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Protein

Inner centromere protein-related protein pic1

Gene

pic1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for chromosome segregation and cytokinesis. Has a role in sister chromatid cohesion and condensation.1 Publication

GO - Biological processi

  • mitotic cytokinesis Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Inner centromere protein-related protein pic1
Short name:
INCENP-related protein pic1
Gene namesi
Name:pic1
ORF Names:SPBC336.15, SPBC685.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC336.15.
PomBaseiSPBC336.15. pic1.

Subcellular locationi

GO - Cellular componenti

  • chromosome passenger complex Source: PomBase
  • condensed nuclear chromosome inner kinetochore Source: PomBase
  • cytoplasm Source: UniProtKB-KW
  • mitotic spindle Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10181018Inner centromere protein-related protein pic1PRO_0000255436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ1MTN3.

PTM databases

iPTMnetiQ1MTN3.

Interactioni

Subunit structurei

Interacts with ark1.2 Publications

Protein-protein interaction databases

BioGridi276782. 6 interactions.
DIPiDIP-59225N.
MINTiMINT-4700178.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi269 – 34072Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the INCENP family.Curated

Phylogenomic databases

InParanoidiQ1MTN3.
OrthoDBiEOG77M8WZ.
PhylomeDBiQ1MTN3.

Family and domain databases

InterProiIPR005635. Inner_centromere_prot_ARK-bd.
[Graphical view]
PfamiPF03941. INCENP_ARK-bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MTN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNGSELWF NKELEYSQQL TNGKMKEFFF LVSETMDWLN EHMLEVSKLQ
60 70 80 90 100
LESDIYELVR TPTKIKEKYS TPRLSPVHRC ALPTPRMRLT SIQHQLEEAA
110 120 130 140 150
VEGYKSGESN TVKEPKELHT ATNTETQFDD DRDSTKLSSE YVKDDIVNKS
160 170 180 190 200
TKGGVSPIKE TRLPTNLPAF SPTSVERRFT EWNVPLRETS PSPSETADSP
210 220 230 240 250
NKLPKQKHPA YSFVTLPKRE EILKRPASLH SRVESTNSFI NQLNRRRTKD
260 270 280 290 300
NLTNNPEISL DEPIKALPST TSDAPSSLLN TNVSSSPSKF RKFLSSVIPA
310 320 330 340 350
KTDLSAKESL TSSTRLSTSY KTRKRSSGVA FSSETVTSSS KERKRSVENE
360 370 380 390 400
MLKPHPTIFE SPPEITSFDK SNAVEAEALT AKLKSNEERL PVSSQPGSDA
410 420 430 440 450
KSQEFDFFEA KIPDSIAKLN ELTASNENHY ELKTYDRAER LRQKIQEVSS
460 470 480 490 500
NKRLIPSTPP TKKPINAVLD AAKNSAAKDL HLAKMKLNNK NDESSLSPAK
510 520 530 540 550
SHAVITQAPK IPLISTFTRL STRKSSNDFN SSNSRPSSNA LKSDANENTD
560 570 580 590 600
SSLPPSKKEF IEKSLHKLSE PLHDDSRQNS DHNFAPHSRP IAIRVATASQ
610 620 630 640 650
RELEQTEKRK AKNGAANASN MESRSSENET HRFKKFYGKE RELSNNEFPS
660 670 680 690 700
RQTKTVTSAN SSNIRDMEHT ISDKPRSEPD AIPSSKSMHS NKPFEEKSEK
710 720 730 740 750
PTTKRLVTNP SNVNASWHSN MLKRQEDLRK KKPLTDNGAT SRHMLKSGLT
760 770 780 790 800
RVTSKPTQRF ANELAEDMSL AFHSTIPKKM EPDSVTSVTQ PSVGSLRNNF
810 820 830 840 850
DIGTTNSQNE DRKKKIAAQK NKNPVHGNVG LTNQHGFKTM HHNVNPFTKQ
860 870 880 890 900
NGIMKGKLPS SSTSQSNKPF IEKASMHAPA KGRNSSMQEP SSKSPLLKTP
910 920 930 940 950
KSNYFPGYGS LSPNTSVELP EINSDYSDDS DDEGNKKKVN LPSWAESPEL
960 970 980 990 1000
REQLKRQQKW DPDKIFGMIK PLQMDEYFRS KDRSKIRFRP RSSSADWSSQ
1010
DRLTQAEIDN YKKNMGFL
Length:1,018
Mass (Da):114,476
Last modified:October 31, 2006 - v2
Checksum:i510368FCD2E8098C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB58167.1.
PIRiT40253.
RefSeqiNP_596135.2. NM_001022053.2.

Genome annotation databases

EnsemblFungiiSPBC336.15.1; SPBC336.15.1:pep; SPBC336.15.
GeneIDi2540250.
KEGGispo:SPBC336.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB58167.1.
PIRiT40253.
RefSeqiNP_596135.2. NM_001022053.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276782. 6 interactions.
DIPiDIP-59225N.
MINTiMINT-4700178.

PTM databases

iPTMnetiQ1MTN3.

Proteomic databases

MaxQBiQ1MTN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC336.15.1; SPBC336.15.1:pep; SPBC336.15.
GeneIDi2540250.
KEGGispo:SPBC336.15.

Organism-specific databases

EuPathDBiFungiDB:SPBC336.15.
PomBaseiSPBC336.15. pic1.

Phylogenomic databases

InParanoidiQ1MTN3.
OrthoDBiEOG77M8WZ.
PhylomeDBiQ1MTN3.

Miscellaneous databases

NextBioi20801381.
PROiQ1MTN3.

Family and domain databases

InterProiIPR005635. Inner_centromere_prot_ARK-bd.
[Graphical view]
PfamiPF03941. INCENP_ARK-bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis."
    Leverson J.D., Huang H.-K., Forsburg S.L., Hunter T.
    Mol. Biol. Cell 13:1132-1143(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARK1.
  3. "Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation."
    Huang H.-K., Bailis J.M., Leverson J.D., Gomez E.B., Forsburg S.L., Hunter T.
    Mol. Cell. Biol. 25:9000-9015(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARK1, SUBCELLULAR LOCATION.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPIC1_SCHPO
AccessioniPrimary (citable) accession number: Q1MTN3
Secondary accession number(s): Q9UST0, Q9Y7L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 13, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.