Q1PDC5 (VP24_MABVR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-associated protein VP24

Gene names

Name:

VP24

Organism

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987)) [Complete proteome]

Taxonomic identifier

378809 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Mononegavirales › Filoviridae › Marburgvirus › Marburg marburgvirus

Virus host

Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Homo sapiens (Human) [TaxID: 9606]
Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) [TaxID: 9407]

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding By similarity.
Subunit structure	Monomer or homotetramer Potential. Interacts with the nucleoprotein By similarity.
Subcellular location	Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity. Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.
Sequence similarities	Belongs to the filoviridae membrane-associated protein VP24 family.

Ontologies

Keywords
Cellular component	Host cell membrane Host membrane Membrane Viral matrix protein Virion
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Membrane-associated protein VP24		PRO_0000314991

Sequences

	Sequence		Length	Mass (Da)
	Q1PDC5 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 81967AA4CC734AE0	FASTA	253	28,678
	10 20 30 40 50 60 MAELSTRYNL PTNITEKSIN LDLNSTARWV KEPSVGGWTV KWGNFIFHIP NTGMTLLHHL 70 80 90 100 110 120 KSNFVVPEWQ QTRSLFSHLF KNPKSTIMEP FLALRILLGV ALKDQELQQS LIPGFRSIVH 130 140 150 160 170 180 MLSEWLLLEV TSAIHISPNL LGIYLTSDMF KILMAGVKNF FNKLFTLHVV NDHGKPSSIE 190 200 210 220 230 240 IKLTGQQIII TRVNMGFLVE VRRIDIEPCC GETVLSESVV FGLVAEAVLR EHSQIERGQP 250 LNLTQYMNSK IAI

References

[1]

"Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola." Towner J.S., Khristova M.L., Sealy T.K., Vincent M.J., Erickson B.R., Bawiec D.A., Hartman A.L., Comer J.A., Zaki S.R., Stroeher U., Gomes da Silva F., del Castillo F., Rollin P.E., Ksiazek T.G., Nichol S.T. J. Virol. 80:6497-6516(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ447649 Genomic RNA. Translation: ABE27073.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009433. Filo_VP24. [Graphical view]
Pfam	PF06389. Filo_VP24. 1 hit. [Graphical view]
PIRSF	PIRSF011355. VP24. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VP24_MABVR

Accession

Primary (citable) accession number: Q1PDC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	May 16, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program