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Q1PDH6

- LAC16_ARATH

UniProt

Q1PDH6 - LAC16_ARATH

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Protein

Laccase-16

Gene
LAC16, At5g58910, K19M22.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Copper 1; type 2 By similarity
Metal bindingi86 – 861Copper 2; type 3 By similarity
Metal bindingi129 – 1291Copper 2; type 3 By similarity
Metal bindingi131 – 1311Copper 3; type 3 By similarity
Metal bindingi467 – 4671Copper 4; type 1 By similarity
Metal bindingi470 – 4701Copper 1; type 2 By similarity
Metal bindingi472 – 4721Copper 3; type 3 By similarity
Metal bindingi529 – 5291Copper 3; type 3 By similarity
Metal bindingi530 – 5301Copper 4; type 1 By similarity
Metal bindingi531 – 5311Copper 2; type 3 By similarity
Metal bindingi535 – 5351Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G58910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-16 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 16
Diphenol oxidase 16
Urishiol oxidase 16
Gene namesi
Name:LAC16
Ordered Locus Names:At5g58910
ORF Names:K19M22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G58910.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 566539Laccase-16PRO_0000283644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi389 – 3891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi449 – 4491N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Mostly expressed in roots at low level.2 Publications

Gene expression databases

GenevestigatoriQ1PDH6.

Structurei

3D structure databases

ProteinModelPortaliQ1PDH6.
SMRiQ1PDH6. Positions 46-545.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 150114Plastocyanin-like 1Add
BLAST
Domaini160 – 312153Plastocyanin-like 2Add
BLAST
Domaini414 – 550137Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ1PDH6.
PhylomeDBiQ1PDH6.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1PDH6-1 [UniParc]FASTAAdd to Basket

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MEIPRRFCIC VLTFFVFVLL SPTTVHSIIR HYKFNVMTNT TKLCSSKPIV    50
TVNGQFPGPT IVAREGDTIL IKVVNHVKYN VSIHWHGIRQ LRTGWADGPA 100
YITQCPIQPG QNYLHNFTLT GQRGTLWWHA HILWLRATVH GAIVILPKLG 150
VPYPFPKPYK EKTIVLSEWW KSDVEELINE ASRIGTAPSA SDAHTINGHS 200
GSISNCPSQS SYGLPVRAGK TYMLRIINAA LNEELFFKIA GHVLTVVEVD 250
AVYTKPYKTD TVFIAPGQTT NVLLTANANA GSNYMVAATT FTDAHIPYDN 300
VTATATLHYI GHTSTVSTSK KTVLASLPPQ NATWVATKFT RSLRSLNSLE 350
YPARVPTTVE HSLFFTVGLG ANPCQSCNNG VRLVAGINNV TFTMPKTALL 400
QAHFFNISGV FTDDFPAKPS NPYDYTAPVK LGVNAATMKG TKLYRLPYNA 450
TVQIVLQNTA MILSDNHPFH LHGFNFFEVG RGLGNFNPEK DPKAFNLVDP 500
VERNTVGVPA GGWTAIRFIA DNPGVWFMHC HLELHTTWGL KMAFVVDNGH 550
GPDQSLLPPP ADLPKC 566
Length:566
Mass (Da):62,373
Last modified:April 3, 2007 - v2
Checksum:i4BCFEEC24628B5FB
GO

Sequence cautioni

The sequence ABK28766.1 differs from that shown. Reason: Erroneous termination at position 567. Translated as stop.
The sequence AED97116.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016885 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED97116.1. Sequence problems.
DQ447092 mRNA. Translation: ABE66261.1.
DQ653381 mRNA. Translation: ABK28766.1. Sequence problems.
RefSeqiNP_200699.1. NM_125281.1.
UniGeneiAt.55619.

Genome annotation databases

EnsemblPlantsiAT5G58910.1; AT5G58910.1; AT5G58910.
GeneIDi836008.
KEGGiath:AT5G58910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016885 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED97116.1 . Sequence problems.
DQ447092 mRNA. Translation: ABE66261.1 .
DQ653381 mRNA. Translation: ABK28766.1 . Sequence problems.
RefSeqi NP_200699.1. NM_125281.1.
UniGenei At.55619.

3D structure databases

ProteinModelPortali Q1PDH6.
SMRi Q1PDH6. Positions 46-545.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G58910.1 ; AT5G58910.1 ; AT5G58910 .
GeneIDi 836008.
KEGGi ath:AT5G58910.

Organism-specific databases

TAIRi AT5G58910.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q1PDH6.
PhylomeDBi Q1PDH6.

Enzyme and pathway databases

BioCyci ARA:AT5G58910-MONOMER.

Gene expression databases

Genevestigatori Q1PDH6.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
    Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-566.
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC16_ARATH
AccessioniPrimary (citable) accession number: Q1PDH6
Secondary accession number(s): A0MFQ5, F4KGE3, Q3E893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi