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Q1PDH6

- LAC16_ARATH

UniProt

Q1PDH6 - LAC16_ARATH

Protein

Laccase-16

Gene

LAC16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Copper 1; type 2By similarity
    Metal bindingi86 – 861Copper 2; type 3By similarity
    Metal bindingi129 – 1291Copper 2; type 3By similarity
    Metal bindingi131 – 1311Copper 3; type 3By similarity
    Metal bindingi467 – 4671Copper 4; type 1By similarity
    Metal bindingi470 – 4701Copper 1; type 2By similarity
    Metal bindingi472 – 4721Copper 3; type 3By similarity
    Metal bindingi529 – 5291Copper 3; type 3By similarity
    Metal bindingi530 – 5301Copper 4; type 1By similarity
    Metal bindingi531 – 5311Copper 2; type 3By similarity
    Metal bindingi535 – 5351Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G58910-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-16 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 16
    Diphenol oxidase 16
    Urishiol oxidase 16
    Gene namesi
    Name:LAC16
    Ordered Locus Names:At5g58910
    ORF Names:K19M22.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G58910.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 566539Laccase-16PRO_0000283644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Mostly expressed in roots at low level.2 Publications

    Gene expression databases

    GenevestigatoriQ1PDH6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1PDH6.
    SMRiQ1PDH6. Positions 46-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 150114Plastocyanin-like 1Add
    BLAST
    Domaini160 – 312153Plastocyanin-like 2Add
    BLAST
    Domaini414 – 550137Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ1PDH6.
    PhylomeDBiQ1PDH6.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 4 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1PDH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIPRRFCIC VLTFFVFVLL SPTTVHSIIR HYKFNVMTNT TKLCSSKPIV    50
    TVNGQFPGPT IVAREGDTIL IKVVNHVKYN VSIHWHGIRQ LRTGWADGPA 100
    YITQCPIQPG QNYLHNFTLT GQRGTLWWHA HILWLRATVH GAIVILPKLG 150
    VPYPFPKPYK EKTIVLSEWW KSDVEELINE ASRIGTAPSA SDAHTINGHS 200
    GSISNCPSQS SYGLPVRAGK TYMLRIINAA LNEELFFKIA GHVLTVVEVD 250
    AVYTKPYKTD TVFIAPGQTT NVLLTANANA GSNYMVAATT FTDAHIPYDN 300
    VTATATLHYI GHTSTVSTSK KTVLASLPPQ NATWVATKFT RSLRSLNSLE 350
    YPARVPTTVE HSLFFTVGLG ANPCQSCNNG VRLVAGINNV TFTMPKTALL 400
    QAHFFNISGV FTDDFPAKPS NPYDYTAPVK LGVNAATMKG TKLYRLPYNA 450
    TVQIVLQNTA MILSDNHPFH LHGFNFFEVG RGLGNFNPEK DPKAFNLVDP 500
    VERNTVGVPA GGWTAIRFIA DNPGVWFMHC HLELHTTWGL KMAFVVDNGH 550
    GPDQSLLPPP ADLPKC 566
    Length:566
    Mass (Da):62,373
    Last modified:April 3, 2007 - v2
    Checksum:i4BCFEEC24628B5FB
    GO

    Sequence cautioni

    The sequence ABK28766.1 differs from that shown. Reason: Erroneous termination at position 567. Translated as stop.
    The sequence AED97116.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016885 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED97116.1. Sequence problems.
    DQ447092 mRNA. Translation: ABE66261.1.
    DQ653381 mRNA. Translation: ABK28766.1. Sequence problems.
    RefSeqiNP_200699.1. NM_125281.1.
    UniGeneiAt.55619.

    Genome annotation databases

    EnsemblPlantsiAT5G58910.1; AT5G58910.1; AT5G58910.
    GeneIDi836008.
    KEGGiath:AT5G58910.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016885 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED97116.1 . Sequence problems.
    DQ447092 mRNA. Translation: ABE66261.1 .
    DQ653381 mRNA. Translation: ABK28766.1 . Sequence problems.
    RefSeqi NP_200699.1. NM_125281.1.
    UniGenei At.55619.

    3D structure databases

    ProteinModelPortali Q1PDH6.
    SMRi Q1PDH6. Positions 46-545.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G58910.1 ; AT5G58910.1 ; AT5G58910 .
    GeneIDi 836008.
    KEGGi ath:AT5G58910.

    Organism-specific databases

    TAIRi AT5G58910.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q1PDH6.
    PhylomeDBi Q1PDH6.

    Enzyme and pathway databases

    BioCyci ARA:AT5G58910-MONOMER.

    Gene expression databases

    Genevestigatori Q1PDH6.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 4 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
      Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
      DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-566.
      Strain: cv. Columbia.
    4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
      McCaig B.C., Meagher R.B., Dean J.F.D.
      Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC16_ARATH
    AccessioniPrimary (citable) accession number: Q1PDH6
    Secondary accession number(s): A0MFQ5, F4KGE3, Q3E893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3