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Protein

Laccase-16

Gene

LAC16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1; type 2By similarity1
Metal bindingi86Copper 2; type 3By similarity1
Metal bindingi129Copper 2; type 3By similarity1
Metal bindingi131Copper 3; type 3By similarity1
Metal bindingi467Copper 4; type 1By similarity1
Metal bindingi470Copper 1; type 2By similarity1
Metal bindingi472Copper 3; type 3By similarity1
Metal bindingi529Copper 3; type 3By similarity1
Metal bindingi530Copper 4; type 1By similarity1
Metal bindingi531Copper 2; type 3By similarity1
Metal bindingi535Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-16 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 16
Diphenol oxidase 16
Urishiol oxidase 16
Gene namesi
Name:LAC16
Ordered Locus Names:At5g58910
ORF Names:K19M22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G58910
TAIRilocus:2154518 AT5G58910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000028364428 – 566Laccase-16Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1PDH6

Expressioni

Tissue specificityi

Mostly expressed in roots at low level.2 Publications

Gene expression databases

ExpressionAtlasiQ1PDH6 baseline and differential
GenevisibleiQ1PDH6 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G58910.1

Structurei

3D structure databases

ProteinModelPortaliQ1PDH6
SMRiQ1PDH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 150Plastocyanin-like 1Add BLAST114
Domaini160 – 312Plastocyanin-like 2Add BLAST153
Domaini414 – 550Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ1PDH6
KOiK05909
OrthoDBiEOG093605NS
PhylomeDBiQ1PDH6

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 4 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1PDH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPRRFCIC VLTFFVFVLL SPTTVHSIIR HYKFNVMTNT TKLCSSKPIV
60 70 80 90 100
TVNGQFPGPT IVAREGDTIL IKVVNHVKYN VSIHWHGIRQ LRTGWADGPA
110 120 130 140 150
YITQCPIQPG QNYLHNFTLT GQRGTLWWHA HILWLRATVH GAIVILPKLG
160 170 180 190 200
VPYPFPKPYK EKTIVLSEWW KSDVEELINE ASRIGTAPSA SDAHTINGHS
210 220 230 240 250
GSISNCPSQS SYGLPVRAGK TYMLRIINAA LNEELFFKIA GHVLTVVEVD
260 270 280 290 300
AVYTKPYKTD TVFIAPGQTT NVLLTANANA GSNYMVAATT FTDAHIPYDN
310 320 330 340 350
VTATATLHYI GHTSTVSTSK KTVLASLPPQ NATWVATKFT RSLRSLNSLE
360 370 380 390 400
YPARVPTTVE HSLFFTVGLG ANPCQSCNNG VRLVAGINNV TFTMPKTALL
410 420 430 440 450
QAHFFNISGV FTDDFPAKPS NPYDYTAPVK LGVNAATMKG TKLYRLPYNA
460 470 480 490 500
TVQIVLQNTA MILSDNHPFH LHGFNFFEVG RGLGNFNPEK DPKAFNLVDP
510 520 530 540 550
VERNTVGVPA GGWTAIRFIA DNPGVWFMHC HLELHTTWGL KMAFVVDNGH
560
GPDQSLLPPP ADLPKC
Length:566
Mass (Da):62,373
Last modified:April 3, 2007 - v2
Checksum:i4BCFEEC24628B5FB
GO

Sequence cautioni

The sequence ABK28766 differs from that shown. Reason: Erroneous termination at position 567. Translated as stop.Curated
The sequence AED97116 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016885 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED97116.1 Sequence problems.
CP002688 Genomic DNA Translation: ANM68673.1
DQ447092 mRNA Translation: ABE66261.1
DQ653381 mRNA Translation: ABK28766.1 Sequence problems.
RefSeqiNP_001330401.1, NM_001345329.1
NP_200699.1, NM_125281.1
UniGeneiAt.55619

Genome annotation databases

EnsemblPlantsiAT5G58910.3; AT5G58910.3; AT5G58910
GeneIDi836008
GrameneiAT5G58910.3; AT5G58910.3; AT5G58910
KEGGiath:AT5G58910

Similar proteinsi

Entry informationi

Entry nameiLAC16_ARATH
AccessioniPrimary (citable) accession number: Q1PDH6
Secondary accession number(s): A0MFQ5, F4KGE3, Q3E893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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