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Protein

Diacylglycerol kinase 4

Gene

DGK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Plant defense, Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G57690-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase 4 (EC:2.7.1.107)
Short name:
AtDGK4
Short name:
DAG kinase 4
Alternative name(s):
Diglyceride kinase 4
Short name:
DGK 4
Gene namesi
Name:DGK4
Ordered Locus Names:At5g57690
ORF Names:MRI1.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G57690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Diacylglycerol kinase 4PRO_0000422112Add
BLAST

Proteomic databases

PaxDbiQ1PDI2.
PRIDEiQ1PDI2.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G57690.1.

Structurei

3D structure databases

ProteinModelPortaliQ1PDI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 242157DAGKcPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG316419.
HOGENOMiHOG000239559.
InParanoidiQ1PDI2.
KOiK00901.
OMAiDECAKEI.
PhylomeDBiQ1PDI2.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016961. Diacylglycerol_kinase_pln.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
PIRSFiPIRSF030829. Diacylglycerol_kinase_pln. 1 hit.
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1PDI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPSIGDSL TARMIPRHSS LDSFGAMKVS LLVNLASIRV SKAELRQRVM
60 70 80 90 100
LPQYLRIAIR DCILRKDDSF DASSSVAPPL ENNALTPEVP LMVFVNPKSG
110 120 130 140 150
GRQGPLIKER LQNLISEEQV YDLTEVKPNE FIRYGLGCLE AFASRGDECA
160 170 180 190 200
KEIREKMRIV VAGGDGTVGW VLGCLGELNL QNRLPVPPVS IMPLGTGNDL
210 220 230 240 250
SRSFGWGGSF PFAWKSAIKR TLHRASVAPI SRLDSWNILI TMPSGEIVDP
260 270 280 290 300
PYSLKATQEC YIDQNLEIEG EIPPSTNGYE GVFYNYFSIG MDAQVAYGFH
310 320 330 340 350
HLRNEKPYLA NGPIANKIIY SGYGCSQGWF LTHCINDPGL RGLKNIMTLH
360 370 380 390 400
IKKLDSSEWE KVPVPKSVRA VVALNLHSYG SGRNPWGNLK QDYLEKRGFV
410 420 430 440 450
EAQADDGLLE IFGLKQGWHA SFVMVELISA KHIAQAAAIR LEIRGGDWKD
460 470 480
AFMQMDGEPW KQPMTRDYST FVDIKRVPHQ SLVVKGD
Length:487
Mass (Da):54,181
Last modified:May 16, 2006 - v1
Checksum:i854450C00B8CE355
GO

Sequence cautioni

The sequence BAB09587.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018118 Genomic DNA. Translation: BAB09587.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED96936.1.
DQ447086 mRNA. Translation: ABE66256.1.
RefSeqiNP_200577.2. NM_125152.2.
UniGeneiAt.55605.

Genome annotation databases

EnsemblPlantsiAT5G57690.1; AT5G57690.1; AT5G57690.
GeneIDi835876.
KEGGiath:AT5G57690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018118 Genomic DNA. Translation: BAB09587.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED96936.1.
DQ447086 mRNA. Translation: ABE66256.1.
RefSeqiNP_200577.2. NM_125152.2.
UniGeneiAt.55605.

3D structure databases

ProteinModelPortaliQ1PDI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G57690.1.

Proteomic databases

PaxDbiQ1PDI2.
PRIDEiQ1PDI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G57690.1; AT5G57690.1; AT5G57690.
GeneIDi835876.
KEGGiath:AT5G57690.

Organism-specific databases

TAIRiAT5G57690.

Phylogenomic databases

eggNOGiNOG316419.
HOGENOMiHOG000239559.
InParanoidiQ1PDI2.
KOiK00901.
OMAiDECAKEI.
PhylomeDBiQ1PDI2.

Enzyme and pathway databases

BioCyciARA:AT5G57690-MONOMER.

Miscellaneous databases

PROiQ1PDI2.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016961. Diacylglycerol_kinase_pln.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
PIRSFiPIRSF030829. Diacylglycerol_kinase_pln. 1 hit.
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H., Miyajima N., Tabata S.
    DNA Res. 6:183-195(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiDGK4_ARATH
AccessioniPrimary (citable) accession number: Q1PDI2
Secondary accession number(s): Q9FHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 16, 2006
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.