Q1PHM9 (Q1PHM9_9HIV1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Envelope glycoprotein gp160 RuleBase RU004292

Gene names

Name:

env EMBL ABE02700.1

Organism

Human immunodeficiency virus 1 EMBL ABE02700.1

Taxonomic identifier

11676 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	844 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328 The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.

Ontologies

Keywords
Biological process	Apoptosis SAAS SAAS000328 Fusion of virus membrane with host membrane SAAS SAAS000328 Host-virus interaction Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328 Viral immunoevasion RuleBase RU004292 Viral penetration into host cytoplasm Virus entry into host cell
Cellular component	Host cell membrane SAAS SAAS000328 Host endosome SAAS SAAS000328 Host membrane Membrane Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL ABE02700.1 Virion
Disease	AIDS RuleBase RU003294
Domain	Transmembrane Transmembrane helix SAAS SAAS000328
PTM	Cleavage on pair of basic residues RuleBase RU004292 Disulfide bond SAAS SAAS000328
Technical term	3D-structure PDB 3U4E
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW evasion or tolerance by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endosome Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1PHM9 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: E372CBCC8DAEE5F4	FASTA	844	95,900
	10 20 30 40 50 60 MRVRGILRNW PQWWIWSILG FWMLIICRVM GNLWVTVYYG VPVWKEAKAT LFCASDARAY 70 80 90 100 110 120 EKEVHNVWAT HACVPTDPNP QEIYLGNVTE NFNMWKNDMV DQMHEDIISL WDQSLKPCVK 130 140 150 160 170 180 LTPLCVTLRC TNATINGSLT EEVKNCSFNI TTELRDKKQK AYALFYRPDV VPLNKNSPSG 190 200 210 220 230 240 NSSEYILINC NTSTITQACP KVSFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ 250 260 270 280 290 300 CTHGIKPVVS TQLLLNGSLA EEDIIIKSEN LTNNIKTIIV HLNKSVEIVC RRPNNNTRKS 310 320 330 340 350 360 IRIGPGQAFY ATNDIIGDIR QAHCNINNST WNRTLEQIKK KLREHFLNRT IEFEPPSGGD 370 380 390 400 410 420 LEVTTHSFNC GGEFFYCNTT RLFKWSSNVT NDTITIPCRI KQFINMWQGA GRAMYAPPIE 430 440 450 460 470 480 GNITCNSSIT GLLLTRDGGK TDRNDTEIFR PGGGNMKDNW RNELYKYKVV EIKPLGVAPT 490 500 510 520 530 540 EARRRVVERE KRAVGIGAVL LGFLGAAGST MGAASITLTV QARQLLSGIV QQQSNLLRAI 550 560 570 580 590 600 EAQQHMLQLT VWGIKQLQTR VLAIERYLKD QQLLGLWGCS GKLICTTNVP WNSSWSNKSQ 610 620 630 640 650 660 TDIWDNMTWI QWDREISNYS NTIYKLLEGS QNQQEQNEKD LLALDSWNNL WNWFNITNWL 670 680 690 700 710 720 WYIKIFIMII GGLIGLRIIL GVLSIVKRVR QGYSPLSFQT LTPNPRGLDR LGRIEEEGGE 730 740 750 760 770 780 QDKDRSIRLV NGFLALAWED LRSLCLFSYH RLRDFILIAV RAVELLGSSS LRGLQRGWEA 790 800 810 820 830 840 LKYLGSLLQY WGLELKKSAI NLLDTVAIAV AEGTDRIIEL IQRICRAIRN IPRRIRQGFE AALL

References

[1]

"Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa." Li M., Salazar-Gonzalez J.F., Derdeyn C.A., Morris L., Williamson C., Robinson J.E., Decker J.M., Li Y., Salazar M.G., Polonis V.R., Mlisana K., Karim S.A., Hong K., Greene K.M., Bilska M., Zhou J., Allen S., Chomba E. , Mulenga J., Vwalika C., Gao F., Zhang M., Korber B.T., Hunter E., Hahn B.H., Montefiori D.C. J. Virol. 80:11776-11790(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CAP45.2.00.G3 EMBL ABE02700.1.

[2]

"Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9." McLellan J.S., Pancera M., Carrico C., Gorman J., Julien J.P., Khayat R., Louder R., Pejchal R., Sastry M., Dai K., O'Dell S., Patel N., Shahzad-ul-Hussan S., Yang Y., Zhang B., Zhou T., Zhu J., Boyington J.C. , Chuang G.Y., Diwanji D., Georgiev I., Kwon Y.D., Lee D., Louder M.K., Moquin S., Schmidt S.D., Yang Z.Y., Bonsignori M., Crump J.A., Kapiga S.H., Sam N.E., Haynes B.F., Burton D.R., Koff W.C., Walker L.M., Phogat S., Wyatt R., Orwenyo J., Wang L.X., Arthos J., Bewley C.A., Mascola J.R., Nabel G.J., Schief W.R., Ward A.B., Wilson I.A., Kwong P.D. Nature 480:336-343(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 125-190.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ435682 Genomic DNA. Translation: ABE02700.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3U4E	X-ray	2.18	G/J	125-190	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.170.40.20. 2 hits.

InterPro

IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]

Pfam

PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]

SUPFAM

SSF56502. GP120. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q1PHM9_9HIV1

Accession

Primary (citable) accession number: Q1PHM9

Entry history

Integrated into UniProtKB/TrEMBL:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	March 6, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)