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Protein

Genome polyprotein

Gene
N/A
Organism
Human poliovirus 1
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1472ZincCombined sources1
Metal bindingi1479Zinc; via tele nitrogenCombined sources1
Metal bindingi1481Zinc; via pros nitrogenCombined sources1
Metal bindingi1490ZincCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-bindingSAAS annotation, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation
Biological processHost-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell
LigandATP-binding, Metal-bindingCombined sources, Nucleotide-binding, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiHuman poliovirus 1Imported
Taxonomic identifieri12080 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeEnterovirusEnterovirus C

Subcellular locationi

  • Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation
  • Virion SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IJDX-ray3.401/21027-1670[»]
ProteinModelPortaliQ1PHW8
SMRiQ1PHW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini693 – 849SF3 helicaseInterPro annotationAdd BLAST157
Domaini1436 – 1551RdRp catalyticInterPro annotationAdd BLAST116

Family and domain databases

CDDicd00205 rhv_like, 1 hit
Gene3Di1.10.10.870, 1 hit
2.60.120.20, 1 hit
InterProiView protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR027417 P-loop_NTPase
IPR014838 P3A
IPR036203 P3A_soluble_dom
IPR000081 Peptidase_C3
IPR000199 Peptidase_C3A/C3B_picornavir
IPR009003 Peptidase_S1_PA
IPR002527 Pico_P2B
IPR001676 Picornavirus_capsid
IPR033703 Rhv-like
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR029053 Viral_coat
PfamiView protein in Pfam
PF08727 P3A, 1 hit
PF00548 Peptidase_C3, 1 hit
PF00947 Pico_P2A, 1 hit
PF01552 Pico_P2B, 1 hit
PF00680 RdRP_1, 1 hit
PF00073 Rhv, 1 hit
PF00910 RNA_helicase, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001306 Peptidase_C3, 1 hit
PD649346 Pico_P2B, 1 hit
SUPFAMiSSF50494 SSF50494, 2 hits
SSF52540 SSF52540, 1 hit
SSF89043 SSF89043, 1 hit
PROSITEiView protein in PROSITE
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q1PHW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VVPLSTPREM DILGFVSACN DFSVRLLRDT THIEQKALAQ GLGQMLESMI
60 70 80 90 100
DNTVRETVGA ATSRDALPNT EASGPAHSKE IPALTAVETG ATNPLVPSDT
110 120 130 140 150
VQTRHVIQHR SRSESSIESF FARGACVTIM TVDNSASTGS KDKLFTVWKI
160 170 180 190 200
TYKDTVQLRR KLEFFTYSRF DMEFTFVVTA NFTETNNGHA LNQVYQIMYV
210 220 230 240 250
PPGAPVPKEW DDYTWQTSSN PSIFYTYGTA PARISIPYVG ISNAYSHFYD
260 270 280 290 300
GFSKIPLKDQ TAALGDSLYG AASLNDFGIL AVRVVNDHNP TKVTSKIRVY
310 320 330 340 350
LKPKHIRVWC PRPPRAVAYY GPGVDYKDGT LTPLPTKDLT TYGFGHQNKA
360 370 380 390 400
VYTAGYKICN YHLATQEDLQ NAVNVMWDRD LLVTESRSQG TDSIARCNCN
410 420 430 440 450
TGVYYCESRR KYYPVSFVGP TFQYMEANDY YPARYQSHML IGHGFASPGD
460 470 480 490 500
CGGILRCRHG VIGIITAGGE GLVAFSDIRD LYAYEEEAME QGITNYIESL
510 520 530 540 550
GAAFGSGFTQ QIGDKITELT NMVTSTITEK LLKNLIKIIS SLVIITRNYE
560 570 580 590 600
DTTTVLATLA LLGCDISPWQ WLKKKACDVL EIPYVIKQGD SWLKKFTEAC
610 620 630 640 650
NAAKGLEWVS NKISKFIDWL KEKIIPQARD KLEFVTKLRQ LEMLENQIST
660 670 680 690 700
IHQSCPSQEH QEILFNNVRW LSIQSKRFAP LYAVEAKRIQ KLEHTINNYI
710 720 730 740 750
QFKSKHRIEP VCLLVHGSPG TGKSVATNLI ARAIAERENT STYSLPPDPS
760 770 780 790 800
HFDGYKQQGV VIMDDLNQNP DGADMKLFCQ MVSTVEFIPP MASLEEKGIL
810 820 830 840 850
FTSNYVLAST NSSRISPPTV AHSDALARRF AFDMDIQVMN EYSRDGKLNM
860 870 880 890 900
AMATEMCKNC HQPANFKRCC PLVCGKAIQL MDKSSRVRYS IDQITTMIIN
910 920 930 940 950
ERNRRSNIGN CMEALFQGPL QYKDLKIDIK TSPPPECIND LLQAVDSQEV
960 970 980 990 1000
RDYCEKKGWI VNITSQVQTE RNINRAMTIL QAVTTFAAVA GVVYVMYKLF
1010 1020 1030 1040 1050
AGHQGAYTGL PNKKPNVPTI RTAKVQGPGF DYAVAMAKRN IVTATTSKGE
1060 1070 1080 1090 1100
FTMLGVHDNV AILPTHASPG ESIVIDGKEV EILDAKALED QAGTNLEITI
1110 1120 1130 1140 1150
ITLKRNEKFR DIRPHIPTQI TETNDGVLIV NTSKYPNMYV PVGAVTEQGY
1160 1170 1180 1190 1200
LNLGGRQTAR TLMYNFPTRA GQCGGVITCT GKVIGMHVGG NGSHGFAAAL
1210 1220 1230 1240 1250
KRSYFTQSQG EIQWMRPSKE VGYPIINAPS KTKLEPSAFH YVFEGVKEPA
1260 1270 1280 1290 1300
VLTKNDPRLK TDFEEAIFSK YVGNKITEVD EYMKEAVDHY AGQLMSLDIN
1310 1320 1330 1340 1350
TEQMCLEDAM YGTDGLEALD LSTSAGYPYV AMGKKKRDIL NKQTRDTKEM
1360 1370 1380 1390 1400
QKLLDTYGIN LPLVTYVKDE LRSKTKVEMG KSRLIEASSL NDSVAMRMAF
1410 1420 1430 1440 1450
GNLYAAFHKN PGVVTGSAVG CDPDLFWSKI PVLMEEKLFA FDYTGYDASL
1460 1470 1480 1490 1500
SPAWFEALKM VLEKIGFGDR VDYIDYLNHS HHLYKNKTYC VKGGMPSGCS
1510 1520 1530 1540 1550
GTSIFNSMIN NLIIRTLLLK TYKGIDLDHL KMIAYGDDVI ASYPHEVDAS
1560 1570 1580 1590 1600
LLAQSGKDYG LTMTPADKSA TFETVTWENV TFLKRFFRAD EKYPFLIHPV
1610 1620 1630 1640 1650
MPMKEIHESI RWTKDPRNTQ DHVRSLCLLA WHNGEEEYNK FLAKIRSVPI
1660 1670
GRALLLPEYS TLYRRWLDSF
Length:1,670
Mass (Da):186,996
Last modified:May 16, 2006 - v1
Checksum:i31D825913C635FCE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ411563 Genomic RNA Translation: ABE02680.1

Similar proteinsi

Entry informationi

Entry nameiQ1PHW8_9ENTO
AccessioniPrimary (citable) accession number: Q1PHW8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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