ID   TPISA_DANRE             Reviewed;         248 AA.
AC   Q1MTI4; Q7ZWB0; Q90XF9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Triosephosphate isomerase A;
DE            Short=TIM-A;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase A;
GN   Name=tpi1a; ORFNames=si:dkey-89b17.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21518599; PubMed=11606544;
RA   Merritt T.J.S., Quattro J.M.;
RT   "Evidence for a period of directional selection following gene
RT   duplication in a neurally expressed locus of triosephosphate
RT   isomerase.";
RL   Genetics 159:689-697(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RG   The Danio rerio sequencing project at the Sanger Institute;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; AF387820; AAK85203.1; -; mRNA.
DR   EMBL; AL772314; CAK11229.1; -; Genomic_DNA.
DR   EMBL; BC049500; AAH49500.1; -; mRNA.
DR   IPI; IPI00498329; -.
DR   RefSeq; NP_705953.1; -.
DR   UniGene; Dr.82679; -.
DR   SMR; Q1MTI4; 4-247.
DR   Ensembl; ENSDARG00000025012; Danio rerio.
DR   GeneID; 192309; -.
DR   KEGG; dre:192309; -.
DR   NMPDR; fig|7955.3.peg.9678; -.
DR   ZFIN; ZDB-GENE-020416-3; tpi1a.
DR   HOVERGEN; Q1MTI4; -.
DR   OMA; Q1MTI4; PNCIFLY.
DR   ArrayExpress; Q1MTI4; -.
DR   Bgee; Q1MTI4; -.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid biosynthesis; Gluconeogenesis; Glycolysis; Isomerase;
KW   Lipid synthesis; Pentose shunt.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    248       Triosephosphate isomerase A.
FT                                /FTId=PRO_0000345140.
FT   ACT_SITE     95     95       Electrophile (By similarity).
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
FT   BINDING      13     13       Substrate (By similarity).
FT   CONFLICT     36     36       E -> K (in Ref. 1; AAK85203).
FT   CONFLICT    134    134       R -> K (in Ref. 2; AAH49500).
FT   CONFLICT    179    179       E -> G (in Ref. 2; AAH49500).
FT   CONFLICT    190    190       G -> E (in Ref. 1; AAK85203).
SQ   SEQUENCE   248 AA;  26853 MW;  546B461C6CBD1610 CRC64;
     MSSRKFFVGG NWKMNGDKES LGELIMTLNT ASLNDETDVV CGAPSIYLDY ARSKLDQRIG
     VAAQNCYKVP KGAFTGEISP AMIKDCGIDW VILGHSERRH VFGESDELIG QKVAHCLESD
     LGVIACIGEK LEEREAGTTE DVVFEQTKVI ADNVKDWTRV VLAYEPVWAI GTGKTASPEQ
     AQEVHEKLRG WLRANVSDAV ADSVRIIYGG SVTGGNCKEL AAQADVDGFL VGGASLKPEF
     VDIINARS
//