Q1MSW8 (Q1MSW8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cellular tumor antigen p53 RuleBase RU003304

Gene names

Name:

TP53 EMBL CAJ28923.1

Organism

Homo sapiens (Human) EMBL CAJ28923.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Binds DNA as a homotetramer By similarity.
Subcellular location	Cytoplasm. Nucleus By similarity.
Sequence similarities	Belongs to the p53 family. RuleBase RU003401

Ontologies

Keywords
Biological process	Apoptosis RuleBase RU003304 Cell cycle RuleBase RU003304 Transcription Transcription regulation SAAS SAAS012346 RuleBase RU003304
Cellular component	Cytoplasm RuleBase RU003304 Nucleus SAAS SAAS012346 RuleBase RU003304 RuleBase RU003401
Disease	Tumor suppressor RuleBase RU003304
Ligand	DNA-binding RuleBase RU003304 Metal-binding RuleBase RU003304 Zinc RuleBase RU003304
Molecular function	Activator RuleBase RU003304
PTM	Phosphoprotein RuleBase RU003304
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAJ28923.1
	Non-terminal residue	343	1	EMBL CAJ28923.1

Sequences

	Sequence		Length	Mass (Da)
	Q1MSW8 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: E063D90FB1019883	FASTA	343	37,993
	10 20 30 40 50 60 MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 70 80 90 100 110 120 DEAPRMPEAA PRVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 130 140 150 160 170 180 SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 190 200 210 220 230 240 RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 250 260 270 280 290 300 SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 310 320 330 340 PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QKTFPARHGG SHL

References

[1]	"Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma." Feuerborn A., Moritz C., von Bonin F., Dobbelstein M., Tromper M., Strzenhofecker B., Kube D. Leuk. Lymphoma 47:1932-1940(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Classical Hodgkin Lymphoma EMBL CAJ28923.1.
[2]	"Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells." Janz M., Stuhmer T., Vassilev L.T., Bargou R.C. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF101868 mRNA. Translation: ABL09847.1. AM076972 mRNA. Translation: CAJ28923.1.
IPI	IPI01011775.
UniGene	Hs.437460. Hs.740601.
3D structure databases
ProteinModelPortal	Q1MSW8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005201.
Family and domain databases
Gene3D	2.60.40.720. 1 hit.
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA-bd. IPR011615. p53_DNA-bd. IPR013872. p53_transactivation_domain. IPR002117. p53_tumour_suppressor. [Graphical view]
PANTHER	PTHR11447. PTHR11447. 1 hit.
Pfam	PF00870. P53. 1 hit. PF08563. P53_TAD. 1 hit. [Graphical view]
PRINTS	PR00386. P53SUPPRESSR.
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS00348. P53. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TP53. human.

Entry information

Entry name

Q1MSW8_HUMAN

Accession

Primary (citable) accession number: Q1MSW8

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.