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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 41HelicalUniRule annotationAdd BLAST29
Transmembranei493 – 516HelicalUniRule annotationAdd BLAST24
Transmembranei659 – 686HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi125 ↔ 190Combined sources
Disulfide bondi130 ↔ 146Combined sources

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U4EX-ray2.19G/J125-244[»]
SMRiQ1PHM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 134GP120InterPro annotationAdd BLAST102
Domaini132 – 492GP120InterPro annotationAdd BLAST361
Domaini511 – 702GP41InterPro annotationAdd BLAST192

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1PHM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRGILRNW PQWWIWSILG FWMLIICRVM GNLWVTVYYG VPVWKEAKAT
60 70 80 90 100
LFCASDARAY EKEVHNVWAT HACVPTDPNP QEIYLGNVTE NFNMWKNDMV
110 120 130 140 150
DQMHEDIISL WDQSLKPCVK LTPLCVTLRC TNATINGSLT EEVKNCSFNI
160 170 180 190 200
TTELRDKKQK AYALFYRPDV VPLNKNSPSG NSSEYILINC NTSTITQACP
210 220 230 240 250
KVSFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS
260 270 280 290 300
TQLLLNGSLA EEDIIIKSEN LTNNIKTIIV HLNKSVEIVC RRPNNNTRKS
310 320 330 340 350
IRIGPGQAFY ATNDIIGDIR QAHCNINNST WNRTLEQIKK KLREHFLNRT
360 370 380 390 400
IEFEPPSGGD LEVTTHSFNC GGEFFYCNTT RLFKWSSNVT NDTITIPCRI
410 420 430 440 450
KQFINMWQGA GRAMYAPPIE GNITCNSSIT GLLLTRDGGK TDRNDTEIFR
460 470 480 490 500
PGGGNMKDNW RNELYKYKVV EIKPLGVAPT EARRRVVERE KRAVGIGAVL
510 520 530 540 550
LGFLGAAGST MGAASITLTV QARQLLSGIV QQQSNLLRAI EAQQHMLQLT
560 570 580 590 600
VWGIKQLQTR VLAIERYLKD QQLLGLWGCS GKLICTTNVP WNSSWSNKSQ
610 620 630 640 650
TDIWDNMTWI QWDREISNYS NTIYKLLEGS QNQQEQNEKD LLALDSWNNL
660 670 680 690 700
WNWFNITNWL WYIKIFIMII GGLIGLRIIL GVLSIVKRVR QGYSPLSFQT
710 720 730 740 750
LTPNPRGLDR LGRIEEEGGE QDKDRSIRLV NGFLALAWED LRSLCLFSYH
760 770 780 790 800
RLRDFILIAV RAVELLGSSS LRGLQRGWEA LKYLGSLLQY WGLELKKSAI
810 820 830 840
NLLDTVAIAV AEGTDRIIEL IQRICRAIRN IPRRIRQGFE AALL
Length:844
Mass (Da):95,900
Last modified:May 16, 2006 - v1
Checksum:iE372CBCC8DAEE5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ435682 Genomic DNA. Translation: ABE02700.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U4EX-ray2.19G/J125-244[»]
SMRiQ1PHM9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ1PHM9_9HIV1
AccessioniPrimary (citable) accession number: Q1PHM9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.