman poliovirus 1 EMBL ABE02680.1
Taxonomic identifier12080 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeEnterovirusEnterovirus C

Protein attributes

Sequence length1670 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

NTP + H2O = NDP + phosphate. SAAS SAAS000605

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). SAAS SAAS000605

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. SAAS SAAS000605

Subcellular location

Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity SAAS SAAS000605.

Sequence similarities

Contains RdRp catalytic domain. SAAS SAAS000605

Contains SF3 helicase domain. SAAS SAAS000605

Contains SFhelicase domain. SAAS SAAS000605

Ontologies

Keywords
   Biological processHost-virus interaction
Ion transport
Transport
Viral attachment to host cell SAAS SAAS000605
Viral RNA replication SAAS SAAS000605
Virus entry into host cell
   Cellular componentCapsid protein SAAS SAAS000605
Host cytoplasm SAAS SAAS000605
Host cytoplasmic vesicle SAAS SAAS000605
Host membrane SAAS SAAS000605
Membrane
Virion
   LigandATP-binding
Metal-binding PDB 2IJD
Nucleotide-binding
RNA-binding SAAS SAAS000605
Zinc PDB 2IJD
   Molecular functionHelicase SAAS SAAS001205
Hydrolase
Ion channel
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase SAAS SAAS000605
Thiol protease SAAS SAAS000605
Transferase
Viral ion channel SAAS SAAS000605
   PTMPhosphoprotein SAAS SAAS000605
   Technical term3D-structure PDB 2IJD
Gene Ontology (GO)
   Biological_processRNA-protein covalent cross-linking

Inferred from electronic annotation. Source: InterPro

pore formation by virus in membrane of host cell

Inferred from electronic annotation. Source: UniProtKB-KW

protein oligomerization

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane of host cell

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

ion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region1373 – 13764Sulfate 2 binding PDB 2IJD

Sites

Metal binding14721Zinc PDB 2IJD
Metal binding14791Zinc; via tele nitrogen PDB 2IJD
Metal binding14811Zinc; via pros nitrogen PDB 2IJD
Metal binding14901Zinc PDB 2IJD
Binding site11601Sulfate 1 PDB 2IJD
Binding site15681Sulfate 2 PDB 2IJD
Binding site16241Sulfate 3 PDB 2IJD
Binding site16571Sulfate 3 PDB 2IJD
Binding site16651Sulfate 3 PDB 2IJD

Experimental info

Non-terminal residue11 EMBL ABE02680.1

Sequences

Sequence LengthMass (Da)Tools
Q1PHW8 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 31D825913C635FCE

FASTA1,670186,996
        10         20         30         40         50         60 
VVPLSTPREM DILGFVSACN DFSVRLLRDT THIEQKALAQ GLGQMLESMI DNTVRETVGA 

        70         80         90        100        110        120 
ATSRDALPNT EASGPAHSKE IPALTAVETG ATNPLVPSDT VQTRHVIQHR SRSESSIESF 

       130        140        150        160        170        180 
FARGACVTIM TVDNSASTGS KDKLFTVWKI TYKDTVQLRR KLEFFTYSRF DMEFTFVVTA 

       190        200        210        220        230        240 
NFTETNNGHA LNQVYQIMYV PPGAPVPKEW DDYTWQTSSN PSIFYTYGTA PARISIPYVG 

       250        260        270        280        290        300 
ISNAYSHFYD GFSKIPLKDQ TAALGDSLYG AASLNDFGIL AVRVVNDHNP TKVTSKIRVY 

       310        320        330        340        350        360 
LKPKHIRVWC PRPPRAVAYY GPGVDYKDGT LTPLPTKDLT TYGFGHQNKA VYTAGYKICN 

       370        380        390        400        410        420 
YHLATQEDLQ NAVNVMWDRD LLVTESRSQG TDSIARCNCN TGVYYCESRR KYYPVSFVGP 

       430        440        450        460        470        480 
TFQYMEANDY YPARYQSHML IGHGFASPGD CGGILRCRHG VIGIITAGGE GLVAFSDIRD 

       490        500        510        520        530        540 
LYAYEEEAME QGITNYIESL GAAFGSGFTQ QIGDKITELT NMVTSTITEK LLKNLIKIIS 

       550        560        570        580        590        600 
SLVIITRNYE DTTTVLATLA LLGCDISPWQ WLKKKACDVL EIPYVIKQGD SWLKKFTEAC 

       610        620        630        640        650        660 
NAAKGLEWVS NKISKFIDWL KEKIIPQARD KLEFVTKLRQ LEMLENQIST IHQSCPSQEH 

       670        680        690        700        710        720 
QEILFNNVRW LSIQSKRFAP LYAVEAKRIQ KLEHTINNYI QFKSKHRIEP VCLLVHGSPG 

       730        740        750        760        770        780 
TGKSVATNLI ARAIAERENT STYSLPPDPS HFDGYKQQGV VIMDDLNQNP DGADMKLFCQ 

       790        800        810        820        830        840 
MVSTVEFIPP MASLEEKGIL FTSNYVLAST NSSRISPPTV AHSDALARRF AFDMDIQVMN 

       850        860        870        880        890        900 
EYSRDGKLNM AMATEMCKNC HQPANFKRCC PLVCGKAIQL MDKSSRVRYS IDQITTMIIN 

       910        920        930        940        950        960 
ERNRRSNIGN CMEALFQGPL QYKDLKIDIK TSPPPECIND LLQAVDSQEV RDYCEKKGWI 

       970        980        990       1000       1010       1020 
VNITSQVQTE RNINRAMTIL QAVTTFAAVA GVVYVMYKLF AGHQGAYTGL PNKKPNVPTI 

      1030       1040       1050       1060       1070       1080 
RTAKVQGPGF DYAVAMAKRN IVTATTSKGE FTMLGVHDNV AILPTHASPG ESIVIDGKEV 

      1090       1100       1110       1120       1130       1140 
EILDAKALED QAGTNLEITI ITLKRNEKFR DIRPHIPTQI TETNDGVLIV NTSKYPNMYV 

      1150       1160       1170       1180       1190       1200 
PVGAVTEQGY LNLGGRQTAR TLMYNFPTRA GQCGGVITCT GKVIGMHVGG NGSHGFAAAL 

      1210       1220       1230       1240       1250       1260 
KRSYFTQSQG EIQWMRPSKE VGYPIINAPS KTKLEPSAFH YVFEGVKEPA VLTKNDPRLK 

      1270       1280       1290       1300       1310       1320 
TDFEEAIFSK YVGNKITEVD EYMKEAVDHY AGQLMSLDIN TEQMCLEDAM YGTDGLEALD 

      1330       1340       1350       1360       1370       1380 
LSTSAGYPYV AMGKKKRDIL NKQTRDTKEM QKLLDTYGIN LPLVTYVKDE LRSKTKVEMG 

      1390       1400       1410       1420       1430       1440 
KSRLIEASSL NDSVAMRMAF GNLYAAFHKN PGVVTGSAVG CDPDLFWSKI PVLMEEKLFA 

      1450       1460       1470       1480       1490       1500 
FDYTGYDASL SPAWFEALKM VLEKIGFGDR VDYIDYLNHS HHLYKNKTYC VKGGMPSGCS 

      1510       1520       1530       1540       1550       1560 
GTSIFNSMIN NLIIRTLLLK TYKGIDLDHL KMIAYGDDVI ASYPHEVDAS LLAQSGKDYG 

      1570       1580       1590       1600       1610       1620 
LTMTPADKSA TFETVTWENV TFLKRFFRAD EKYPFLIHPV MPMKEIHESI RWTKDPRNTQ 

      1630       1640       1650       1660       1670 
DHVRSLCLLA WHNGEEEYNK FLAKIRSVPI GRALLLPEYS TLYRRWLDSF 

« Hide

References

[1]"Genetic drift of poliovirus type 1 during 51 months of prolonged intestinal replication in an immunodeficient patient."
Vollnberg B., Diedrich S., Schreier E.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PV1/00-87/DEU EMBL ABE02680.1.
[2]"Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase."
Marcotte L.L., Wass A.B., Gohara D.W., Pathak H.B., Arnold J.J., Filman D.J., Cameron C.E., Hogle J.M.
J. Virol. 81:3583-3596(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 1027-1670 IN COMPLEX WITH SULFATE AND ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ411563 Genomic RNA. Translation: ABE02680.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IJDX-ray3.401/21027-1670[»]
ProteinModelPortalQ1PHW8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.20. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR014838. P3A.
IPR000081. Peptidase_C3.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR002527. Pico_P2B.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR009003. Trypsin-like_Pept_dom.
IPR029053. Viral_coat.
[Graphical view]
PfamPF08727. P3A. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF00947. Pico_P2A. 1 hit.
PF01552. Pico_P2B. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 1 hit.
PF00910. RNA_helicase. 1 hit.
[Graphical view]
ProDomPD001306. Peptidase_C3. 1 hit.
PD649346. Pico_P2B. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF89043. SSF89043. 1 hit.
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1PHW8_9ENTO
AccessionPrimary (citable) accession number: Q1PHW8
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)