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Reviewed, UniProtKB/Swiss-Prot Q1PDH6 (LAC16_ARATH)

Last modified November 25, 2008. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-16
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 16
    Urishiol oxidase 16
    Diphenol oxidase 16
Gene names
Name: LAC16
Ordered Locus Names: At5g58910
ORF Names: K19M22.11
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activity

4 benzenediol + O(2) = 4 benzosemiquinone + 2 H(2)O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Tissue specificity

Mostly expressed in roots at low level.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Sequence caution

The sequence ABK28766.1 differs from that shown. Reason: Erroneous termination at position 567. Translated as stop.

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Ontologies

Keywords

   Biological processLignin degradation
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 566539Laccase-16
PRO_0000283644

Regions

Domain37 – 150114Plastocyanin-like 1
Domain160 – 312153Plastocyanin-like 2
Domain414 – 550137Plastocyanin-like 3

Sites

Metal binding841Copper 1; type 2 By similarity
Metal binding861Copper 2; type 3 By similarity
Metal binding1291Copper 2; type 3 By similarity
Metal binding1311Copper 3; type 3 By similarity
Metal binding4671Copper 4; type 1 By similarity
Metal binding4701Copper 1; type 2 By similarity
Metal binding4721Copper 3; type 3 By similarity
Metal binding5291Copper 3; type 3 By similarity
Metal binding5301Copper 4; type 1 By similarity
Metal binding5311Copper 2; type 3 By similarity
Metal binding5351Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q1PDH6-1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 4BCFEEC24628B5FB

FASTA56662,373
        10         20         30         40         50         60 
MEIPRRFCIC VLTFFVFVLL SPTTVHSIIR HYKFNVMTNT TKLCSSKPIV TVNGQFPGPT 

        70         80         90        100        110        120 
IVAREGDTIL IKVVNHVKYN VSIHWHGIRQ LRTGWADGPA YITQCPIQPG QNYLHNFTLT 

       130        140        150        160        170        180 
GQRGTLWWHA HILWLRATVH GAIVILPKLG VPYPFPKPYK EKTIVLSEWW KSDVEELINE 

       190        200        210        220        230        240 
ASRIGTAPSA SDAHTINGHS GSISNCPSQS SYGLPVRAGK TYMLRIINAA LNEELFFKIA 

       250        260        270        280        290        300 
GHVLTVVEVD AVYTKPYKTD TVFIAPGQTT NVLLTANANA GSNYMVAATT FTDAHIPYDN 

       310        320        330        340        350        360 
VTATATLHYI GHTSTVSTSK KTVLASLPPQ NATWVATKFT RSLRSLNSLE YPARVPTTVE 

       370        380        390        400        410        420 
HSLFFTVGLG ANPCQSCNNG VRLVAGINNV TFTMPKTALL QAHFFNISGV FTDDFPAKPS 

       430        440        450        460        470        480 
NPYDYTAPVK LGVNAATMKG TKLYRLPYNA TVQIVLQNTA MILSDNHPFH LHGFNFFEVG 

       490        500        510        520        530        540 
RGLGNFNPEK DPKAFNLVDP VERNTVGVPA GGWTAIRFIA DNPGVWFMHC HLELHTTWGL 

       550        560 
KMAFVVDNGH GPDQSLLPPP ADLPKC

« Hide

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References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
DNA Res. 5:379-391(1998) [PubMed: 10048488] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
Plant Biotechnol. J. 4:317-324(2006) [PubMed: 17147637] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-566.
Strain: cv. Columbia.
[3]"Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
McCaig B.C., Meagher R.B., Dean J.F.D.
Planta 221:619-636(2005) [PubMed: 15940465] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"Mutant identification and characterization of the laccase gene family in Arabidopsis."
Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
J. Exp. Bot. 57:2563-2569(2006) [PubMed: 16804053] [Abstract]
Cited for: TISSUE SPECIFICITY.

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Cross-references

Sequence databases

AB016885 Genomic DNA. No translation available.
DQ447092 mRNA. Translation: ABE66261.1.
DQ653381 mRNA. Translation: ABK28766.1. Sequence problems.

3D structure databases

ModBaseSearch...

Genome annotation databases

GenomeReviewsGene locus AT5G58910 in contig BA000015_GR.

Organism-specific databases

TAIRAt5g58910.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC16_ARATH
AccessionPrimary (citable) accession number: Q1PDH6
Secondary accession number(s): A0MFQ5, Q3E893
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 25, 2008
This is version 20 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents