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Protein

Serine carboxypeptidase-like 22

Gene

SCPL22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable carboxypeptidase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179By similarity1
Active sitei385By similarity1
Active sitei437By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.

Protein family/group databases

ESTHERiarath-SCP22. Carboxypeptidase_S10.
MEROPSiS10.A35.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase-like 22 (EC:3.4.16.-)
Gene namesi
Name:SCPL22
Ordered Locus Names:At2g24000
ORF Names:T29E15.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G24000.
TAIRilocus:2061436. AT2G24000.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000027463823 – 464Serine carboxypeptidase-like 22Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 346By similarity
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi247 ↔ 258By similarity
Disulfide bondi282 ↔ 314By similarity
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ1PF08.

Expressioni

Tissue specificityi

Expression not detected.1 Publication

Gene expression databases

ExpressionAtlasiQ1PF08. baseline and differential.
GenevisibleiQ1PF08. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G24000.1.

Structurei

3D structure databases

ProteinModelPortaliQ1PF08.
SMRiQ1PF08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198295.
InParanoidiQ1PF08.
KOiK16297.
OMAiRAMHANH.
OrthoDBiEOG09360880.
PhylomeDBiQ1PF08.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1PF08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARTHLLFLL FVLLSLATSS TSTKEQEEDR IKALPGQPKV GFSQFSGYVT
60 70 80 90 100
VNESHGRSLF YWLTESSSHS PHTKPLLLWL NGGPGCSSIA YGASEEIGPF
110 120 130 140 150
RISKTGCNLY LNNFSWNTEA NLLFLESPVG VGFSYTNTSS DFEESGDERT
160 170 180 190 200
AQENLIFLIS WMSRFPQYRY RDFYIVGESY AGHYVPQLAQ KIHEYNNAYK
210 220 230 240 250
NPVINLKGFM VGNPEMDKNN DRLGTITYWW SHAMISDASY NRILKNCDFT
260 270 280 290 300
ADRFSKECDS AIYVAAADFG DIDQYSIYTP KCVPPQDQTN QTKFEQMMQM
310 320 330 340 350
HTTKRFLEDQ YDPCTENYAE IYYNRPEVQR AMHANHTAIP YKWTACSDSV
360 370 380 390 400
FNNWNWRDSD NSMLPIYKEL IAAGLRIWVY SGDTDSVIPV TATRYSLGKL
410 420 430 440 450
NLRVKTRWYP WYSGNQVGGR TEVYEGLTFV TVRGAGHEVP FFQPQSALIL
460
LRSFLAGNEL SRSY
Length:464
Mass (Da):53,106
Last modified:May 16, 2006 - v1
Checksum:iDFACB79F8A5BE6E4
GO
Isoform 2 (identifier: Q1PF08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-181: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):45,779
Checksum:i0D6810857CE3F90F
GO

Sequence cautioni

The sequence AAC63668 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022849119 – 181Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005170 Genomic DNA. Translation: AAC63668.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07515.1.
CP002685 Genomic DNA. Translation: AEC07516.1.
DQ446557 mRNA. Translation: ABE65855.1.
DQ446558 mRNA. Translation: ABE65856.1.
PIRiD84631.
RefSeqiNP_001077950.1. NM_001084481.1. [Q1PF08-2]
NP_179978.2. NM_127962.3. [Q1PF08-1]
UniGeneiAt.52887.

Genome annotation databases

EnsemblPlantsiAT2G24000.1; AT2G24000.1; AT2G24000. [Q1PF08-1]
AT2G24000.2; AT2G24000.2; AT2G24000. [Q1PF08-2]
GeneIDi816934.
GrameneiAT2G24000.1; AT2G24000.1; AT2G24000.
AT2G24000.2; AT2G24000.2; AT2G24000.
KEGGiath:AT2G24000.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSCP22_ARATH
AccessioniPrimary (citable) accession number: Q1PF08
Secondary accession number(s): O82228, Q1PF09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2006
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families