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Protein

Kinesin-like protein tea2

Gene

tea2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: PomBase
  • microtubule binding Source: UniProtKB

GO - Biological processi

  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • microtubule polymerization based protein transport to cell tip cortex Source: PomBase
  • protein transport along microtubule Source: PomBase
  • protein transport along microtubule to cell tip Source: PomBase

Keywordsi

Molecular functionHydrolase, Motor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein tea2
Alternative name(s):
Kinesin-like protein 4
Tip elongation aberrant protein 2
Gene namesi
Name:tea2Imported
Synonyms:klp4Imported
ORF Names:SPBC1604.20c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1604.20c.
PomBaseiSPBC1604.20c. tea2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex of cell tip Source: PomBase
  • cell tip Source: PomBase
  • cortical microtubule plus-end Source: PomBase
  • cytoplasm Source: PomBase
  • cytoplasmic microtubule Source: PomBase
  • cytoplasmic microtubule plus-end Source: PomBase
  • kinesin complex Source: GO_Central
  • microtubule end Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596081 – 628Kinesin-like protein tea2Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ1MTQ1.
PRIDEiQ1MTQ1.

PTM databases

iPTMnetiQ1MTQ1.

Interactioni

Subunit structurei

Interacts with mal3 and tip1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • microtubule binding Source: UniProtKB

Protein-protein interaction databases

BioGridi276404. 126 interactors.
DIPiDIP-35717N.
IntActiQ1MTQ1. 4 interactors.
STRINGi4896.SPBC1604.20c.1.

Structurei

3D structure databases

ProteinModelPortaliQ1MTQ1.
SMRiQ1MTQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 460Kinesin motorPROSITE-ProRule annotationAdd BLAST329

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 122Interaction with mal31 PublicationAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili530 – 557Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ1MTQ1.
KOiK11498.
OrthoDBiEOG092C2D4G.
PhylomeDBiQ1MTQ1.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MTQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSSSKPVN TGLVTPRRYS TMTGIRTGPS QSGTGSIPYS PTSPLSRNFS
60 70 80 90 100
NYSIPMLRSN STQTNVNGPT AFDLGVTEKL MSPGTLDRYT RPALYPSKDL
110 120 130 140 150
DYLKNEYVNY ESTTSQQTNS KGLKESNFVG SGIITSIRIR PIGKNQGVWS
160 170 180 190 200
HGKLSNDPYG REYIRQQTST SSSTIQQEYL FNNVFGMESK NYDIYKRSVK
210 220 230 240 250
SVVRNVFSGY NGIVFAYGMT GTGKTYSMQG TENEPGIIPL AMNDLFEMVE
260 270 280 290 300
NNSDDDTFQI RISYLEIYNE RIRDLIGNSD EEPRIRENAS GEVNVTPLTR
310 320 330 340 350
VLVTSPEEVS QVIEQCNAIR KTAATDFNTY SSRSHAILQV FLIRNNPTAH
360 370 380 390 400
TSQISSLSLV DLAGSERASA HHERRKEGAF INKSLLTLGT VISRLSAAAN
410 420 430 440 450
PSLTSNSGHI PYRESKLTRL LQQSLSGQSQ ISLLATISIE SNHTMETTNT
460 470 480 490 500
LKFASRAQNL PQDIRQAEAV TNVQAELASL HSALEKNAQE VEYYASLVKQ
510 520 530 540 550
LTSDLEERDT YIAMLEAERS QGTAISRARL RMEELLSDHN FEIADLRDEL
560 570 580 590 600
QDKEQIIYAL RYAQKQRDIA DFNQSLAKFP HKILKKNVTR GSRSSSDQFS
610 620
NETKTEILPD DQQQSKKDSV TQETQLLS
Length:628
Mass (Da):70,099
Last modified:May 30, 2006 - v1
Checksum:i0C108D4B9690A6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22353.1.
AB027903 Genomic DNA. Translation: BAA87207.1.
PIRiT39494.
RefSeqiNP_596620.1. NM_001022541.2.

Genome annotation databases

EnsemblFungiiSPBC1604.20c.1; SPBC1604.20c.1:pep; SPBC1604.20c.
GeneIDi2539857.
KEGGispo:SPBC1604.20c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTEA2_SCHPO
AccessioniPrimary (citable) accession number: Q1MTQ1
Secondary accession number(s): O94732
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 30, 2006
Last modified: July 5, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families