Q1MS81 (Q1MS81_LAWIP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DUTPase EMBL CAJ54144.1

Gene names

Name:	dut EMBL CAJ54144.1
Ordered Locus Names:	LI0088

Organism

Lawsonia intracellularis (strain PHE/MN1-00) [Complete proteome] [HAMAP]

Taxonomic identifier

363253 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Lawsonia

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181 Metal-binding SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1MS81 [UniParc]. Last modified May 30, 2006. Version 1. Checksum: 849F08B70E8445A1	FASTA	160	17,336
	10 20 30 40 50 60 MSAFLHSEVS IRFMYLRDAK KIYTTSGIAY ETPASVGLDL RACIEETSLT ILPGERETIP 70 80 90 100 110 120 CGIAIEPLEK NIAGFVYSRS GLGAIHGLTV AQGVGVIDPD YRGEIIVVLL NTAKNPVHVN 130 140 150 160 RGDRIAQLVF QPAFQVSLVE TQQLDNTSRG SFGFGHTGKN

References

[1]

"The complete genome sequence of Lawsonia intracellularis: the causative agent of proliferative enteropathy." Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L., Peterson A., May B., Singh S., Gebhart C., Kapur V. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PHE/MN1-00 EMBL CAJ54144.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180252 Genomic DNA. Translation: CAJ54144.1.
RefSeq	YP_594466.1. NC_008011.1.
3D structure databases
ProteinModelPortal	Q1MS81.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1MS81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4059298.
GenomeReviews	Gene locus LI0088 in contig AM180252_GR.
KEGG	lip:LI0088.
PATRIC	22303497. VBILawInt40445_0101.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0756.
HOGENOM	HBG436079.
OMA	LDLRACI.
PhylomeDB	Q1MS81.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1MS81_LAWIP

Accession

Primary (citable) accession number: Q1MS81

Entry history

Integrated into UniProtKB/TrEMBL:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)