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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Lawsonia intracellularis (strain PHE/MN1-00)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciLINT363253:GH6E-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:LI0005Imported
OrganismiLawsonia intracellularis (strain PHE/MN1-00)Imported
Taxonomic identifieri363253 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeLawsonia
ProteomesiUP000002430 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi363253.LI0005.

Structurei

3D structure databases

ProteinModelPortaliQ1MSG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263449.
KOiK04565.
OMAiGKCEPPF.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1MSG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKLFFVTS IVTISLLTSI TSVVLACSVT SEVHMIDDNG IKQSIGTVTF
60 70 80 90 100
TDTDKGLQIK TDLKGLPAGE HGFHIHEGGS CGPAEHDGHL TAGLQAHGHY
110 120 130 140 150
DPDKTGKHEG PLGNGHKGDL PRLVVKADGI AKETLLAPRL TVKEIKGRTV
160 170 180
MIHAGGDNYS DKPLPLGGGG ARIACGVIPN
Length:180
Mass (Da):18,827
Last modified:May 30, 2006 - v1
Checksum:iB2D8B665BAD0D665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54061.1.
RefSeqiWP_011526088.1. NC_008011.1.
YP_594383.1. NC_008011.1.

Genome annotation databases

KEGGilip:LI0005.
PATRICi22303299. VBILawInt40445_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180252 Genomic DNA. Translation: CAJ54061.1.
RefSeqiWP_011526088.1. NC_008011.1.
YP_594383.1. NC_008011.1.

3D structure databases

ProteinModelPortaliQ1MSG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi363253.LI0005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGilip:LI0005.
PATRICi22303299. VBILawInt40445_0005.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263449.
KOiK04565.
OMAiGKCEPPF.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciLINT363253:GH6E-5-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy."
    Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PHE/MN1-00Imported.

Entry informationi

Entry nameiQ1MSG4_LAWIP
AccessioniPrimary (citable) accession number: Q1MSG4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.