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Protein

Serine carboxypeptidase-like 22

Gene

SCPL22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable carboxypeptidase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791By similarity
Active sitei385 – 3851By similarity
Active sitei437 – 4371By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciARA:AT2G24000-MONOMER.
ARA:GQT-1707-MONOMER.

Protein family/group databases

ESTHERiarath-SCP22. Carboxypeptidase_S10.
MEROPSiS10.A35.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase-like 22 (EC:3.4.16.-)
Gene namesi
Name:SCPL22
Ordered Locus Names:At2g24000
ORF Names:T29E15.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G24000.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 464442Serine carboxypeptidase-like 22PRO_0000274638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi86 ↔ 346By similarity
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi247 ↔ 258By similarity
Disulfide bondi282 ↔ 314By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ1PF08.
PRIDEiQ1PF08.

Expressioni

Tissue specificityi

Expression not detected.1 Publication

Gene expression databases

ExpressionAtlasiQ1PF08. differential.
GenevisibleiQ1PF08. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G24000.1.

Structurei

3D structure databases

ProteinModelPortaliQ1PF08.
SMRiQ1PF08. Positions 25-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198295.
InParanoidiQ1PF08.
KOiK16297.
OMAiRAMHANH.
OrthoDBiEOG09360880.
PhylomeDBiQ1PF08.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1PF08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARTHLLFLL FVLLSLATSS TSTKEQEEDR IKALPGQPKV GFSQFSGYVT
60 70 80 90 100
VNESHGRSLF YWLTESSSHS PHTKPLLLWL NGGPGCSSIA YGASEEIGPF
110 120 130 140 150
RISKTGCNLY LNNFSWNTEA NLLFLESPVG VGFSYTNTSS DFEESGDERT
160 170 180 190 200
AQENLIFLIS WMSRFPQYRY RDFYIVGESY AGHYVPQLAQ KIHEYNNAYK
210 220 230 240 250
NPVINLKGFM VGNPEMDKNN DRLGTITYWW SHAMISDASY NRILKNCDFT
260 270 280 290 300
ADRFSKECDS AIYVAAADFG DIDQYSIYTP KCVPPQDQTN QTKFEQMMQM
310 320 330 340 350
HTTKRFLEDQ YDPCTENYAE IYYNRPEVQR AMHANHTAIP YKWTACSDSV
360 370 380 390 400
FNNWNWRDSD NSMLPIYKEL IAAGLRIWVY SGDTDSVIPV TATRYSLGKL
410 420 430 440 450
NLRVKTRWYP WYSGNQVGGR TEVYEGLTFV TVRGAGHEVP FFQPQSALIL
460
LRSFLAGNEL SRSY
Length:464
Mass (Da):53,106
Last modified:May 16, 2006 - v1
Checksum:iDFACB79F8A5BE6E4
GO
Isoform 2 (identifier: Q1PF08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-181: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):45,779
Checksum:i0D6810857CE3F90F
GO

Sequence cautioni

The sequence AAC63668 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 18163Missing in isoform 2. 1 PublicationVSP_022849Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005170 Genomic DNA. Translation: AAC63668.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07515.1.
CP002685 Genomic DNA. Translation: AEC07516.1.
DQ446557 mRNA. Translation: ABE65855.1.
DQ446558 mRNA. Translation: ABE65856.1.
PIRiD84631.
RefSeqiNP_001077950.1. NM_001084481.1. [Q1PF08-2]
NP_179978.2. NM_127962.2. [Q1PF08-1]
UniGeneiAt.52887.

Genome annotation databases

EnsemblPlantsiAT2G24000.1; AT2G24000.1; AT2G24000. [Q1PF08-1]
GeneIDi816934.
KEGGiath:AT2G24000.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005170 Genomic DNA. Translation: AAC63668.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07515.1.
CP002685 Genomic DNA. Translation: AEC07516.1.
DQ446557 mRNA. Translation: ABE65855.1.
DQ446558 mRNA. Translation: ABE65856.1.
PIRiD84631.
RefSeqiNP_001077950.1. NM_001084481.1. [Q1PF08-2]
NP_179978.2. NM_127962.2. [Q1PF08-1]
UniGeneiAt.52887.

3D structure databases

ProteinModelPortaliQ1PF08.
SMRiQ1PF08. Positions 25-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G24000.1.

Protein family/group databases

ESTHERiarath-SCP22. Carboxypeptidase_S10.
MEROPSiS10.A35.

Proteomic databases

PaxDbiQ1PF08.
PRIDEiQ1PF08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G24000.1; AT2G24000.1; AT2G24000. [Q1PF08-1]
GeneIDi816934.
KEGGiath:AT2G24000.

Organism-specific databases

TAIRiAT2G24000.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198295.
InParanoidiQ1PF08.
KOiK16297.
OMAiRAMHANH.
OrthoDBiEOG09360880.
PhylomeDBiQ1PF08.

Enzyme and pathway databases

BioCyciARA:AT2G24000-MONOMER.
ARA:GQT-1707-MONOMER.

Miscellaneous databases

PROiQ1PF08.

Gene expression databases

ExpressionAtlasiQ1PF08. differential.
GenevisibleiQ1PF08. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCP22_ARATH
AccessioniPrimary (citable) accession number: Q1PF08
Secondary accession number(s): O82228, Q1PF09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.