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Protein

Phosphatidate cytidylyltransferase 3

Gene

CDS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.1 Publication

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.1 Publication

Cofactori

Mg2+By similarityNote: Requires a divalent cation for activity.By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.1 Publication
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable glycerol-3-phosphate acyltransferase 2 (GPAT2), Glycerol-3-phosphate acyltransferase, chloroplastic (ATS1), Glycerol-3-phosphate acyltransferase 1 (GPAT1), Probable glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase 7 (GPAT7), Probable glycerol-3-phosphate acyltransferase 8 (GPAT8), Glycerol-3-phosphate acyltransferase 5 (GPAT5)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 (LPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (LPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase 1, chloroplastic (LPAT1), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5 (LPAT5), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4 (LPAT4)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 3 (CDS3), Phosphatidate cytidylyltransferase 4, chloroplastic (CDS4), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase 5, chloroplastic (CDS5), Phosphatidate cytidylyltransferase (CDS2), Phosphatidate cytidylyltransferase (CDS2)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • phosphatidate cytidylyltransferase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-ATH-1483148. Synthesis of PG.
R-ATH-1483226. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 31 Publication (EC:2.7.7.411 Publication)
Alternative name(s):
CDP-DAG synthase 3
CDP-DG synthase 3
CDP-diacylglycerol synthase 3
Short name:
CDS3
CDP-diglyceride pyrophosphorylase 3
CDP-diglyceride synthase 3
CTP:phosphatidate cytidylyltransferase 3
Gene namesi
Name:CDS31 Publication
Ordered Locus Names:At4g26770Imported
ORF Names:F10M23.110Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G26770.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11620Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei120 – 13920Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei255 – 27723Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei293 – 31321Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei368 – 38821Helical; Name=8Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Phosphatidate cytidylyltransferase 3PRO_0000431832Add
BLAST

Proteomic databases

PaxDbiQ1PE48.
PRIDEiQ1PE48.

PTM databases

iPTMnetiQ1PE48.

Expressioni

Gene expression databases

GenevisibleiQ1PE48. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G26770.1.

Structurei

3D structure databases

ProteinModelPortaliQ1PE48.
SMRiQ1PE48. Positions 204-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
HOGENOMiHOG000209582.
KOiK00981.
OMAiQRVAHEP.
OrthoDBiEOG093607DA.
PhylomeDBiQ1PE48.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1PE48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMEKDLSPN SPRIRKLRDT SYPTTPTSRM NTNNQRDNHY PNIPNSPRDY
60 70 80 90 100
NYTPSSPTAR IRHRRRSSEN LAEVNRSNVS RVSNLLLGDK NKYRSMWIRT
110 120 130 140 150
CSSLWMLGGV VFIIYMGHLY IWAMVVVIQI FMAKELFFLR RRAHEERRLP
160 170 180 190 200
GFWLLNWHFF FTAMLFVYGR IIQQQLVNTV SSDRFIYKLV SGLIKYQMVI
210 220 230 240 250
CYFLYIAGLI WFILTLKNKM YKYQFGQYAW THMILIVVFT QSSFTVANIF
260 270 280 290 300
EGIFWFLLPA ALIAMNDVAA YFFGFYFGKT PLIKLSPKKT WEGFIGASVA
310 320 330 340 350
TIISAFIFAN VLGQFQWLTC PRKDLSTGWL HCDPGPLFRP EYYPFPSWIT
360 370 380 390 400
PFSPWKGIST LPVQWHAFSL GLFASIMAPF GGFFASGFKR AFKIKDFGDS
410 420 430 440 450
IPGHGGFTDR MDCQMVMAVF AYIYIQSFIV NRDYSVEMIL DQISRSLGHE
460 470
EQKMLYEKLG DILQHKLQGR F
Length:471
Mass (Da):54,924
Last modified:May 16, 2006 - v1
Checksum:iFE217D1D047CB807
GO

Sequence cautioni

The sequence ABK28650 differs from that shown. Reason: Erroneous termination at position 472. Translated as stop.Curated
The sequence CAB36523 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB79532 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251L → F in CAB36523 (PubMed:10617198).Curated
Sequence conflicti325 – 3251L → F in CAB79532 (PubMed:10617198).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035440 Genomic DNA. Translation: CAB36523.1. Sequence problems.
AL161565 Genomic DNA. Translation: CAB79532.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE85250.1.
DQ446870 mRNA. Translation: ABE66091.1.
DQ653225 mRNA. Translation: ABK28650.1. Sequence problems.
PIRiT04800.
RefSeqiNP_194407.5. NM_118811.6.
UniGeneiAt.2590.
At.50368.

Genome annotation databases

EnsemblPlantsiAT4G26770.1; AT4G26770.1; AT4G26770.
GeneIDi828784.
GrameneiAT4G26770.1; AT4G26770.1; AT4G26770.
KEGGiath:AT4G26770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035440 Genomic DNA. Translation: CAB36523.1. Sequence problems.
AL161565 Genomic DNA. Translation: CAB79532.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE85250.1.
DQ446870 mRNA. Translation: ABE66091.1.
DQ653225 mRNA. Translation: ABK28650.1. Sequence problems.
PIRiT04800.
RefSeqiNP_194407.5. NM_118811.6.
UniGeneiAt.2590.
At.50368.

3D structure databases

ProteinModelPortaliQ1PE48.
SMRiQ1PE48. Positions 204-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G26770.1.

PTM databases

iPTMnetiQ1PE48.

Proteomic databases

PaxDbiQ1PE48.
PRIDEiQ1PE48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G26770.1; AT4G26770.1; AT4G26770.
GeneIDi828784.
GrameneiAT4G26770.1; AT4G26770.1; AT4G26770.
KEGGiath:AT4G26770.

Organism-specific databases

TAIRiAT4G26770.

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
HOGENOMiHOG000209582.
KOiK00981.
OMAiQRVAHEP.
OrthoDBiEOG093607DA.
PhylomeDBiQ1PE48.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
ReactomeiR-ATH-1483148. Synthesis of PG.
R-ATH-1483226. Synthesis of PI.

Miscellaneous databases

PROiQ1PE48.

Gene expression databases

GenevisibleiQ1PE48. AT.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDS3_ARATH
AccessioniPrimary (citable) accession number: Q1PE48
Secondary accession number(s): A0MF99, Q9SZ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.