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Q1PHM9

- Q1PHM9_9HIV1

UniProt

Q1PHM9 - Q1PHM9_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U4EX-ray2.18G/J125-244[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q1PHM9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVRGILRNW PQWWIWSILG FWMLIICRVM GNLWVTVYYG VPVWKEAKAT
60 70 80 90 100
LFCASDARAY EKEVHNVWAT HACVPTDPNP QEIYLGNVTE NFNMWKNDMV
110 120 130 140 150
DQMHEDIISL WDQSLKPCVK LTPLCVTLRC TNATINGSLT EEVKNCSFNI
160 170 180 190 200
TTELRDKKQK AYALFYRPDV VPLNKNSPSG NSSEYILINC NTSTITQACP
210 220 230 240 250
KVSFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS
260 270 280 290 300
TQLLLNGSLA EEDIIIKSEN LTNNIKTIIV HLNKSVEIVC RRPNNNTRKS
310 320 330 340 350
IRIGPGQAFY ATNDIIGDIR QAHCNINNST WNRTLEQIKK KLREHFLNRT
360 370 380 390 400
IEFEPPSGGD LEVTTHSFNC GGEFFYCNTT RLFKWSSNVT NDTITIPCRI
410 420 430 440 450
KQFINMWQGA GRAMYAPPIE GNITCNSSIT GLLLTRDGGK TDRNDTEIFR
460 470 480 490 500
PGGGNMKDNW RNELYKYKVV EIKPLGVAPT EARRRVVERE KRAVGIGAVL
510 520 530 540 550
LGFLGAAGST MGAASITLTV QARQLLSGIV QQQSNLLRAI EAQQHMLQLT
560 570 580 590 600
VWGIKQLQTR VLAIERYLKD QQLLGLWGCS GKLICTTNVP WNSSWSNKSQ
610 620 630 640 650
TDIWDNMTWI QWDREISNYS NTIYKLLEGS QNQQEQNEKD LLALDSWNNL
660 670 680 690 700
WNWFNITNWL WYIKIFIMII GGLIGLRIIL GVLSIVKRVR QGYSPLSFQT
710 720 730 740 750
LTPNPRGLDR LGRIEEEGGE QDKDRSIRLV NGFLALAWED LRSLCLFSYH
760 770 780 790 800
RLRDFILIAV RAVELLGSSS LRGLQRGWEA LKYLGSLLQY WGLELKKSAI
810 820 830 840
NLLDTVAIAV AEGTDRIIEL IQRICRAIRN IPRRIRQGFE AALL
Length:844
Mass (Da):95,900
Last modified:May 16, 2006 - v1
Checksum:iE372CBCC8DAEE5F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3U4E X-ray 2.18 G/J 125-244 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa."
    Li M., Salazar-Gonzalez J.F., Derdeyn C.A., Morris L., Williamson C., Robinson J.E., Decker J.M., Li Y., Salazar M.G., Polonis V.R., Mlisana K., Karim S.A., Hong K., Greene K.M., Bilska M., Zhou J., Allen S., Chomba E.
    , Mulenga J., Vwalika C., Gao F., Zhang M., Korber B.T., Hunter E., Hahn B.H., Montefiori D.C.
    J. Virol. 80:11776-11790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CAP45.2.00.G3Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 125-244.

Entry informationi

Entry nameiQ1PHM9_9HIV1
AccessioniPrimary (citable) accession number: Q1PHM9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3