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Q1PHM9

- Q1PHM9_9HIV1

UniProt

Q1PHM9 - Q1PHM9_9HIV1

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Protein
Envelope glycoprotein gp160
Gene
env
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity.UniRule annotationSAAS annotations
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.SAAS annotations

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotations, Fusion of virus membrane with host membraneSAAS annotations, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotations, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host endosomeSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationsImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U4EX-ray2.18G/J125-244[»]

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q1PHM9-1 [UniParc]FASTAAdd to Basket

« Hide

MRVRGILRNW PQWWIWSILG FWMLIICRVM GNLWVTVYYG VPVWKEAKAT    50
LFCASDARAY EKEVHNVWAT HACVPTDPNP QEIYLGNVTE NFNMWKNDMV 100
DQMHEDIISL WDQSLKPCVK LTPLCVTLRC TNATINGSLT EEVKNCSFNI 150
TTELRDKKQK AYALFYRPDV VPLNKNSPSG NSSEYILINC NTSTITQACP 200
KVSFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS 250
TQLLLNGSLA EEDIIIKSEN LTNNIKTIIV HLNKSVEIVC RRPNNNTRKS 300
IRIGPGQAFY ATNDIIGDIR QAHCNINNST WNRTLEQIKK KLREHFLNRT 350
IEFEPPSGGD LEVTTHSFNC GGEFFYCNTT RLFKWSSNVT NDTITIPCRI 400
KQFINMWQGA GRAMYAPPIE GNITCNSSIT GLLLTRDGGK TDRNDTEIFR 450
PGGGNMKDNW RNELYKYKVV EIKPLGVAPT EARRRVVERE KRAVGIGAVL 500
LGFLGAAGST MGAASITLTV QARQLLSGIV QQQSNLLRAI EAQQHMLQLT 550
VWGIKQLQTR VLAIERYLKD QQLLGLWGCS GKLICTTNVP WNSSWSNKSQ 600
TDIWDNMTWI QWDREISNYS NTIYKLLEGS QNQQEQNEKD LLALDSWNNL 650
WNWFNITNWL WYIKIFIMII GGLIGLRIIL GVLSIVKRVR QGYSPLSFQT 700
LTPNPRGLDR LGRIEEEGGE QDKDRSIRLV NGFLALAWED LRSLCLFSYH 750
RLRDFILIAV RAVELLGSSS LRGLQRGWEA LKYLGSLLQY WGLELKKSAI 800
NLLDTVAIAV AEGTDRIIEL IQRICRAIRN IPRRIRQGFE AALL 844
Length:844
Mass (Da):95,900
Last modified:May 16, 2006 - v1
Checksum:iE372CBCC8DAEE5F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U4E X-ray 2.18 G/J 125-244 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa."
    Li M., Salazar-Gonzalez J.F., Derdeyn C.A., Morris L., Williamson C., Robinson J.E., Decker J.M., Li Y., Salazar M.G., Polonis V.R., Mlisana K., Karim S.A., Hong K., Greene K.M., Bilska M., Zhou J., Allen S., Chomba E.
    , Mulenga J., Vwalika C., Gao F., Zhang M., Korber B.T., Hunter E., Hahn B.H., Montefiori D.C.
    J. Virol. 80:11776-11790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CAP45.2.00.G3Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 125-244.

Entry informationi

Entry nameiQ1PHM9_9HIV1
AccessioniPrimary (citable) accession number: Q1PHM9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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